Ferrite particles: a superparamagnetic MR contrast agent for enhanced detection of liver carcinoma.

Saini, Sanjay; Stark, D D; Hahn, Peter F.; Bousquet, Jean; Introcasso, J; Wittenberg, J; Brady, T J; Ferrucci, J T

doi:10.1148/radiology.162.1.3786766

Cited by 117 publications

(52 citation statements)

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“…SPIO are ingested by macrophages of the RES, resulting in signal loss in normal tissue [8, 9]. SPIO-MRI is an imaging modality that is different from CTAP/CTHA and iv-CT which demonstrate alterations is blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…SPIO are ingested by macrophages of the reticuloendothelial system (RES), resulting in signal loss in normal tissue. Metastases and some malignant liver tumors, having no RES, retain their signal intensity and can be distinguished from the normal liver [8, 9]. It has been reported that SPIO-MRI is an efficacious modality for the diagnosis of focal liver lesions [10, 11, 12].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of SPIO-MR Imaging in the Diagnosis of Liver Metastases from Colorectal Carcinomas

Furuhata

Okita²,

Tsuruma³

et al. 2003

Dig Surg

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Aim: To determine whether superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) could replace intravenous contrast-enhanced spiral CT (iv-CT) and spiral CT during arterial portography (CTAP) combined with spiral CT hepatic angiography (CTHA) in the diagnosis of liver metastases from colorectal carcinomas. Methods: Twenty-six adult patients with liver metastases were studied preoperatively by means of iv-CT, CTAP/CTHA, and SPIO-MRI. Preoperative diagnoses using iv-CT, CTAP/CTHA, and SPIO-MRI were compared with intraoperative and pathological findings in resected specimens. The gold standard for the lesions that were resected was histological examination. Intraoperative findings represented the gold standard for lesions that were not resected. Results: Twenty-six patients were found to have a total number of 43 liver metastases. The sensitivities of iv-CT, CTAP/CTHA, and SPIO-MRI were 74.4, 100, and 90.7%, respectively. SPIO-MRI was significantly superior to iv-CT (p < 0.05). The positive predictive values of iv-CT, CTAP/CTHA, and SPIO-MRI were 97.0, 91.5, and 100%, respectively. CTAP/CTHA yielded four false-positive lesions. In contrast, we detected no false-positive findings using SPIO-MRI. Conclusions: These results suggest that SPIO-MRI might not completely replace CTAP/CTHA, but could replace iv-CT in the diagnosis of liver metastases from colorectal carcinomas. It is thought that SPIO-MRI is a promising imaging modality for diagnosing liver metastases in patients with colorectal carcinoma because of its relatively high sensitivity and extremely high specificity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of SPIO-MR Imaging in the Diagnosis of Liver Metastases from Colorectal Carcinomas

Furuhata

Okita²,

Tsuruma³

et al. 2003

Dig Surg

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“…It can be injected intravenously as a bolus for imaging HCC [40]. SPIO acts as a negative contrast agent because SPIO particles are taken up by Kupffer cells in the reticuloendothelial system of the liver [41,42], causing a local magnetic field inhomogeneity and resulting in considerable T2* shortening [42]. SPIO-enhanced MR is reported to be sensitive in detecting HCC [43,44,45].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

