Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial

Tumlin, James A.; Dunbar, Lala M.; Oparil, Suzanne; Buckalew, Vardaman M.; Ram, C. Venkata S.; Mathur, Vandana; Ellis, David; McGuire, Dawn; Fellmann, J. D.; Luther, Robert R.

doi:10.1111/j.1553-2712.2000.tb02039.x

Cited by 68 publications

(20 citation statements)

References 32 publications

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“…In addition, sodium nitroprusside requires special handling to prevent its degradation by light. These factors limit the use of this drug (Tumlin et al 2000). …”

Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

152

110

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Perioperative hypertension is commonly encountered in patients that undergo surgery. While attempts have been made to standardize the method to characterize the intraoperative hemodynamics, these methods still vary widely. In addition, there is a lack of consensus concerning treatment thresholds and appropriate therapeutic targets, making absolute recommendations about treatment diffi cult. Nevertheless, perioperative hypertension requires careful management. When treatment is necessary, therapy should be individualized for the patient. This paper reviews the pharmacologic agents and strategies commonly used in the management of perioperative hypertension.

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“…In addition, sodium nitroprusside requires special handling to prevent its degradation by light. These factors limit the use of this drug (Tumlin et al 2000). …”

Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

152

110

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show abstract

“…After a starting dose of 0.1 ug/kg/min, the dose can be titrated every 15 minutes depending on BP response. Fenoldopam causes a dose-dependent BP decrease in the infusion range of 0.03 to 0.3 ug/kg/min [88]. In the postoperative setting, fenoldopam is effective in controlling BP following hypertensive episodes [89].…”

Section: Fenoldopammentioning

confidence: 99%

Perioperative hypertension: a review of current and emerging therapeutic agents,

Marik

Varon

2009

Journal of Clinical Anesthesia

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“…Fenoldopam selectively and preferentially stimulates the DA 1 receptor, resulting in vasodilatation. Intravenous infusion of fenoldopam results in a dose-related fall in systemic blood pressure [28,29], mainly through vasodilatation and to a small extent through natriuresis. Poor and variable absorption and erratic bioavailability have precluded the development of oral fenoldopam; the drug should be given as an infusion, not as a bolus.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Treatment of hypertensive urgencies and emergencies

Ram

Silverstein²

2009

Current Science Inc

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Although systemic hypertension is a common clinical condition, hypertensive emergencies are unusual in clinical practice. There are some situations, however, that qualify as hypertensive emergencies or urgencies. It is important, therefore, to diagnose these acute conditions, in which immediate treatment of hypertension is indicated. The diagnosis of hypertensive emergencies depends on consideration of the clinical manifestations as well as the absolute level of blood pressure. Manifestations of hypertensive emergencies can be quite profound, but they vary depending on the target organ that is affected. Thus, an accurate clinical diagnosis is necessary to render appropriate therapy. Fortunately, effective drug therapy is available to lower the blood pressure quickly in hypertensive emergencies. Physicians should be familiar with the pharmacologic and clinical actions of drugs in treating hypertensive emergencies. With proper clinical diagnosis, hypertensive emergencies can be successfully treated, and complications can be largely prevented with timely intervention.

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Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial

Abstract: Fenoldopam safely and effectively lowers blood pressure in a dose-dependent manner in patients with hypertensive emergencies. Observations supporting potential risk factors for hypertensive emergency are discussed.

Cited by 68 publications

References 32 publications

Perioperative hypertension management

Perioperative hypertension management

Perioperative hypertension: a review of current and emerging therapeutic agents,

Treatment of hypertensive urgencies and emergencies

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