Ferroptosis in liver cancer: a key role of post-translational modifications
Ying Xu,
Zhiyao Xing,
Ruaa Abdalla Ibrahim Suliman
et al.
Abstract:Ferroptosis is an emerging form of regulated cell death in an oxidative stress- and iron-dependent manner, primarily induced by the over-production of reactive oxygen species (ROS). Manipulation of ferroptosis has been considered a promising therapeutic approach to inhibit liver tumor growth. Nevertheless, the development of resistance to ferroptosis in liver cancer poses a significant challenge in cancer treatment. Post-translational modifications (PTMs) are crucial enzymatic catalytic reactions that covalent… Show more
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