et al. 2011

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Detection, characterization, staging, and treatment monitoring are major roles in imaging diagnosis in liver cancers. Contrast-enhanced ultrasonography (CEUS) using microbubble contrast agents has expanded the role of US in the detection and diagnosis of liver nodules in patients at high risk of hepatocellular carcinoma (HCC). CEUS provides an accurate differentiation between benign and malignant liver nodules, which is critical for adequate management of HCC and is also useful for guidance of percutaneous local therapy of HCC and postprocedure monitoring of the therapeutic response. The technology of multidetector-row computed tomography (MDCT) has increased spatial and temporal resolutions of computed tomography (CT). It has made possible a more precise evaluation of the hemodynamics of liver tumor, and the diagnostic accuracy of dynamic MDCT has improved. Perfusion CT can measure tissue perfusion parameters quantitatively and can assess segmental hepatic function. Dynamic MDCT with high spatial and temporal resolution enables us to reconstruct 3- and 4-dimensional imaging, which is very useful for pretreatment evaluation. Dual-energy CT makes possible the differentiation of materials and tissues in images obtained based on the differences in iodine and water densities. Monochromatic images, which can be reconstructed by dual-energy CT data, provide some improvement in contrast and show a higher contrast-to-noise ratio for hypervascular HCCs. Dynamic magnetic resonance imaging with fast imaging sequence of 3-dimensional Fourier transformation T₁-weighted gradient echo and nonspecific contrast medium can show high detection sensitivity of hypervascular HCC. However, the hepatic tissue-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid, has become an essential contrast medium for liver imaging because of its higher diagnostic ability. It may replace CT during hepatic arteriography and during arterioportography.

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“…Superparamagnetic iron oxide (SPIO), which is taken up by Kupffer cells in the liver and by macrophages in the spleen, is a tissue-specific MRI agent [5, 6]. Mergo and Ros [7] demonstrated that well-differentiated hepatocellular carcinomas (HCCs) took up a greater amount of SPIO than less differentiated HCCs, possibly because of the greater proportion of Kupffer cells in well-differentiated HCCs.…”

Section: Introductionmentioning

confidence: 99%

Imaging of Hepatocellular Carcinoma: Qualitative and Quantitative Analysis of Postvascular Phase Contrast-Enhanced Ultrasonography with Sonazoid

Inoue¹,

Kudo²,

Hatanaka³

et al. 2008

Oncology

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Purpose: To evaluate the usefulness of vascular phase images of contrast-enhanced ultrasonography (CE-US) with Sonazoid for hepatocellular carcinomas (HCCs), a retrospective, comparative study was conducted of images of HCCs obtained by CE-US and superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) and evaluated qualitatively and quantitatively. Methods: Seventy-seven patients with 88 HCCs who received CE-US and SPIO-MRI were reviewed. The ratio of the echogenicity of the tumor and nontumor areas was calculated with postvascular phase CE-US (postvascular phase ratio). The ratio of the intensity of the nontumor to tumor areas on SPIO-enhanced MRI (SPIO intensity index) was also calculated. The Pearson correlations were calculated for all values between the postvascular phase ratio and SPIO intensity index for quantitative comparison. These images were also compared qualitatively for the detection rate of the tumors. Results: The sensitivities of CE-US and SPIO-MRI in detecting tumors were 98 and 95%, respectively (nonsignificant, χ² test). The postvascular phase ratio correlated with the SPIO intensity index for HCCs (Pearson r = 0.803, p < 0.05). The image conformity of the result from the liver parenchymal phase CE-US and SPIO-MRI was 92%. Dedifferentiation spots of nodule-in-nodule HCCs were detected in 4 (80%) of 5 on postvascular phase images of CE-US, and in 2 (40%) of 5 on SPIO-MRI (nonsignificant, χ² test). Conclusions: Postvascular phase images of CE-US with Sonazoid appear promising as an alternative to SPIO-enhanced MRI. Further study cases are needed to confirm the usefulness of postvascular phase images of CE-US compared to SPIO-MRI for the detection of dedifferentiation foci in hepatic tumors.

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Ferrite particles: a superparamagnetic MR contrast agent for enhanced detection of liver carcinoma.

Cited by 117 publications

References 0 publications

Efficacy of SPIO-MR Imaging in the Diagnosis of Liver Metastases from Colorectal Carcinomas

Efficacy of SPIO-MR Imaging in the Diagnosis of Liver Metastases from Colorectal Carcinomas

Ultrasonography, Computed Tomography and Magnetic Resonance Imaging of Hepatocellular Carcinoma: Toward Improved Treatment Decisions

Imaging of Hepatocellular Carcinoma: Qualitative and Quantitative Analysis of Postvascular Phase Contrast-Enhanced Ultrasonography with Sonazoid

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