Feasibility Study of Superficial Hyperthermia Treatment Planning Using COMSOL Multiphysics

Performance characteristics of a conformal ultra‐wideband multilayer applicator (CUMLA) for hyperthermia in veterinary patients: a pilot evaluation of its use in the adjuvant treatment of non‐resectable tumours

“…However, at the working frequency of 915 MHz, the bandwidth of the spiral array is less than 50 MHz with an average return loss of −8.2 dB 19 . The CUMLA incorporates a slot‐antenna and multi‐layer construct to improve bandwidth performance 14,32 . Simulation results show a bandwidth of >350 MHz at a centre frequency of 434 MHz and were in general agreement with measured results (Fig.…”

“…The resultant increased voltage standing wave seen with a simple flat antenna would require the use of a water bolus to provide effective cooling of the skin surface and avoid superficial toxicity. Traditional microstrip and waveguide applicators for superficial hyperthermia also require the use of a water bolus for a variety of reasons including high return loss values 5–7,14,39,32,33 . The skin sparing effect of the multi‐layer construct described herein requires no such water bolus for clinical use.…”

“…Patients with biochemical evidence of renal insufficiency received a minimal dosage reduction of 25%. These dose levels were established through clinical use at UTCVM and are slightly lower than those reported previously in dose escalation studies in dogs and cats 32,33 . In an attempt to achieve uniform distribution of chemotherapy in these patients, the dosage was delivered in a parallel‐row fashion with multiple planes used for larger tumours 19,31 .…”