Ferromagnetic Hyperthermia and Iodine 125 Brachytherapy in the Treatment of Choroidal Melanoma in a Rabbit Model

A 27 MHz current source interstitial hyperthermia system for small animals

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A 27 MHz current source interstitial hyperthermia system for small animals

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A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

“…With the plaque used, the slope of intraocular temperature decline was 0.2°C/ mm. This decline is much less pronounced than with current microwave or ferromagnet ic plaques (-1°C) [3,12,23]; it is even some what less pronounced than with LCF plaques (0.3°C) [20]. The decrease in intraocular tem perature in tumor-containing eyes has been demonstrated to be even less rapid than in tumor-free eyes [24], According to Finger et al [3,12], plaque temperatures up to 47 °C may be tolerated .With the warm-water perfu- sion plaque and an inflow temperature of 45°C, therapeutic temperature levels may thus be reached at a depth exceeding 10 mm.…”

Breakdown of the Blood-Retinal Barrier after Radiofrequency-Induced Ocular Hyperthermia

“…Riedel et al [5] reported local retinal edema after ultrasonically in duced hyperthermia at 43°C in rabbits. Addi tionally, Mieler et al [6] observed subretinal fluid accumulation after ferromagnetic hyper thermia at approximately 43.6°C. Specific nonthcrmal effects may lead to the discrepan cy in the critical temperature to cause retinal edema among several different modes of heat treatment.…”

“…Hyperthermia is used in the treatment of ocular tumors [3][4][5][6], Our method of radiofre quency (RF) hyperthermia is capable of pro ducing a better temperature distribution for the treatment of posterior segment disease than other heating systems. Recently, we reported the suppressive effect of heat treat ment at approximately 42.4°C on the devel opment of PVR in a rabbit model [7].…”

A 27 MHz current source interstitial hyperthermia system for small animals

“……”

A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

“…With the plaque used, the slope of intraocular temperature decline was 0.2°C/ mm. This decline is much less pronounced than with current microwave or ferromagnet ic plaques (-1°C) [3,12,23]; it is even some what less pronounced than with LCF plaques (0.3°C) [20]. The decrease in intraocular tem perature in tumor-containing eyes has been demonstrated to be even less rapid than in tumor-free eyes [24], According to Finger et al [3,12], plaque temperatures up to 47 °C may be tolerated .With the warm-water perfu- sion plaque and an inflow temperature of 45°C, therapeutic temperature levels may thus be reached at a depth exceeding 10 mm.…”

Breakdown of the Blood-Retinal Barrier after Radiofrequency-Induced Ocular Hyperthermia

“…Riedel et al [5] reported local retinal edema after ultrasonically in duced hyperthermia at 43°C in rabbits. Addi tionally, Mieler et al [6] observed subretinal fluid accumulation after ferromagnetic hyper thermia at approximately 43.6°C. Specific nonthcrmal effects may lead to the discrepan cy in the critical temperature to cause retinal edema among several different modes of heat treatment.…”

“…Hyperthermia is used in the treatment of ocular tumors [3][4][5][6], Our method of radiofre quency (RF) hyperthermia is capable of pro ducing a better temperature distribution for the treatment of posterior segment disease than other heating systems. Recently, we reported the suppressive effect of heat treat ment at approximately 42.4°C on the devel opment of PVR in a rabbit model [7].…”

A 27 MHz current source interstitial hyperthermia system for small animals

“……”

A Warm-Water Perfusion Plaque for Hyperthermic Treatment of Intraocular Tumors

“…With the plaque used, the slope of intraocular temperature decline was 0.2°C/ mm. This decline is much less pronounced than with current microwave or ferromagnet ic plaques (-1°C) [3,12,23]; it is even some what less pronounced than with LCF plaques (0.3°C) [20]. The decrease in intraocular tem perature in tumor-containing eyes has been demonstrated to be even less rapid than in tumor-free eyes [24], According to Finger et al [3,12], plaque temperatures up to 47 °C may be tolerated .With the warm-water perfu- sion plaque and an inflow temperature of 45°C, therapeutic temperature levels may thus be reached at a depth exceeding 10 mm.…”

Breakdown of the Blood-Retinal Barrier after Radiofrequency-Induced Ocular Hyperthermia

“…Riedel et al [5] reported local retinal edema after ultrasonically in duced hyperthermia at 43°C in rabbits. Addi tionally, Mieler et al [6] observed subretinal fluid accumulation after ferromagnetic hyper thermia at approximately 43.6°C. Specific nonthcrmal effects may lead to the discrepan cy in the critical temperature to cause retinal edema among several different modes of heat treatment.…”

“…Hyperthermia is used in the treatment of ocular tumors [3][4][5][6], Our method of radiofre quency (RF) hyperthermia is capable of pro ducing a better temperature distribution for the treatment of posterior segment disease than other heating systems. Recently, we reported the suppressive effect of heat treat ment at approximately 42.4°C on the devel opment of PVR in a rabbit model [7].…”