Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

Seo, Dae Bang; Jeong, Hyun Woo; Cho, Dong−Hyun; Lee, Bum Jin; Lee, Ji Hae; Choi, Jae Young; Bae, Il-Hong; Lee, Sung Joon

doi:10.1089/jmf.2014.3265

Cited by 106 publications

(74 citation statements)

References 45 publications

(57 reference statements)

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“…However, after 8 wk, body weight gain was reduced in HFD mice administered with 0.2% and 0.8% TP. Consistent with a previous report, fermented green tea extract reduced body weight gain without a decrease in food intake (Seo et al., ). Moreover, 3 doses of TP equally decreased blood glucose levels elevated by the HFD and improved glucose tolerance in HFA mice.…”

Section: Discussionsupporting

confidence: 92%

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High‐Fat Diet Treated HFA Mice

Wang

Zeng

Liu

et al. 2018

Journal of Food Science

106

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Section: Discussionsupporting

confidence: 92%

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High‐Fat Diet Treated HFA Mice

Wang

Zeng

Liu

et al. 2018

Journal of Food Science

106

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“…transresveratrol [103]) have been used extensively. Often, such studies demonstrate that the test substance or (poly)phenol-rich commodity modulate the composition of the gut microbiota and / or ameliorate the harmful effects of the test animal's less than ideal diet [101][102][103][104][105][106][107][108].…”

Section: Prebiotic Effectsmentioning

confidence: 99%

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

267

172

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Please cite this article as: G. Williamson, M.N. Clifford, Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols, Biochemical Pharmacology (2017), doi: http://dx.doi.org/10.1016/ j. bcp.2017.03.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1Role of the small intestine, colon and microbiota in determining the metabolic fate of in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged.Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites. and are also present at high levels in supplements [4], and form essential components of many Chinese medicines [5]. A study within the European Prospective Investigation intoCancer and Nutrition (EPIC) using the Phenol Explorer database reported that the cohort studied consumed 427 different polyphenols including 94 that were consumed at a rate of >1 g/day. The estimated total polyphenol consumption ranged from 584 mg/day by Greek women to 1786 mg/day for men in Aarhus-Denmark. The corresponding data for Greek men and for Aarhus women were 744 mg/day and 1626 mg/ day, respectively, with all data adjusted for age and weighted by season and weekday of dietary recall [6]. This study defined the major contributors to be the phenolic acids (predominantly the caffeoylquinic acids (27-53%), also called chlorogenic acids) and flavonoids (predominantly flavanols (16-29%), proanthocyanidins (5-9%) and theaflavins (14-25%)) [6]. Hydroxybenzoic acids (3.3-7.4%), alkyl-phenols (1.6...

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“…Although this was associated with reduced serum insulin and insulin resistance, these effects were also reported for resveratrol which scarcely modified the profile of gut bacteria 47 . Similarly, fermented green tea extract was reported to alter the composition of gut microbiota and this was linked to a decrease in fat mass, reduced inflammation and alleviation of glucose intolerance 48 . Further, a polyphenol-rich cranberry extract was reported to protect mice from diet-induced obesity and metabolic perturbations, which was associated with a proportional increase in Akkermansia spp.…”

Section: Targeting High-fat-diet-induced Dysbiosis For Obesity Prevenmentioning

confidence: 99%

Influence of high-fat diet on gut microbiota

Murphy

Velázquez

Herbert

2015

Current Opinion in Clinical Nutrition and Metabolic Care

410

174

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Purpose of review This review will examine the recent scientific literature surrounding high-fat-diet (HFD)-induced alterations in gut microbiota and subsequent development of obesity and chronic disease risk. Recent findings Excessive consumption of HFDs has undoubtedly contributed to the obesity epidemic. However, the mechanisms responsible for this relationship are likely to be more complex than the simple concept of energy balance. In fact, emerging literature has implicated HFD-induced alterations in gut microbiota in the obesity epidemic. HFD consumption generally leads to a decrease in Bacteroidetes and an increase in Firmicutes, alterations that have been associated with obesity and subsequent development of chronic diseases. Potential mechanisms for this effect include 1) an improved capacity for energy harvest and storage and, 2) enhanced gut permeability and inflammation. We highlight the most important recent advances linking HFD-induced dysbiosis to obesity, explore the possible mechanisms for this effect, examine the implications for disease development, and evaluate the possibility of therapeutic targeting of the gut microbiome to reduce obesity. Summary A better understanding of the mechanisms linking HFD to alterations in gut microbiota is necessary to allow for the regulation of dysbiosis and ensuing promotion of anti-obesity effects.

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Fermented Green Tea Extract Alleviates Obesity and Related Complications and Alters Gut Microbiota Composition in Diet-Induced Obese Mice

Cited by 106 publications

References 45 publications

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High‐Fat Diet Treated HFA Mice

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High‐Fat Diet Treated HFA Mice

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Influence of high-fat diet on gut microbiota

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