Fenprostalene-induced Abortion in Bitches.

Abstract

ABSTRACT. A long-acting prostaglandin F 2α analogue, fenprostalene, was subcutaneously administered singly at doses of 5, 10, 25, 50, 100 or 150 µg on day 25 after ovulation during pregnancy in bitches (n=4 for each dosage), and maintenance of pregnancy, changes in plasma progesterone concentration, interval between the treatment and subsequent estrus and conception rate at that estrus were studied. Abortion was associated with a decrease in the plasma progesterone concentration below about 2 ng/ml, and the abortifacient effect was dose-dependent. Administration of 50 µg or more of fenprostalene induced abortion in all dogs 3 to 13 days after the treatment. The interval between administration and subsequent estrus was markedly shorter in the aborted bitches than in the non-aborted ones ( P<0.01). The conception rate at the estrus in the aborted dogs was 50%, whereas all of the bitches who had not aborted became pregnant. The results indicate that a single administration of fenprostalene could induce abortion during mid-pregnancy in bitches, and the subsequent estrus may come early with a low conception rate.

Oxidative stress in dogs during mid-gestation abortion: Fetal and maternal antioxidant alterations with clinical and hematological features

“…Safe and applicable methods consisting of inexpensive pharmacological agents for abortion are particularly desired. The administration of different abortifacients such as, prostaglandin F2α, dopamine agonists, dexamethasone and progesterone blockers were tested at different doses, alone or in combination for mid-gestation pregnancy termination in dogs (Kaya et al, 2014;Petterson and Tidholm, 2009;Galac et al, 2000;Cetin et al, 2000;Corrada et al, 2006;Hori et al, 2002;Gobello et al, 2002;Onclin and Verstegen, 1999;Feldman et al, 1993;Shille et al, 1984;Wanke et al, 1997;Zone et al, 1995;Onclin and Verstegen, 1996). Great oxygen consumption by feto-maternal unit and alterations in metabolic pathways are the reasons of increased oxidative stress during pregnancy period, leading imbalance between the formation of free radicals and the capacity for defense of the antioxidant mechanisms (Harma et al, 2004;Casanueva and Viteri, 2003;Vannucchi et al, 2007;Krieger and Loch-Caruso, 2001).…”

Influence of a PGF2.ALPHA.-Analogue, Etiproston Tromethamine, on the Functional Corpus Luteum of Dogs

“…To induce luteal regression-related abortion [2,4,5,8,18,21,22,27] and delivery [9,12,14] and to treat pyometra [13,16] in dogs, natural PGF 2α (PG) or its analogue (PGA) is used. As PG, dinoprost has been investigated [2,4,13,16,27].…”

“…As PG, dinoprost has been investigated [2,4,13,16,27]. As PGAs, several studies have investigated cloprostenol (PGA-C) [5,10,12], alphaprostol [21], PGF 2α -1052 (16-3-chlorophenoxy-ω-tetranor-trans-∆ 2 -PGF 2α methyl ester) [25,26], fenprostalene [7][8][9]14], and fluprostenol [10], but the types of PGA vary; it is being investigated which is most appropriate for promoting luteal regression in dogs. In clinical application, administration of PG or PGAs caused side effects such as salivation, vomiting, tachypnea, diarrhea, and drop in body temperature [2,5,7,9,25].…”