Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles

Fei, Juan; Qu, Junle; Ding, Xinliang; Xue, Kai; Lu, Chuncheng; Chen, Jianfeng; Lee, Song; Xia, Yankai; Wang, Shoulin; Wang, Xinru

doi:10.1016/j.tox.2009.10.022

Cited by 47 publications

(21 citation statements)

References 39 publications

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“…17 Fenvalerate, in similar studies, inhibited follicular growth and also decreased production of steroid hormones, including progesterone. 25 Additional experimental studies, with lower doses, of the ovotoxicity of deltamethrin and cypermethrin, with mechanistic data, would inform assessment of the biologic plausibility of the association found in the present study.…”

Section: Discussionmentioning

confidence: 87%

Anti-Müllerian Hormone and Lifestyle, Reproductive, and Environmental Factors Among Women in Rural South Africa

Whitworth

Baird²,

Steiner

et al. 2015

Epidemiology

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Background Few data exist regarding antiMüllerian hormone, a marker of ovarian reserve, in relation to environmental factors with potential ovarian toxicity. Methods This analysis included 420 women from Limpopo, South Africa studied in 2010–2011. Women were administered comprehensive questionnaires, and plasma concentrations of antiMüllerian hormone and DDT were determined. We used separate multivariable models to examine the associations between natural log-transformed antiMüllerian hormone concentration (ng/ml) and each of the lifestyle, reproductive, and environmental factors of interest, adjusted for age, body mass index, education, and parity. Results The median age of women was 24 years (interquartile range [IQR]=22 to 26); the median antiMüllerian hormone concentration was 3.1 ng/ml (IQR=2.0 to 6.0). Women who reported indoor residual spraying in homes with painted walls (indicative of exposure to pyrethroids) had 25% lower (95% confidence interval [CI]=−39% to −8%) antiMüllerian hormone concentrations compared with women who reported no spraying. Little evidence of decreased antiMüllerian hormone concentrations was observed among women with the highest DDT levels. Compared with women who used an electric stove, no association was observed among women who cooked indoors over open wood fires. The findings also suggested lower antiMüllerian hormone concentrations among women who drank coffee (−19% [95% CI=−31% to −5%]) or alcohol (−21% [95% CI=−36% to −3%]). Conclusions These are among the first data regarding antiMüllerian hormone concentrations relative to pesticides and indoor air pollution. Our results are suggestive of decreased ovarian reserve associated with exposure to pyrethroid pesticides, which is consistent with laboratory animal data.

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Section: Discussionmentioning

confidence: 87%

Anti-Müllerian Hormone and Lifestyle, Reproductive, and Environmental Factors Among Women in Rural South Africa

Whitworth

Baird²,

Steiner

et al. 2015

Epidemiology

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“…2012 ). Animal studies have revealed that PYR exposures can inhibit steroid hormones, restrain the growth of follicles, and damage ovarian corpus luteum cells, which might further contribute to decreased fertility ( Fei et al. 2010 ; Guerra et al.…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies have found adverse effects of OP and PYR exposures on female reproductive functions, including inhibited steroid hormones, disordered estrous cycles, and restrained follicle cells, which might ultimately lead to decreased fertility ( Fei et al. 2010 ; Geng et al.…”

Section: Introductionmentioning

confidence: 99%

Organophosphate and Pyrethroid Pesticide Exposures Measured before Conception and Associations with Time to Pregnancy in Chinese Couples Enrolled in the Shanghai Birth Cohort

Zhang

et al. 2018

Environ Health Perspect

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Background:Pesticides have been associated with reproductive disorders, but there is limited research on pesticide exposures and human fertility.Objective:We aimed to investigate the effects of preconception exposure to pesticides on time to pregnancy (TTP) and on infertility in a general population of couples planning to become pregnant in Shanghai, China.Methods:A total of 615 women who were planning a pregnancy were enrolled before conception and were prospectively followed for 1 y to observe their TTP. Preconception pesticide exposures were assessed by measuring urinary metabolites of organophosphates (OPs) and pyrethroids (PYRs). Fecundability odds ratios (FORs) and odds ratios (ORs) of infertility were estimated using Cox and logistic regression models, respectively. All analyses were repeated after restricting the sample to nulliparous women (n=569).Results:After adjusting for age, prepregnancy BMI, current smoking, education, annual household income, age at menarche, and two items from the Perceived Stress Scale (PSS-10), women in the highest quartile of diethylthiophosphate (DETP; an OP metabolite) had significantly longer TTP [adjusted FOR=0.68 (95% CI: 0.51, 0.92)] and increased infertility [adjusted OR=2.17 (95% CI: 1.19, 3.93)] compared with women in the lowest quartile. The highest versus lowest quartile of 3-phenoxybenzoic acid (3PBA; a PYR metabolite) was associated with longer TTP and infertility, with significant associations in nulliparous women [adjusted FOR=0.72 (95% CI: 0.53, 0.98); adjusted OR for infertility=2.03 (95% CI: 1.10, 3.74)].Conclusion:Our study provides some of the first evidence that preconception OP and PYR exposures are associated with decreased fertility in Chinese couples. Given that OPs and PYRs are rapidly metabolized in humans, more studies are needed to confirm our findings. https://doi.org/10.1289/EHP2987

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“…Studies have indicated that Fen treatment can change the level of mRNA and protein of StAR, P450scc, and P450 (17 a) in primary culture of ovarian follicles, 29 granulose cells, 30 testes, 3,21 and even in the brain. 31 The altering in testicular StAR and P450scc activity levels along with a change in steroid hormone level also has been reported following exposure to other xenobiotics.…”

Section: Discussionmentioning

confidence: 99%

Paternal Fenvalerate Exposure Influences Reproductive Functions in the Offspring

et al. 2013

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Fenvalerate (Fen), a synthetic pyrethroid insecticide, has been shown to have adverse effects on male reproductive system. Thus, the aim of the present study was to elucidate whether these adverse effects are passed from exposed male mice to their offspring. Adult male mice received Fen (10 mg/kg) daily for 30 days and mated with untreated females to produce offspring. Fenvalerate significantly changed the methylation status of angiotensin I-converting enzyme (Ace), forkhead box O3 (Foxo3a), huntingtin-associated protein 1 (Hap1), nuclear receptor subfamily 3 (Nr3c2), promyelocytic leukemia (Pml), and Prostaglandin F2 receptor negative regulator (Ptgfrn) genes in paternal mice sperm genomic DNA. Further, Fen significantly increased sperm abnormalities; serum testosterone and estradiol-17ß level in adult male (F0) and their male offspring (F1). Further, paternal Fen treatment significantly increased the length of estrous cycle, serum estradiol-17ß concentration in estrus, and progesterone levels in diestrus in female offspring (F1). These findings suggest that adverse effects of paternal Fen exposure on reproductive functions can be seen not only in treated males (F0) but also in their offsprings.

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Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles

Cited by 47 publications

References 39 publications

Anti-Müllerian Hormone and Lifestyle, Reproductive, and Environmental Factors Among Women in Rural South Africa

Anti-Müllerian Hormone and Lifestyle, Reproductive, and Environmental Factors Among Women in Rural South Africa

Organophosphate and Pyrethroid Pesticide Exposures Measured before Conception and Associations with Time to Pregnancy in Chinese Couples Enrolled in the Shanghai Birth Cohort

Paternal Fenvalerate Exposure Influences Reproductive Functions in the Offspring

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