Feasibility of two-dimensional ultrasound shear wave elastography of human fetal lungs and liver: A pilot study

Mottet, Nicolas; C, Cochet; Vidal, Chrystelle; Metz, Jean; Aubry, S.; Bourtembourg, A.; Eckman-Lacroix, Astrid; Riethmuller, Didier; Pazart, Lionel; Ramanah, R.

doi:10.1016/j.diii.2019.08.002

Cited by 8 publications

(5 citation statements)

References 40 publications

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“…Previous studies used quantitative ultrasonographic methods to show lung maturation; however, there were some limitations and uncertainties 10,11 . Quarello et al, 18 who studied with fetal baboon lungs, and Mottet et al, 19 who studied with human fetal lung and liver, both used shear wave elastography and found out significant differences. However, VTTQ elastographic measurements were very few in the literature 20 …”

Section: Discussionmentioning

confidence: 99%

Use of Virtual Touch Tissue Quantification Elastography Technique in Fetal Lung Maturation

Arslan¹,

Küçükbaş

Türkoğlu

et al. 2023

Ultrasound Quarterly

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This study is an analysis of fetal lung stiffness by virtual touch tissue quantification (VTTQ) elastography to predict fetal lung maturation. Evaluation of fetal lungs was first performed in B mode, and fetal lungs were analyzed at 3 different periods at third trimester in each pregnant woman, at 28 to 31, 32 to 36, and 37 to 41 weeks. Fetal lung elastography was performed at regions with the least acoustic shadow and far from ribs and heart. Each fetal lung assessment were done by taking mean lung stiffness obtained by measuring stiffness of both left and right fetal lungs. T test analysis showed no significant difference in fetal lung stiffness between male and female fetuses among 3 gestational periods. Analysis of variance was performed to evaluate fetal lung stiffness of the fetuses at 3 different gestational periods (28-31, 32-36, and 37-41 weeks). This analysis showed significant difference ( P < 0.01). Duncan multiple comparison analysis did not show significant difference in fetal lung stiffness between 28 and 31 weeks and 32 and 36 weeks, whereas fetal lung stiffness of fetuses at 37 to 41 weeks were significantly greater ( P < 0.01). This study is first step to analyze fetal lung maturation noninvasively using VTTQ elastography technique by measuring fetal lung stiffness.

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Section: Discussionmentioning

confidence: 99%

Use of Virtual Touch Tissue Quantification Elastography Technique in Fetal Lung Maturation

Arslan¹,

Küçükbaş

Türkoğlu

et al. 2023

Ultrasound Quarterly

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“…In our preliminary study, neonatal hypoacusis screening tests were normal for 100 infants exposed to 2D-SWE during the prenatal period. In one case, otoacoustic emissions were not registered in the medical file, and one infant presented abnormal AEP for one ear in one case of premature delivery at 31 WG [ 14 ]. With this complementary study, we confirmed that no adverse neonatal outcomes were observed in 70 new infants exposed prenatally to 2D-SWE, and 94.2% (66/70) of them had a negative result in the audiologic tests.…”

Section: Discussionmentioning

confidence: 99%

“…Trajectories representing the evolution of the foetal lung and liver maturation from at least 3 measurements over time were modelled (24, 28, 32, 36 and 39 WG). The calculation of the effect was carried out from preliminary data obtained in the ELASTOMAP study in a cohort of patients not at risk of preterm delivery [ 14 ]. The assumptions underlying the calculation were that a relatively precise estimate (± 5% around the observed values) of the average trajectory with its 95% confidence interval is desired to identify atypical trajectories.…”

Section: Methodsmentioning

confidence: 99%

“…In a preliminary pilot study (the ELASTOMAP study), we concluded that quantitative foetal lung and liver stiffness measurements during gestation were feasible using 2D-SWE with acceptable reproducibility [ 14 ]. We explored both the foetal lung and liver because the latter has been used as a reference organ to assess foetal lung maturity in several studies using ultrasound or MRI [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Prenatal quantification of human foetal lung and liver elasticities between 24 and 39 weeks of gestation using 2D shear wave elastography

