Fecal Microbiota Transplantation in Neurological Disorders

Vendrik, Karuna E.W.; Ooijevaar, Rogier E.; Jong, Pieter R. C. de; Laman, Jon D.; Oosten, Bob W. van; Hilten, Jacobus J. van; Ducarmon, Quinten R; Keller, Josbert J.; Kuijper, E.; Contarino, Maria Fiorella

doi:10.3389/fcimb.2020.00098

Cited by 223 publications

(144 citation statements)

References 228 publications

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“…Currently, FMT has been clinically shown to be effective for treating intestinal diseases, such as Clostridium difficile infection and inflammatory bowel disease. 121 Some parenteral diseases are also being explored, such as autism, 122 obesity, 123 and type 2 diabetes. 124 Vrieze et al 125 performed FMT treatment on patients with metabolic syndrome, and the result indicated that patients receiving gut flora from leptin donor displayed improved insulin sensitivity and increased butyrate production.…”

Section: Tang Et Al (2013) 133mentioning

confidence: 99%

TMAO: how gut microbiota contributes to heart failure

Zhang

Wang

et al. 2021

Translational Research

117

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An increasing amount of evidence reveals that the gut microbiota is involved in the pathogenesis and progression of various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia and intestinal edema, allowing bacterial translocation and bacterial metabolites to enter the blood circulation via an impaired intestinal barrier. This results in local and systemic inflammatory responses. Gut microbe-derived metabolites are implicated in the pathology of multiple diseases, including HF. These landmark findings suggest that gut microbiota influences the host's metabolic health, either directly or indirectly by producing several metabolites. In this review, we mainly discuss a newly identified gut microbiota-dependent metabolite, trimethylamine N-oxide (TMAO), which appears to participate in the pathologic processes of HF and can serve as an early warning marker to identify individuals who are at the risk of disease progression. We also discuss the potential of the gutÀTMAOÀHF axis as a new target for HF treatment and highlight the current controversies and potentially new and exciting directions for future research.

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Section: Tang Et Al (2013) 133mentioning

confidence: 99%

TMAO: how gut microbiota contributes to heart failure

Zhang

Wang

et al. 2021

Translational Research

117

View full text Add to dashboard Cite

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“…Finally, FMT may be an alternative strategy to tackle dysbiosis in neurodegenerative diseases. Anecdotal reports of FMT use in PD have been reported, which prompted the design of randomized clinical trials [ 386 ]. In addition, a multicenter trial evaluating the efficacy of FMT in ALS (FETR-ALS) is ongoing, which will assess possible changes in gut microbiota and effects on clinical outcomes [ 387 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

Gentile

Doneddu

Riva

et al. 2020

IJMS

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Increasing evidence gives support for the idea that extra-neuronal factors may affect brain physiology and its predisposition to neurodegenerative diseases. Epidemiological and experimental studies show that nutrition and metabolic disorders such as obesity and type 2 diabetes increase the risk of Alzheimer’s and Parkinson’s diseases after midlife, while the relationship with amyotrophic lateral sclerosis is uncertain, but suggests a protective effect of features of metabolic syndrome. The microbiota has recently emerged as a novel factor engaging strong interactions with neurons and glia, deeply affecting their function and behavior in these diseases. In particular, recent evidence suggested that gut microbes are involved in the seeding of prion-like proteins and their spreading to the central nervous system. Here, we present a comprehensive review of the impact of metabolism, diet and microbiota in neurodegeneration, by affecting simultaneously several aspects of health regarding energy metabolism, immune system and neuronal function. Advancing technologies may allow researchers in the future to improve investigations in these fields, allowing the buildup of population-based preventive interventions and development of targeted therapeutics to halt progressive neurologic disability.

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“…The evidence on the role of the gut microbiota on AD includes direct actions of bacteria as well as indirect actions or aging-related processes [ 91 , 92 ]. In light of this, recent studies have shown that bacteria are involved in the pathology of AD by altering the permeability of the BBB and, thereby, facilitating an overproduction and aggregation of Aβ.…”

Section: Oral and Gut Microbiota In Alzheimer’s Diseasementioning

confidence: 99%

“…Finally, preliminary literature suggests that fecal microbiota transplantation, considered currently, as the most effective gut microbiota intervention for recurrent Clostridioides difficile infections, may be a promising treatment option for several neurological dysfunctions [ 92 ]. In fact, some studies suggested a beneficial effect of fecal microbiota transplantation from young healthy donors, but evidence was restricted to a limited number of animal model studies.…”

Section: Oral and Gut Microbiota In Alzheimer’s Diseasementioning

confidence: 99%

Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

et al. 2020

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to the most common form of dementia in elderly people. Modifiable dietary and lifestyle factors could either accelerate or ameliorate the aging process and the risk of developing AD and other age-related morbidities. Emerging evidence also reports a potential link between oral and gut microbiota alterations and AD. Dietary polyphenols, in particular wine polyphenols, are a major diver of oral and gut microbiota composition and function. Consequently, wine polyphenols health effects, mediated as a function of the individual’s oral and gut microbiome are considered one of the recent greatest challenges in the field of neurodegenerative diseases as a promising strategy to prevent or slow down AD progression. This review highlights current knowledge on the link of oral and intestinal microbiome and the interaction between wine polyphenols and microbiota in the context of AD. Furthermore, the extent to which mechanisms bacteria and polyphenols and its microbial metabolites exert their action on communication pathways between the brain and the microbiota, as well as the impact of the molecular mediators to these interactions on AD patients, are described.

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Fecal Microbiota Transplantation in Neurological Disorders

Cited by 223 publications

References 228 publications

TMAO: how gut microbiota contributes to heart failure

TMAO: how gut microbiota contributes to heart failure

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease

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