Female Complexity: High ‘Natural’ Abo Anti-a Antibodies and Igg Class Switch in Female vs Male Mice

State-of-the-art Meeting on Sex and Gender in Transplantation: The Female Perspective

“…18 Preclinical mouse models suggest that the development of ABO blood group natural antibodies is significantly affected by sex and age, suggesting a potential role for sex hormones. 19,20 Mouse models allow the contribution of genes encoded in the sex chromosomes to be dissected from the impact of sex hormones and their receptors. 21 Furthermore, the sensitizing effects of pregnancy on humoral immunity contrasted with T cell tolerance to the allogeneic fetus was discussed, with implications for multiparous women who face reduced access to transplantation.…”

“…18 Preclinical mouse models suggest that the development of ABO blood group natural antibodies is significantly affected by sex and age, suggesting a potential role for sex hormones. 19,20 Mouse models allow the contribution of High-quality data to identify the proportion of transplant-eligible women and men on waitlists in different countries Understanding sex differences in pharmacokinetics and pharmacodynamics…”