Fecal microbiota transplantation for treatment of patients with recurrent <i>Clostridioides difficile</i> infection

Voth, Elida; Khanna, Sahil

doi:10.1080/14787210.2020.1752192

Cited by 19 publications

(20 citation statements)

References 54 publications

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“…The overall risk of recurrence after a second recurrence is greater than 50% with antibiotic therapy. Case series and clinical trials have demonstrated a greater than 85% success rate with microbiome restoration overall to prevent recurrent CDI in this high-risk population [1].…”

Section: Antibiotic Management Of C Difficile Infectionmentioning

confidence: 97%

“…Clostridioides difficile is an urgent public health threat by virtue of being the most common pathogen in hospitals and an increased risk of community-acquired infection [1]. The incidence of Clostridioides difficile infection (CDI) is increasing with a disproportionate rise in recurrent CDI seen in the United States.…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of Clostridioides difficile infection (CDI) is increasing with a disproportionate rise in recurrent CDI seen in the United States. The primary risk factors for CDI are antibiotic exposure, advanced age, presence of comorbid conditions such as immunosuppression, inflammatory bowel disease, chronic kidney disease, amongst others [1]. The pathophysiology of both primary and recurrent CDI includes a disruption of the gut microbiota, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…The clinical features of CDI range from diarrhea, abdominal pain, fever to fulminant colitis with severe sepsis. The cornerstone of the management of initial CDI is an antibiotic therapy and multiply recurrent CDI is managed with microbiome restoration therapies to restore gut dysbiosis [1]. This article discusses recent advances in the diagnosis and therapy of primary and recurrent CDI.…”

Section: Introductionmentioning

confidence: 99%

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Advances in Clostridioides difficile therapeutics

Khanna

2021

Expert Review of Anti-infective Therapy

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Section: Antibiotic Management Of C Difficile Infectionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advances in Clostridioides difficile therapeutics

Khanna

2021

Expert Review of Anti-infective Therapy

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“…Gut microbiota encodes over three million genes producing thousands of metabolites with diverse roles, including extraction, synthesis, and absorption of many nutrients and metabolites [ 81 ]. Gut microbiota also shows an immune function against pathogenic bacteria colonization and promotes intestinal epithelium integrity [ 82 , 83 , 84 ]. It implies a wide range of microorganisms, being the dominant phyla Firmicutes and Bacteroidetes , which represents 90 percent of gut microbiota.…”

Section: Ad-t2dm Relationshipmentioning

confidence: 99%

Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models

et al. 2021

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Alzheimer’s disease (AD) is the most common cause of dementia. Epidemiological studies show the association between AD and type 2 diabetes (T2DM), although the mechanisms are not fully understood. Dietary habits and lifestyle, that are risk factors in both diseases, strongly modulate gut microbiota composition. Also, the brain-gut axis plays a relevant role in AD, diabetes and inflammation, through products of bacterial metabolism, like short-chain fatty acids. We provide a comprehensive review of current literature on the relation between dysbiosis, altered inflammatory cytokines profile and microglia in preclinical models of AD, T2DM and models that reproduce both diseases as commonly observed in the clinic. Increased proinflammatory cytokines, such as IL-1β and TNF-α, are widely detected. Microbiome analysis shows alterations in Actinobacteria, Bacteroidetes or Firmicutes phyla, among others. Altered α- and β-diversity is observed in mice depending on genotype, gender and age; therefore, alterations in bacteria taxa highly depend on the models and approaches. We also review the use of pre- and probiotic supplements, that by favoring a healthy microbiome ameliorate AD and T2DM pathologies. Whereas extensive studies have been carried out, further research would be necessary to fully understand the relation between diet, microbiome and inflammation in AD and T2DM.

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