FerucarbotranversusGd-DTPA-enhanced MR imaging in the detection of focal hepatic lesions

Application of magnetic iron oxide nanomaterials in tumor imaging

“…掺杂过渡金属还可改变MIONs的磁性, 使饱 和磁化值大大增加 [16] , 缩短横向弛豫时间, 具有更强的 ≈59 羧基化葡聚糖 前哨淋巴结探测 用于前哨淋巴结探测 势 [39,40] . 虽然有临床试验表明, Ferucarbotran增强的 MRI在探测微小局部肝脏病灶优于钆造影剂 [41] . 但考 虑到价格因素, 在市场中极少用户愿意使用磁性铁氧 化物纳米材料.…”

Focal Liver Lesions: Detection and Characterization at Double-Contrast Liver MR Imaging with Ferucarbotran and Gadobutrol versus Single-Contrast Liver MR Imaging

“…In intact liver parenchyma, SPIOs are trapped by the Kupffer cells, which are part of the reticuloendothelial system that lines the hepatic sinusoids. Because the accumulation of SPIOs causes local magnetic field inhomogeneity, there is considerable T2 and T2* shortening with reduced signal intensity of the liver on T2-and T2*-weighted MR images (3,(10)(11)(12)(13)(14)(15). The degree of signal intensity reduction in focal liver lesions with reduced numbers of Kupffer cells is lower than that in intact liver parenchyma.…”

MR and optical imaging of early micrometastases in lymph nodes: triple labeling with nano‐sized agents yielding distinct signals

“…Nanoparticles such as iron oxides and dendrimers are well suited to study of the lymphatics, not only because of the size-selectivity of the lymphatic system, but also because of the enhanced signals that derive from larger particles. For example, superparamagnetic iron oxide (SPIO) nano-particles can increase R 2 * more than >30-fold at 1.5 T and higher under greater magnetic field strength (7), and gadolinium-dendrimer-molecules can increase R 1 more than 10 000-fold compared with small gadolinium-chelates (8,9). Therefore, low concentrations of these particles or molecules can be detected with MRI.…”