Ferulic acid attenuates the cerebral ischemic injury-induced decrease in peroxiredoxin-2 and thioredoxin expression

Sung, Jin-Hee; Gim, Sang-Ah; Koh, Phil-Ok

doi:10.1016/j.neulet.2014.02.040

Cited by 50 publications

(26 citation statements)

References 23 publications

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“…In general, the HCA derivatives under study display a remarkable outline. 32,[77][78][79][80] These results indicate that simple structural modications on natural bioactive templates can lead to neuroprotective derivatives that retain the activity of the parent compounds. 3A and D).…”

Section: Neuroprotection Against 6-hydroxydopamine Induced Damagementioning

confidence: 99%

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

et al. 2015

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Section: Neuroprotection Against 6-hydroxydopamine Induced Damagementioning

confidence: 99%

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

et al. 2015

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“…For instance, Koh indicated that FA attenuated the downregulation of MEK/ERK/p90RSK signaling pathway in focal cerebral ischemic injury (Koh, ). Sung et al revealed the attenuation of decrease in peroxiredoxin‐2 and thioredoxin expression by FA in cerebral ischemic injury (Sung, Gim, & Koh, ). FA has also been shown to ameliorate renal injury against glycerol‐induced nephrotoxicity in Wistar rats via modulation of nuclear factor‐kappaB (Manikandan et al, ).…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid improves self‐renewal and differentiation of human tendon‐derived stem cells by upregulating early growth response 1 through hypoxia

Qiu

Sun

et al. 2019

Genesis

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We aimed to investigate the potential beneficial effect of ferulic acid (FA) on stemness of human tendon-derived stem cells (hTSCs) in vitro and to elucidate the underlying molecular mechanism.The self-renewal ability of hTSCs was evaluated by colony formation and cell proliferation was determined by CCK-8 kit. Adipogenesis, osteogenesis, and chondrogenesis were determined by Oil Red O, Alizarin Red, and Alcian Blue stainings, respectively. Relative mRNA levels of PPARγ, Col2A1, Acan, Runx2, HIF1α, and EGR1 were measured with real-time PCR. Protein levels of HIF1α and EGR1 were detected by western blot. Direct binding of HIF1α with EGR1 promoter was analyzed by ChIP assay. Hypoxia-induced expression of EGR1 was interrogated by luciferase reporter assay. We demonstrated that FA treatment improved both self-renewal ability and multi-differentiation potential of hTSCs. FA induced hypoxia which in turn upregulated EGR1 expression via direct association with its hypoxia response element consensus sequence.Furthermore, we showed that both HIF1α and EGR1 were required for the enhancing effects of FA on hTSC self-renewal and differentiation. We hereby characterize the beneficial effect of FA on the stemness of hTSCs and highlight the critical role of HIF1α-EGR1 axis in this process. K E Y W O R D SEGR1, ferulic acid, human tendon-derived stem cells, hypoxia, multi-differentiation

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“…As we accurately identified paeoniflorin (peak 7) and ferulic acid (peak 8) in the serum samples of DSS, and assay results indicated paeoniflorin and ferulic acid were the main components in DSS, it seemed that the two transitional blood components were the key active components of DSS. Ferulic acid acted as a quality marker of A. sinensis, and L. chuanxiong, recorded in Chinese Pharmacopoeia, has been reported to treat coronary heart disease and has neuroprotective, antioxidant, and anti-inflammatory properties (Ren et al, 2013;Picone et al, 2013;Sung et al, 2014). Although some studies investigated whether ferulic acid was present in the aerial part of A. macrocephala (Peng et al, 2011), there was no report in the rhizome of A. macrocephala.…”

Section: Determination the Transitional Blood Components Of Dssmentioning

confidence: 99%

The difference between blood‐associated and water‐associated herbs of Danggui‐Shaoyao San in theory of TCM, based on serum pharmacochemistry

Wang

Zhou

et al. 2015

Biomedical Chromatography

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Danggui-Shaoyao San (DSS) is a famous Chinese formula for activating blood circulation and promoting urination. This study was to investigate the difference of material basis between a blood-associated herbs group and a water-associated herbs group. According to the theory of traditional Chinese medicine, the formula can be divided into a blood-associated herbs group (Angelica sinensis, Paeonia lactiflora and Ligusticum chuanxiong) and a water-associated herbs group (Atractylodes macrocephala, Alisma orientale and Poria cocos). The HPLC fingerprint of the formula was established for quality control. Serum samples from rats, orally administrated DSS, and the decomposed recipes of DSS, were analyzed by HPLC-DAD and the transitional blood components of DSS were identified. Twenty-one common peaks were identified in the fingerprint of DSS. Contents of paeoniflorin, albiflorin, ferulic acid and alisol B 23-acetate in co-decoction were significantly higher than those in individual decoction. Eleven peaks belonged to the blood-associated herbs group (four metabolites and seven prototype components; paeoniflorin and ferulic acid appeared in prototype components), whereas six peaks belonged to the water-associated herbs group (three metabolites and three prototype components). It was concluded that the serum pharmacochemistry is a meaningful approach for clarifying the difference between blood-associated and water-associated herbs in chemical composition.

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Ferulic acid attenuates the cerebral ischemic injury-induced decrease in peroxiredoxin-2 and thioredoxin expression

Cited by 50 publications

References 23 publications

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity

Ferulic acid improves self‐renewal and differentiation of human tendon‐derived stem cells by upregulating early growth response 1 through hypoxia

The difference between blood‐associated and water‐associated herbs of Danggui‐Shaoyao San in theory of TCM, based on serum pharmacochemistry

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