Features of the choriocapillaris on four different optical coherence tomography angiography devices

Yun, Cheolmin; Nam, Ki Tae; Park, Seoyeon; Hwang, Soon Young; Oh, Jaeryung

doi:10.1007/s10792-019-01182-w

Cited by 14 publications

(23 citation statements)

References 31 publications

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“…Similarly, numerous investigations have reported dark regions in OCTA CC scans, the so-called flow voids, in association with various chorioretinal diseases such as diabetic retinopathy [18], age-related macular degeneration [19] and CSC [8,17] suggesting that they represent potentially disease-relevant hypoperfusion in the CC. However, the comparison of SS-OCTA and SD-OCTA in our study suggests that detecting a reduced CC OCTA signal in the presence of SRF with SD-OCTA is at least partially artificial and may have been [10,20].…”

Section: Discussionmentioning

confidence: 61%

“…Several studies have been conducted comparing SD with SS-OCT imaging [5,10,20,21], all showing an advantage of SS-OCT when imaging beyond the retinal layers. Compared to the other mentioned studies, our study distinguishes between areas with and without SRF.…”

Section: Discussionmentioning

confidence: 99%

“…SS-OCTA led to a more homogeneous OCTA CC architecture in health and disease and to a decline in the diminished OCTA signal in the SRF range compared to SD-OCTA. This is attributable to the use of a longer wavelength, which reduces scattering and absorption caused by SRF, thus allowing deeper light penetration and improved visualization of OCTA flow in deeper tissue [ 10 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…While several studies have compared SD-OCTA and SS-OCTA in healthy patients [9,10] and chorioretinal diseases [11], none has explicitly investigated the effects of SRF on the CC OCTA signal in both devices. Since SS-OCTA allows deeper light penetration and improved visualization of OCTA flow in deeper tissue [9], scattering and absorption caused by SRF might be reduced.…”

Section: Introductionmentioning

confidence: 99%

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Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid

et al. 2020

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Purpose To characterize the choriocapillaris (CC) structure in relation to subretinal fluid (SRF) as a possible systematic error source using spectral domain (SD-OCTA) compared to swept-source optical coherence tomography angiography (SS-OCTA). Methods This is a prospective case-control study of 23 eyes. Ten patients with acute central serous chorioretinopathy (CSC), three patients with partial macular-off retinal detachment (RD) and ten healthy, age-matched controls were included. Abnormal CC decorrelation signals were quantitatively compared in CSC and controls by means of custom image processing. To investigate the influence of SRF on CC OCTA signal, the extent of SRF was quantified with a macular heatmap and compared with the corresponding OCTA signal of the CC. Results SS-OCTA yielded a more homogeneous OCTA signal from the CC than SD-OCTA, offering less signal dispersion and variability in healthy and diseased eyes. Both devices demonstrated CC signal voids in CSC and RD, respectively. In CCS, the voids were predominantly located in the area with SRF. Compared to SD-OCTA, SS-OCTA delivered a more homogenous OCTA signal and reduced signal voids in the CC underneath SRF in both RD and CSC (CSC, 7.6% ± 6.3% vs, 19.7% ± 9.6%, p \ 0.01). Despite this significant attenuation of signal voids, SS-OCTA continued to reveal signal voids below SRF and more pixels with reduced OCTA signals in CSC patients compared to controls (7.6% ± 6.3%, 0.1% ± 0.1%, p \ 0.0001). Conclusion Understanding OCTA artifacts is critical to ensure accurate clinical evaluations. In this study, we describe the presence of SRF as an important shadow-causing artifact source for CC OCTA analysis which can be mitigated but not completely eliminated by employing SS-OCTA.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid

et al. 2020

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“…This has been shown by studies that have compared SS-OCTA and SD-OCTA imaging. 23,24 Moreover, image quality may be reduced by prolonged duration of imaging with lower scanning speed and consecutive drying of the patient's eye surface. 25 Finally, only two different devices were compared and the results cannot be generalized to other SS-OCTA or SD-OCTA devices.…”

Section: A B C Dmentioning

confidence: 99%

<p>Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography</p>

Faatz

Rothaus

Ziegler

et al. 2020

OPTH

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The aim of this study was to ascertain and quantify the differences between sweptsource (SS) and spectral-domain (SD) optical coherence tomography angiography (OCTA) imaging of macular neovascularizations (MNV) in neovascular age-related macular degeneration (nAMD). Patients and Methods: SD-OCTA (RTVue Avanti) and SS-OCTA (PLEX ® Elite 9000) were performed in 37 patients with MNV in nAMD. The MNV was delineated and the data were processed via ImageJ. The parameters MNV area, nodes per area, fractal dimension (FD), and flow density were analyzed using MatLab. Results: There was close agreement between the two devices regarding MNV area (ICCc 0.977, ICCa 0.977, R 2 0.977), but only slight agreement regarding nodes per area (ICCa 0.008, ICCc 0.548, R 2 0.51), FD (ICCa 0.425, ICCc 0.846, R 2 0.96), and flow density (ICCa 0.451, ICCc 0.656, R 2 0.65). The difference between the two devices was insignificant for MNV area (type 1: p=0.328; type 2: p=0.426; type 3: p=0.615), but significant for nodes per area (type 1: p=0.002; type 2: p=0.00001; type 3: p=0.003), FD (type 1: p<0.00001; type 2: p<0.00001; type 3: p=0.015) and flow density (type 1: p=0.0004; type 2: p=0.004; type 3: p=0.052). Conclusion: MNV area is closely comparable between devices using SS-OCTA and SD-OCTA imaging. However, the two methods differ significantly in their precise assessment of the vascular morphology (FD, flow density, nodes per area). Therefore, results obtained using different devices are not comparable and should not be amalgamated in clinical trials.

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Hyperreflective foci in the choroid of normal eyes

Kim

2021

Graefes Arch Clin Exp Ophthalmol

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Features of the choriocapillaris on four different optical coherence tomography angiography devices

Cited by 14 publications

References 31 publications

Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid

Swept-source optical coherence tomography angiography alleviates shadowing artifacts caused by subretinal fluid

<p>Quantitative Comparison of the Vascular Structure of Macular Neovascularizations Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography</p>

Hyperreflective foci in the choroid of normal eyes

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