Feeding performance in broiler chickens fed diets containing DAS-59122-7 maize grain compared to diets containing non-transgenic maize grain

McNaughton, James; Roberts, M.; Rice, David W.; Smith, Brenda; Hinds, M.; Schmidt, Jean M.; Locke, Mary; Bryant, Angela; Rood, Tracy; Layton, Raymond J.; Lamb, Ian; Delaney, Bryan

doi:10.1016/j.anifeedsci.2006.03.021

Cited by 33 publications

(20 citation statements)

References 11 publications

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“…This approach has also been used to compare the compositional and nutritional equivalence of transgenic crops with populations of non-transgenic crops [9, 10, 12, 19, 21, 24, 25, 35, 39, 44, 45]. However, large sample sizes are required to calculate tolerance intervals that are not so wide as to be of little practical value [36].…”

Section: Resultsmentioning

confidence: 99%

Safe composition levels of transgenic crops assessed via a clinical medicine model

Herman¹,

Scherer²,

Phillips³

et al. 2010

Biotechnology Journal

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Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.Substantial equivalence has become established as a foundation concept in the safety evaluation of transgenic crops. In the case of a food and feed crop, no single variety is considered the standard for safety or nutrition, so the substantial equivalence of transgenic crops is investigated relative to the array of commercial crop varieties with a history of safe consumption. Although used extensively in clinical medicine to compare new generic drugs with brand-name drugs, equivalence limits are shown to be a poor model for comparing transgenic crops with an array of reference crop varieties. We suggest an alternate model, also analogous to that used in clinical medicine, where reference intervals are constructed for a healthy heterogeneous population. Specifically, we advocate the use of distribution-free tolerance intervals calculated across a large amount of publicly available compositional data such as is found in the International Life Sciences Institute Crop Composition Database.

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Section: Resultsmentioning

confidence: 99%

Safe composition levels of transgenic crops assessed via a clinical medicine model

Herman¹,

Scherer²,

Phillips³

et al. 2010

Biotechnology Journal

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“…Additionally, there have also been a number of feeding studies in laboratory and farm animals such as poultry, swine and ruminants fed both either Bt microbial pesticides and/or Bt crops (Betz et al 2000;Flachowsky et al 2005aFlachowsky et al , b, 2007Federici and Siegel 2008;WHO/IPCS 1999;McClintock et al 1995;OECD 2007;Siegel 2001;Brake et al 2003;EFSA 2008;Scheideler et al 2008;McNaughton et al 2007;Taylor et al 2005Taylor et al , 2007. No evidence of adverse effects were reported in these studies as the animals responded similarly in growth and feed consumption to controls fed non-biotech derived crops.…”

Section: Toxicology Feeding Studies In Rodents Fed Bt Cropsmentioning

confidence: 98%

A Review of the Food Safety of Bt Crops

Hammond

Koch

2012

Bacillus Thuringiensis Biotechnology

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There is a 50-year history of safe use and consumption of agricultural food crops sprayed with commercial Bt ( Bacillus thuringiensis) microbial pesticides and a 14 year history of safe consumption of food and feed derived from Bt crops. This review summarizes the published literature addressing the safety of Cry insect control proteins found in both Bt microbial pesticides and those introduced into Bt agricultural crops. A discussion on the species-specific mode of action of Cry proteins to control target insect pests is presented. This information provides the scientific basis for the absence of toxicity of Cry proteins towards non-target organisms that has been confirmed in numerous mammalian toxicology studies. A human dietary exposure assessment for Cry proteins has also been provided which includes information that food processing of Bt crops such as maize leads to loss of functionally active Cry proteins in processed food products. Lastly the food and feed safety benefits of Bt crops are briefly summarized including lower insecticide use and reduction in fumonisin mycotoxin contamination of grain.

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“…Numerous feeding studies with 1-day-old broiler chicks have now been reported (Brake and Vlachos, 1998;Halle et al, 1999;Mireles et al, 2000;Sidhu et al, 2000;Aeschbacher et al, 2001;Gaines et al, 2001a;Taylor et al, 2001aTaylor et al, ,b, 2002Taylor et al, , 2003aTaylor et al, ,b,c, 2004aStanisiewski et al, 2002;Brake et al, 2003;Tony et al, 2003;Elangovan et al, 2003;Querubin et al, 2004;Kan and Hartnell, 2004a;Kan and Hartnell, 2004b;McNaughton et al, 2007). Numerous feeding studies with 1-day-old broiler chicks have now been reported (Brake and Vlachos, 1998;Halle et al, 1999;Mireles et al, 2000;Sidhu et al, 2000;Aeschbacher et al, 2001;Gaines et al, 2001a;Taylor et al, 2001aTaylor et al, ,b, 2002Taylor et al, , 2003aTaylor et al, ,b,c, 2004aStanisiewski et al, 2002;Brake et al, 2003;Tony et al, 2003;Elangovan et al, 2003;Querubin et al, 2004;Kan and Hartnell, 2004a;Kan and Hartnell, 2004b;McNaughton et al, 2007).…”

Section: Production Studies With Monogastric Livestockmentioning

confidence: 99%

Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials

2008

Food and Chemical Toxicology

171

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Feeding performance in broiler chickens fed diets containing DAS-59122-7 maize grain compared to diets containing non-transgenic maize grain

Cited by 33 publications

References 11 publications

Safe composition levels of transgenic crops assessed via a clinical medicine model

Safe composition levels of transgenic crops assessed via a clinical medicine model

A Review of the Food Safety of Bt Crops

Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials

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