Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus

Lim, Hyun; Park, Young Soo; Lee, Jeong Hoon; Son, Da Hye; Ahn, Ji Yong; Choi, Kwi-Sook; Kim, Do Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Jung, Hwoon‐Yong; Kim, Jin-Ho; Yook, Jeong Hwan; Kim, Byung Sik

doi:10.1016/j.cgh.2015.04.015

Cited by 54 publications

(55 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, EBV infection is the most important prognosis factor in GCLS but not the cancer cell morphology. 13 This study supported that EBV-positive and EBV-negative GCLS are 2 different entities.…”

Section: Epstein-barr Virus Status As a Key Prognostic Factor In Gastsupporting

confidence: 65%

See 1 more Smart Citation

Are Epstein-Barr Virus-positive and -negative Gastric Carcinomas, With Lymphoid Stroma, Single Entity or Different Entities?

Kang

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Section: Epstein-barr Virus Status As a Key Prognostic Factor In Gastsupporting

confidence: 65%

“…However, in view of the prognostic implication as revealed by the literature, EBV status in GC may serve as a clinically useful prognostic marker. 13 EBV status may also have potential therapeutic implications.…”

Section: The Epstein-barr Virus Test In Gastric Cancermentioning

confidence: 99%

Are Epstein-Barr Virus-positive and -negative Gastric Carcinomas, With Lymphoid Stroma, Single Entity or Different Entities?

Kang

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…Helicobacter pylori, EBV is accepted as an infective agent that plays an important pathogenic role in gastric cancer (2,3). Gastric carcinoma with lymphoid stroma (GCLS) is a rare histological subgroup of gastric cancers, constituting approximately 1-4% of all gastric carcinomas.…”

Section: Epstein-barr Virus (Ebv) Is An Established Cause Of Various mentioning

confidence: 99%

Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma, accompanied with lymph node metastasis

et al. 2018

View full text Add to dashboard Cite

Abstract. The present case report presents a rare case of Epstein-Barr virus (EBV)-associated early gastric carcinoma with lymphoid stroma, accompanied by lymph node metastasis. A 61-year-old woman was referred to our hospital following observation of a gastric mass lesion that was initially diagnosed at a medical check-up. Esophagogastroduodenoscopy revealed a slightly elevated lesion with a central irregular depression in the middle third of the stomach. Endoscopic ultrasonography revealed a well-circumscribed hypoechoic mass located predominantly within the submucosa and the mucosa. Biopsy specimens of the lesion indicated the possibility of carcinoma with lymphoid stroma with a lymphoepithelial lesion. Abdominal contrast-enhanced computed tomography (CT) revealed a well-defined mass with homogeneous enhancement approximately 1.2 cm in diameter in the middle part of the stomach, demonstrating lymphadenopathy in the perigastric area at a maximum size of 1.4 cm in diameter. The patient underwent laparoscopic distal gastrectomy with regional lymphadenectomy due to suspicion of a gastric carcinoma with lymphoid stroma. Histopathological and immunohistochemical findings verified the diagnosis of carcinoma with lymphoid stroma, which were positive for EBV-encoded RNA (EBER-ISH) by in situ hybridization. There was one lymph node metastasis, which was in line with the CT imaging. Marked infiltration of lymphoid cells was observed in the tumor stroma, which were negative for EBER-ISH. The present case is informative of the pathological characteristics of this condition, and clinicians should recognize the features of this disease to make an accurate diagnosis and select the appropriate treatment.

show abstract

“…However, a recent meta-analysis of 4599 GC cases identified a decreased mortality rate in EBVaGC following adjustment for the cancer stage and other factors (24). The 10-year disease-specific rate of patients with EBVaGCLS (89.1%) was previously demonstrated to be significantly increased compared with that of EBV-non-associated GCLS (66.9%) (P=0.009) (4). These results suggest that the EBV infection status in GC is an important prognostic factor.…”

Section: Discussionmentioning

confidence: 94%

“…The LELC type is also referred to as ‘GC with lymphoid stroma (GCLS)’. In total, >80% of GCLS cases have been identified to exhibit EBV(+) tumors (3,4). …”

Section: Introductionmentioning

confidence: 99%

Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers

et al. 2017

View full text Add to dashboard Cite

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma-like histology. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related nuclear factor κB (NF-κB) signaling in Helicobacter pylori-associated gastric cancer. To elucidate whether or not AID expression is relevant to carcinogenesis in EBVaGC, immunohistochemical expression of AID and AID-regulatory factors between EBVaGC and EBV-non-associated gastric carcinoma (GC) were evaluated, each using 15 cases of GC with lymphoid stroma (GCLS) and other types of GC. Aberrant expression of AID, NF-κB and paired box 5 (PAX5) were significantly decreased in EBVaGC (0/11, 1/11 and 1/11) compared with in EBV-non-associated GC (7/19, 12/19 and 11/19) (P=0.025, 0.005 and 0.01, respectively); however, no significant difference in c-Myb proto-oncogene expression was identified. AID expression was also decreased in EBV-associated GCLS (0/10) compared with in EBV-non-associated GCLS (3/5). Unexpectedly, decreased expression of NF-κB and PAX5 was observed in GCLS (1/15 and 2/15) compared with in GC without LS (12/15 and 10/15) (P<0.001 and P=0.003, respectively). Decreased AID expression observed in EBVaGC is consistent with the reported molecular characterization of hypermethylation and rare somatic gene mutation in EBVaGC. Only PAX5 was identified to be significantly associated with venous invasion (P=0.022). The results of the present study suggest that pathogen-induced AID expression may be irrelevant to carcinogenesis of EBVaGC, whereas it contributes to carcinogenesis in certain types of EBV-non-associated GC.

show abstract

Features of Gastric Carcinoma With Lymphoid Stroma Associated With Epstein-Barr Virus

Cited by 54 publications

References 23 publications

Are Epstein-Barr Virus-positive and -negative Gastric Carcinomas, With Lymphoid Stroma, Single Entity or Different Entities?

Are Epstein-Barr Virus-positive and -negative Gastric Carcinomas, With Lymphoid Stroma, Single Entity or Different Entities?

Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma, accompanied with lymph node metastasis

Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers

Contact Info

Product

Resources

About