Fentanyl, a μ-opioid receptor agonist, phase shifts the hamster circadian pacemaker

Meijer, Johanna H.; Ruijs, Aleid; Albus, Henk; Geest, Ben van de; Duindam, H.; Zwinderman, Aeilko H.; Dahan, Albert

doi:10.1016/s0006-8993(00)02317-9

Cited by 29 publications

(30 citation statements)

References 38 publications

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“…As reported previously, midazolam and fentanyl induced phase advances of the activity onset when injected during the mid-to late subjective day (Wee and Turek, 1989;Meijer et al, 2000). Despite considerable phase advances in the activity onset, the offset of activity did not phase advance.…”

Section: Discussionsupporting

confidence: 80%

“…Individual animals did not contribute more than 3 data points to 1 PRC and did not contribute more than 6 data points to the whole dataset. Part of the fentanylinduced phase shifts has been published previously (Meijer et al, 2000).…”

Section: Experimental Protocolmentioning

confidence: 99%

“…Endogenous enkephalins, as well as opioid receptors of the δ subtype, have been found in the hamster IGL and SCN (Morin et al, 1992;Byku et al, 2000). Several opioids have been shown to induce phase shifts in hamster circadian activity rhythms (Byku and Gannon, 2000a;Byku and Gannon, 2000b;Meijer et al, 2000;Tierno et al, 2002).…”

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confidence: 99%

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Differential Responses of Circadian Activity Onset and Offset Following GABA-ergic and Opioid Receptor Activation

et al. 2003

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The circadian pacemaker in the mammalian suprachiasmatic nuclei is responsive to photic and nonphotic stimuli. In the present study, the authors have investigated the response of activity onset and offset to application of nonphotic stimuli: the benzodiazepine midazolam and the opioid receptor agonist fentanyl. In correspondence with previous studies, both stimuli induced phase advances of the activity onset when given in the mid- to late subjective day. In contrast, activity offset did not phase advance following these injections. Injections during the early subjective day induced small phase delays of the activity onset, while large phase delays occurred in activity offset. Phase shifts, induced at both circadian time zones, were paralleled by an increase in the length of daily activity (alpha). The increase in a remained present during several days after the injection. The different kinetics in phase shifting of the activity onset and offset indicate complexity in phase-shifting behavior of the circadian pacemaker in response to nonphotic stimuli. Moreover, the data show responsiveness of the circadian system to GABA-ergic and opioid receptor activation, not only during the mid- to late subjective day but also during the early subjective day. The data implicate that the early subjective day is an interesting phase for analysis of molecular and biochemical processes involved in nonphotic phase shifting.

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Section: Discussionsupporting

confidence: 80%

Section: Experimental Protocolmentioning

confidence: 99%

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Differential Responses of Circadian Activity Onset and Offset Following GABA-ergic and Opioid Receptor Activation

et al. 2003

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“…Certain drugs of use in clinical practice, e.g. antidepressives as imipramine and lithium [81], opioid-agonists as fentanyl [82,83], benzodiazepines as triazolam [84], 2 adrenoceptor agonists as fenoterol o procaterol [52], sleep-inducer melatonin [85] and experimental drugs as tetrodoxin [86] and Nmethyl-D-aspartate (NMDA) [84] can modify the clock phase.…”

Section: The Circadian System: How Physiology and Behaviour Are Harmomentioning

confidence: 99%

Chronopharmacology and Antimicrobial Therapeutics

Rebuelto

2006

CCP

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Chronobiology studies the phenomenon of rhythmicity in living organisms. Circadian rhythms are genetically determined and are regulated by external synchronizers (i.e. light/day cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subject to circadian variations. Chronopharmacology studies how biological rhythms impact on drug pharmacokinetic (chronokinetics), pharmacodynamics (chronoesthesy) and toxicity and determines whether time of day administration modifies drug's pharmacological characteristics. Chronotherapy applies chronopharmacological studies to clinical treatments, determining the best biological time for its dosing, i.e. when beneficial effects are maximal and incidence and/or intensity of related side-effects and toxicity are minimal. Significant variations in the pharmacokinetics and toxicity of antibiotics (aminoglycosides, beta-lactams and fluoroquinolones) related to administration time are well known. The aims of this review are to discuss, briefly, the currently accepted model of the circadian system that substantiates endogenous rhythmicity and to provide an update on the knowledge of circadian rhythms applied to drugs used as medicines, with a special mention to the possible impact on antimicrobial treatments. It is concluded that the dosing time of an antimicrobial agent might be clinically relevant in some treatments, thus, clinicians should be aware that the dosing time might affect the clinical response of a drug.

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“…Opioids induce phase advance of the circadian system when applied during the day or interfere with photic entrainment when administered at night (Marchant and Mistlberger, 1995;Byku and Gannon, 2000a,b;Meijer et al, 2000;Vansteensel et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Acute morphine affects the rat circadian clock via rhythms of phosphorylated ERK1/2 and GSK3β kinases and Per1 expression in the rat suprachiasmatic nucleus

Pačesová

Volfová

Červená

et al. 2015

British J Pharmacology

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BACKGROUND AND PURPOSEOpioids affect the circadian clock and may change the timing of many physiological processes. This study was undertaken to investigate the daily changes in sensitivity of the circadian pacemaker to an analgesic dose of morphine, and to uncover a possible interplay between circadian and opioid signalling. EXPERIMENTAL APPROACHA time-dependent effect of morphine (1 mg·kg −1 , i.p.) applied either during the day or during the early night was followed, and the levels of phosphorylated ERK1/2, GSK3β, c-Fos and Per genes were assessed by immunohistochemistry and in situ hybridization. The effect of morphine pretreatment on light-induced pERK and c-Fos was examined, and day/night difference in activity of opioid receptors was evaluated by [ KEY RESULTSMorphine stimulated a rise in pERK1/2 and pGSK3β levels in the suprachiasmatic nucleus (SCN) when applied during the day but significantly reduced both kinases when applied during the night. Morphine at night transiently induced Period1 but not Period2 in the SCN and did not attenuate the light-induced level of pERK1/2 and c-Fos in the SCN. The activity of all three principal opioid receptors was high during the day but decreased significantly at night, except for the δ receptor. Finally, we demonstrated daily profiles of pERK1/2 and pGSK3β levels in the rat ventrolateral and dorsomedial SCN. CONCLUSIONS AND IMPLICATIONSOur data suggest that the phase-shifting effect of opioids may be mediated via post-translational modification of clock proteins by means of activated ERK1/2 and GSK3β. Abbreviations

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Fentanyl, a μ-opioid receptor agonist, phase shifts the hamster circadian pacemaker

Cited by 29 publications

References 38 publications

Differential Responses of Circadian Activity Onset and Offset Following GABA-ergic and Opioid Receptor Activation

Differential Responses of Circadian Activity Onset and Offset Following GABA-ergic and Opioid Receptor Activation

Chronopharmacology and Antimicrobial Therapeutics

Acute morphine affects the rat circadian clock via rhythms of phosphorylated ERK1/2 and GSK3β kinases and Per1 expression in the rat suprachiasmatic nucleus

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