Feeding-modulating neuropeptides and peptide hormones in insects

Nagata, Shinji; Zhou, Yi

doi:10.1016/bs.aiip.2019.10.002

Cited by 11 publications

(8 citation statements)

References 150 publications

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“…On the other hand, increased weight was observed only on the third day during the RNAi experiment and for the first 12 h during the peptide-treatment experiment; therefore, differences in growth rate cannot be reflected during such a short experimental period. In addition, as development and growth may be highly plastic, the growth abnormality caused by excessive or insufficient food consumption might be rescued by adjusting the efficiency of uptake of nutrients from the consumed and ingested food [36,37].…”

Section: Discussionmentioning

confidence: 99%

CCHamide-2 Signaling Regulates Food Intake and Metabolism in Gryllus bimaculatus

Zhu

Tsuchimoto

Nagata

2022

Insects

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Neuropeptides play vital roles in energy homeostasis in insects and other animals. Although the importance of the regulatory network of neuropeptides in feeding and metabolism has been illuminated, a complete understanding of the mechanisms has not been addressed as many factors are involved in the regulation. CCHamide-2 is a newly identified brain-gut neuropeptide that regulates feeding behavior in several insect species including Drosophila melanogaster. However, little is known about the mechanisms controlling the feeding-related behavior and metabolic functions modulated by CCHamide-2 in other insects. In this study, we addressed the functions of CCHamide-2 in the two-spotted cricket, Gryllus bimaculatus, which was used as the experimental material to research the mechanisms of feeding and metabolism in this omnivorous insect species. Knockdown crickets by RNA interference against GbCCHamide-2R increased the amount of food intake, while injection of chemically synthetic GbCCHamide-2 peptide reduced the amount of food intake. Further, knockdown and peptide injection experiments revealed that GbCCHamide-2 signaling increased the concentrations of circulating lipids and carbohydrates, and the carbohydrate-rich diet increased the transcript levels of GbCCHa-2R. Moreover, GbCCHa-2 injection decreased the transcript level of Gbilp. By contrast, GbCCHamide-2 signaling did not affect nymphal growth or the transcript level of GbAKH, as well as feeding preferences. Taken together, CCHamide-2 signaling in G. bimaculatus regulates food intake associated with alterations in lipid and carbohydrate levels in hemolymph.

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Section: Discussionmentioning

confidence: 99%

CCHamide-2 Signaling Regulates Food Intake and Metabolism in Gryllus bimaculatus

Zhu

Tsuchimoto

Nagata

2022

Insects

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“…Food seeking and feeding are under complex control by neuronal circuits as well as neuropeptides and peptide hormones 3,12,15,41,68,69,70,71 . Thus, sensory systems, central circuits and interorgan communication, in a nutrient-dependent fashion, contribute to feeding decisions and regulation of food ingestion.…”

Section: Discussionmentioning

confidence: 99%

Cholecystokinin-like Peptide Mediates Satiety by Inhibiting Sugar Attraction

Guo

Zhang

et al. 2020

Preprint

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Feeding is essential for animal survival and reproduction and is regulated by both internal states and external stimuli. However, little is known about how internal states influence the perception of external sensory cues that regulate feeding behavior. Here, we investigated the neuronal and molecular mechanisms behind nutritional state-mediated regulation of gustatory perception in control of feeding behavior in the brown planthopper and Drosophila. We found that feeding increases the expression of the cholecystokinin-like peptide, sulfakinin (SK), and the activity of a set of SK-expressing neurons. Starvation elevates the transcription of the sugar receptor Gr64f and SK negatively regulates the expression of Gr64f in both insects. This Gr64f regulation is by direct action of SK neurons on Gr64f-expressing neurons of the proboscis and proleg tarsi that co-express the SK receptor CCKLR-17D3. Our findings thus demonstrate how nutritional state induces peptide signaling to modulate sweet perception and thereby feeding behavior.

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“…Neuropeptides, as a class of crucial signaling molecules, regulate various physiological and behavioral processes in insects, including development, reproduction, feeding, courtship, learning, and so on. , Therefore, neuropeptides are usually considered as potential pesticide targets. Neuropeptides originate from larger precursor proteins, which are commonly expressed in the central nervous system as well as the digestive system. , Then, the precursors were produced into the bioactive mature peptides with diverse lengths .…”

Section: Introductionmentioning

confidence: 99%

Characterization of Neuropeptides from Spodoptera litura and Functional Analysis of NPF in Diet Intake

Yang,

Wang,

Deng

et al. 2024

J. Agric. Food Chem.

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Neuropeptides are involved in many biological processes in insects. However, it is unclear what role neuropeptides play in Spodoptera litura adaptation to phytochemical flavone. In this study, 63 neuropeptide precursors from 48 gene families were identified in S. litura, including two neuropeptide F genes (NPFs). NPFs played a positive role in feeding regulation in S. litura because knockdown of NPFs decreased larval diet intake. S. litura larvae reduced flavone intake by downregulating NPFs. Conversely, the flavone intake was increased if the larvae were treated with NPF mature peptides. The NPF receptor (NPFR) was susceptible to the fluctuation of NPFs. NPFR mediated NPF signaling by interacting with NPFs to regulate the larval diet intake. In conclusion, this study suggested that NPF signaling regulated diet intake to promote S. litura adaptation to flavone, which contributed to understanding insect adaptation mechanisms to host plants and provide more potential pesticidal targets for pest control.

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Feeding-modulating neuropeptides and peptide hormones in insects

Cited by 11 publications

References 150 publications

CCHamide-2 Signaling Regulates Food Intake and Metabolism in Gryllus bimaculatus

CCHamide-2 Signaling Regulates Food Intake and Metabolism in Gryllus bimaculatus

Cholecystokinin-like Peptide Mediates Satiety by Inhibiting Sugar Attraction

Characterization of Neuropeptides from Spodoptera litura and Functional Analysis of NPF in Diet Intake

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