Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers

Small, Dana M.; Jones‐Gotman, Marilyn; Dagher, Alain

doi:10.1016/s1053-8119(03)00253-2

Cited by 537 publications

(428 citation statements)

References 44 publications

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“…Moreover, dopamine has been implicated in multiple aspects of feeding behaviour including sensory components, learning, relaying physiological state, providing motivation, and finally, encoding nutrient content. Importantly, however, the participation of dopamine in feeding seems to be highly conserved and has been shown in a wide range of species including Drosophila [7], rats [8], mice [4], non-human primates [9], and humans [10].…”

Section: An Essential Role For Dopamine In Feedingmentioning

confidence: 99%

The role of dopamine in the pursuit of nutritional value

McCutcheon

2015

Physiology & Behavior

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Acquiring enough food to meet energy expenditure is fundamental for all organisms. Thus, mechanisms have evolved to allow foods with high nutritional value to be readily detected, consumed, and remembered. Although taste is often involved in these processes, there is a wealth of evidence supporting the existence of taste-independent nutrient sensing. In particular, post-ingestive mechanisms arising from the arrival of nutrients in the gut are able to drive food intake and behavioural conditioning. The physiological mechanisms underlying these effects are complex but are believed to converge on mesolimbic dopamine signalling to translate post-ingestive sensing of nutrients into reward and reinforcement value. Discerning the role of nutrition is often difficult because food stimulates sensory systems and post-ingestive pathways in concert. Thus, in this mini-review, I discuss the various methods that may be used to study post-ingestive processes in isolation including sham-feeding, nonnutritive sweeteners, post-ingestive infusions, and pharmacological and genetic methods. Using this structure, I present the evidence that dopamine is sensitive to nutritional value of certain foods and examine how this affects learning about food, the role of taste, and the implications for human obesity.

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Section: An Essential Role For Dopamine In Feedingmentioning

confidence: 99%

The role of dopamine in the pursuit of nutritional value

McCutcheon

2015

Physiology & Behavior

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“…Our group recently reported that remitted AN had evidence of increased Dopamine (DA) D2/D3 receptor binding in the anterior ventral striatal regions . DA has been reported to be released in response to taste of food in animals and humans (Mirenowicz and Schultz, 1994;Schultz, 1998;Small et al, 2003b). Thus it is possible that remitted AN have an altered DA response to feeding.…”

Section: Image Analysismentioning

confidence: 99%

Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa

Wagner

Aizenstein

Mazurkewicz

et al. 2007

Neuropsychopharmacol

236

203

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Anorexia nervosa (AN) is an illness characterized by aversion to ingestion of normally palatable foods. We examined whether there is a primary disturbance of taste processing and experience of pleasure using a sucrose/water task in conjunction with functional magnetic resonance imaging (fMRI). To avoid confounding effects of illness, 16 women recovered from restricting-type AN were compared to 16 control women (CW). We used a region of interest-based fMRI approach to test the idea that individuals with AN have differential neural activation in primary and secondary taste cortical regions after sucrose and water administration. Compared to CW, individuals recovered from AN showed a significantly lower neural activation of the insula, including the primary cortical taste region, and ventral and dorsal striatum to both sucrose and water. In addition, insular neural activity correlated with pleasantness ratings for sucrose in CW, but not in AN subjects. Altered taste processing may occur in AN, based on differences in activity in insular-striatal circuits. These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns.

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“…Moreover, the amount of DA released after consuming a preferred meal eventually correlates with the degree of experienced pleasure (Small, Jones‐Gotman, & Dagher, 2003). Thus, disruption of DA activity can lead to loss of control over intake and continued consumption despite negative consequences, being both behaviors commonly seen in addiction and obesity (Volkow, Wang, Tomasi, & Baler, 2013).…”

Section: Introductionmentioning

confidence: 99%

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

et al. 2018

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IntroductionDopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hypothesized associations of DNA methylation signatures at genes modulating DA signaling with obesity features, metabolic profiles, and dietary intake.MethodsAn adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened.ResultsAfter applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p < 0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (CACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the presence or absence of abdominal obesity. Pathway analyses revealed a statistically significant contribution of the aforementioned genes to dopaminergic synapse transmission (p = 4.78E−08). Furthermore, SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p < 0.001) and carbohydrate (p < 0.001) intakes.ConclusionsThe results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition.

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Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers

Cited by 537 publications

References 44 publications

The role of dopamine in the pursuit of nutritional value

The role of dopamine in the pursuit of nutritional value

Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa

Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

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