Fermented <i>Moringa oleifera</i> Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice

Joung, Hyunchae; Kim, Bobae; Park, Hyunjoon; Lee, Kyuyeon; Kim, Hee-Hoon; Sim, Ho-Cheol; Do, Hyun-Jin; Hyun, Chang‐Kee; Do, Myoung‐Sool

doi:10.1089/jmf.2016.3860

Cited by 48 publications

(38 citation statements)

References 40 publications

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“…To determine the effect of melatonin on HF diet‐fed mice, body weight, liver, and subcutaneous adipose tissue were weighed (Figure A‐D). As expected, HF diet significantly increased the body weight ( P < 0.05) and relative weight of subcutaneous adipose tissue to body weight in mice ( P < 0.001) . Melatonin treatment tended to alleviate HF‐induced weight gain, but the difference was insignificant ( P > 0.05).…”

Section: Resultssupporting

confidence: 53%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

319

277

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Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

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Section: Resultssupporting

confidence: 53%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

319

277

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“…In addition, quercetin may have been involved in the reduction of the inflammatory process by inhibiting the action of neutral factor kappa-beta (NF-kβ) and subsequent NF-kB-dependent downstream events and inflammation [ 80 ]. Further, fermentation of MO appears to enhance the anti-inflammatory properties of MO [ 81 ]. C57BL/6 mice, fed for 10 weeks with distilled water, fermented and non-fermented MO [ 81 ].…”

Section: Effects Of Moringa Oleifera On the Prementioning

confidence: 99%

“…Further, fermentation of MO appears to enhance the anti-inflammatory properties of MO [ 81 ]. C57BL/6 mice, fed for 10 weeks with distilled water, fermented and non-fermented MO [ 81 ]. Investigators reported decreases in the mRNA levels of inflammatory cytokines and reductions in endoplasmic reticulum stress in those animals fed the fermented product.…”

Section: Effects Of Moringa Oleifera On the Prementioning

confidence: 99%

Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease

2017

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Moringa Oleifera (MO), a plant from the family Moringacea is a major crop in Asia and Africa. MO has been studied for its health properties, attributed to the numerous bioactive components, including vitamins, phenolic acids, flavonoids, isothiocyanates, tannins and saponins, which are present in significant amounts in various components of the plant. Moringa Oleifera leaves are the most widely studied and they have shown to be beneficial in several chronic conditions, including hypercholesterolemia, high blood pressure, diabetes, insulin resistance, non-alcoholic liver disease, cancer and overall inflammation. In this review, we present information on the beneficial results that have been reported on the prevention and alleviation of these chronic conditions in various animal models and in cell studies. The existing limited information on human studies and Moringa Oleifera leaves is also presented. Overall, it has been well documented that Moringa Oleifera leaves are a good strategic for various conditions associated with heart disease, diabetes, cancer and fatty liver.

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“…MO roots showed evidence of restraint against IL‐2 activity (Sashidara et al, ). Fermentation of MO decreased hepatic adiposity, endoplasmic reticulum anxiety and improved resistance to glucose in obese mice (Joung et al, ).…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

169

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice

Cited by 48 publications

References 40 publications

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

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