Fertility and Risk Factors for Elevated Infertility Concern in 10-Year Hematopoietic Cell Transplant Survivors and Case-Matched Controls

Hammond, Camille; Abrams, Janet; Syrjala, Karen L.

doi:10.1200/jco.2007.10.8993

Cited by 83 publications

(64 citation statements)

References 21 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential for abnormal development, infertility, and sexual dysfunction is a source of significant emotional distress for survivors. [1][2][3] Recognizing treatment-associated risks and educating survivors and providers about potential reproductive complications is a key component of follow-up care. The Children's Oncology Group (COG) developed clinical practice guidelines to aid the assessment of survivors of childhood and adolescent cancers for long-term complications.…”

Section: Introductionmentioning

confidence: 99%

Male Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: A Report From the Children's Oncology Group

Kenney

Cohen

Shnorhavorian

et al. 2012

JCO

165

139

View full text Add to dashboard Cite

The majority of children, adolescents, and young adults diagnosed with cancer will become long-term survivors. Although cancer therapy is associated with many adverse effects, one of the primary concerns of young male cancer survivors is reproductive health. Future fertility is often the focus of concern; however, it must be recognized that all aspects of male health, including pubertal development, testosterone production, and sexual function, can be impaired by cancer therapy. Although pretreatment strategies to preserve reproductive health have been beneficial to some male patients, many survivors remain at risk for long-term reproductive complications. Understanding risk factors and monitoring the reproductive health of young male survivors are important aspects of follow-up care. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) were created by the COG to provide recommendations for follow-up care of survivors at risk for long-term complications. The male health task force of the COG-LTFU Guidelines, composed of pediatric oncologists, endocrinologists, nurse practitioners, a urologist, and a radiation oncologist, is responsible for updating the COG-LTFU Guidelines every 2 years based on literature review and expert consensus. This review summarizes current task force recommendations for the assessment and management of male reproductive complications after treatment for childhood, adolescent, and young adult cancers. Issues related to male health that are being investigated, but currently not included in the COG-LTFU Guidelines, are also discussed. Ongoing investigation will inform future COG-LTFU Guideline recommendations for follow-up care to improve health and quality of life for male survivors.

show abstract

Section: Introductionmentioning

confidence: 99%

Male Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: A Report From the Children's Oncology Group

Kenney

Cohen

Shnorhavorian

et al. 2012

JCO

165

139

View full text Add to dashboard Cite

show abstract

“…Several studies reported that the regimens used for allogeneic stem cell conditioning cause the most severe damage, especially in the case of total body irradiation (TBI), with POF and infertility almost constantly occurring in adults and in up to 81% of cases in children. 29,30 Pregnancies have been reported after conditioning with BEAM (carmustine, etoposide, cytarabine, melphalan) and autologous transplantation. A recent report from the Late Effects Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR) concluded that some patients who received TBI and/or myeloablative conditioning can preserve their fertility.…”

Section: Treatments Of Refractory Lymphoma or Relapses And Second-linmentioning

confidence: 99%

Management of fertility in patients treated for Hodgkin's lymphoma

Harel¹,

Fermé²,

Poirot³

2011

Haematologica

View full text Add to dashboard Cite

show abstract

“…53 Only a minority of AYA cancer survivors has reported satisfaction with the fertility information they received from their providers. 47,48,[63][64][65] Among those with low satisfaction with fertility information received, there is also a low expectation for quality of life outcomes around relationships and fertility. 19 Patients have identified a desire to be told accurate information about their prognosis and their risks and to play a contributing role in their treatment decisions.…”

Section: Practice Guidance For Fertility Preservationmentioning

confidence: 99%

A Review of the Oncology Patient's Challenges for Utilizing Fertility Preservation Services

Flink

Sheeder

Kondapalli

2017

Journal of Adolescent and Young Adult Oncology

View full text Add to dashboard Cite

Purpose: The American Society of Clinical Oncology issued practice guidelines in 2006 to provide critical information about fertility impact to adolescents and young adults (AYA) at the time of cancer diagnosis. Survivors continue to express concerns about their long-term reproductive health after cancer therapy even as treatment options for fertility preservation evolve. An underutilization of fertility preservation methods by cancer patients continues to persist. A review of the literature cites barriers and challenges that limit fertility information and preservation options for AYA cancer patients. Methods: A review of medical literature was conducted to examine current practice for patients receiving fertility information and the barriers to patients receiving fertility preservation services. Results: A total of 69 publications were included in this review. The review summarizes (1) patient experiences with receiving fertility information and (2) patient desires, barriers, and challenges to utilizing fertility preservation services. Conclusions: Despite advances in fertility preservation, there are challenges for patients to utilizing fertility preservation services. Barriers include the following: urgency to initiate treatment, inadequate information, clinic time constraints, and perceptions around patients' gender, age, cost, parity, race, relationship, and sociodemographic status influence whether patients receive fertility preservation consultation. Patients report a lack of adequate information to make informed fertility decisions.

show abstract

Fertility and Risk Factors for Elevated Infertility Concern in 10-Year Hematopoietic Cell Transplant Survivors and Case-Matched Controls

Abstract: The prevalence of infertility and related concerns is higher among long-term SCT survivors than among age-, sex-, and education-matched controls. Younger SCT recipients and those without children have persistent fertility-related needs even 10 years after treatment.

Cited by 83 publications

References 21 publications

Male Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: A Report From the Children's Oncology Group

Male Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: A Report From the Children's Oncology Group

Management of fertility in patients treated for Hodgkin's lymphoma

A Review of the Oncology Patient's Challenges for Utilizing Fertility Preservation Services

Contact Info

Product

Resources

About