Nallet

Pazart

et al. 2022

Eur Radiol

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Objectives To quantify and model normal foetal lung and liver elasticities between 24 and 39 weeks of gestation (WG) using two-dimensional shear wave elastography (2D-SWE). To assess the impact of the distance between the probe and the target organ on the estimation of elasticity values. Methods Measurements of normal foetal lungs and liver elasticity were prospectively repeated monthly between 24 and 39 WG in 72 foetuses using 2D-SWE. Elasticity was quantified in the proximal lung and in the region inside the hepatic portal sinus. The distance between the probe and the target organ was recorded. Trajectories representing foetal lung and liver maturation from at least 3 measurements over time were modelled. Results The average elasticity for the lung and liver was significantly different from 24 WG to 36 WG (p < 0.01). Liver elasticity increased during gestation (3.86 kPa at 24 WG versus 4.45 kPa at 39 WG). From 24 WG to 32 WG, lung elasticity gradually increased (4.12kPa at 24 WG, 4.91kPa at 28 WG, 5.03kPa at 32 WG, p < 0.002). After 32 WG, lung elasticity decreased to 4.54kPa at 36 WG and 3.94kPa at 39 WG. The dispersion of the average elasticity values was greater for the lung than for the liver (p < 0.0001). Variation in the elasticity values was less important for the liver than for the lung. The values were considered valid and repeatable except for a probe-lung distance above 8cm. Conclusion Foetal lung and liver elasticities evolve differently through gestation. This could reflect the tissue maturation of both organs during gestation. Trial registration clinicaltrials.gov identifier: NCT03834805 Key Points • Prenatal quantification of foetal lung elasticity using 2D shear wave elastography could be a new prenatal parameter for exploring foetal lung maturity. • Liver elasticity increased progressively from 24 weeks of gestation (WG) to 39 WG, while lung elasticity increased first between 24 and 32 WG and then decreased after 32 WG. • The values of elasticity are considered valid and repeatable except for a probe-lung distance above 8cm.

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“…SWE assessed fetal lung and liver elastography (LLE), and the results showed that there was no difference in LLE values between the two groups at “day 0,” but the LLE values decreased at “day 2” in the case group (0.2; 95% confidence interval: 0.07–0.34; p < 0.001). The repeatability and reproducibility of the measurement were calculated, and the results were acceptable [ 86 , 87 ]. SWE could be considered a new non-invasive, reproducible tool for monitoring fetal lung development by assessing mechanical properties during pregnancy.…”

Section: Predicting Preterm Deliverymentioning

confidence: 99%

Advances in the clinical application of ultrasound elastography in uterine imaging

Wang

Lin

2022

Insights Imaging

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Changes in tissue stiffness by physiological or pathological factors in tissue structure are identified earlier than their clinical features. Pathological processes such as uterine fibrosis, adenomyosis, endometrial lesions, infertility, and premature birth can manifest as tissue elasticity changes. In clinical settings, elastography techniques based on ultrasonography, optical coherence tomography, and magnetic resonance imaging are widely used for noninvasive measurement of mechanical properties in patients, providing valuable tool and information for diagnosis and treatment. Ultrasound elastography (USE) plays a critical role in obstetrics and gynecology clinical work because of its simplicity, non-invasiveness, and repeatability. This article reviews the recent progress of USE in uterine tumor diagnosis (especially early diagnosis and treatment effect evaluation), prediction of preterm birth, and intrauterine insemination. We believe that USE, especially shear wave elastography, may serve as a potential means to assess tissue stiffness, thereby improving the diagnosis and treatment of adenomyosis, fibroids, endometrial lesions, cervical cancer, and precise management of preterm birth and intrauterine insemination monitoring.

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Feasibility of two-dimensional ultrasound shear wave elastography of human fetal lungs and liver: A pilot study

Cited by 8 publications

References 40 publications

Use of Virtual Touch Tissue Quantification Elastography Technique in Fetal Lung Maturation

Use of Virtual Touch Tissue Quantification Elastography Technique in Fetal Lung Maturation

Prenatal quantification of human foetal lung and liver elasticities between 24 and 39 weeks of gestation using 2D shear wave elastography

Advances in the clinical application of ultrasound elastography in uterine imaging

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