Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson’s Disease

Jeong, Eugene; Oh, Sun Young; Pahk, Kisoo; Lee, Chan Nyoung; Park, Kun Woo; Lee, Jae Sung; Cheon, Gi Jeong; Choe, Jae Gol

doi:10.1007/s13139-013-0196-6

Cited by 15 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 F‐FP‐CIT PET/CT scans were performed using a methodology described previously (Jeong et al, ). Patients were intravenously injected with 18 F‐FP‐CIT (185 MBq), and PET/CT was performed 3 h after injection using a PET/CT scanner (Biograph 6 TruePoint True V, Siemens Medical Solutions).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Lee

Kim

Park

et al. 2018

Synapse

View full text Add to dashboard Cite

I-FP-CIT and F-FP-CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head-to-head comparisons between I-FP-CIT and F-FP-CIT. Therefore, in this study, I-FP-CIT SPECT/CT was compared with F-FP-CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between I-FP-CIT SPECT/CT and F-FP-CIT PET/CT showed a positive correlation (r = .78, p< .01). However, the mean SBRs on F-FP-CIT PET/CT were higher than those on I-FP-CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p < .01). The PCRs in these two modalities were correlated with each other (r = .71, p < .01). The mean PCRs on F-FP-CIT PET/CT were not significantly higher than those on I-FP-CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both I-FP-CIT and F-FP-CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of F-FP-CIT PET/CT relative to I-FP-CIT SPECT/CT.

show abstract

Section: Methodsmentioning

confidence: 99%

“…SBR was defined using the following formula: (Mean count of each region – mean count of reference tissue)/mean count of the reference tissue. PCR was defined as the ratio of the mean count in the bilateral putamina to the mean count in the bilateral caudate nuclei (Jeong et al, ).…”

Section: Methodsmentioning

confidence: 99%

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Lee

Kim

Park

et al. 2018

Synapse

View full text Add to dashboard Cite

show abstract

“…Nevertheless, ligand-specific template for presynaptic dopaminergic nerve terminal imaging had been used in several clinical studies without proper validation [ 19 , 23 , 24 ]. One study showed the feasibility of ligand-specific [ 18 F]-FP-CIT PET template and good correlation between the striatal binding and clinical severity scores [ 25 ]. Since only the PD patients were analyzed, they might have missed the unbalanced overestimation of striatal binding between the PD patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Computed Tomography-Guided Methods for Spatial Normalization of Dopamine Transporter Positron Emission Tomography Image

et al. 2015

View full text Add to dashboard Cite

BackgroundSpatial normalization is a prerequisite step for analyzing positron emission tomography (PET) images both by using volume-of-interest (VOI) template and voxel-based analysis. Magnetic resonance (MR) or ligand-specific PET templates are currently used for spatial normalization of PET images. We used computed tomography (CT) images acquired with PET/CT scanner for the spatial normalization for [18F]-N-3-fluoropropyl-2-betacarboxymethoxy-3-beta-(4-iodophenyl) nortropane (FP-CIT) PET images and compared target-to-cerebellar standardized uptake value ratio (SUVR) values with those obtained from MR- or PET-guided spatial normalization method in healthy controls and patients with Parkinson’s disease (PD).MethodsWe included 71 healthy controls and 56 patients with PD who underwent [18F]-FP-CIT PET scans with a PET/CT scanner and T1-weighted MR scans. Spatial normalization of MR images was done with a conventional spatial normalization tool (cvMR) and with DARTEL toolbox (dtMR) in statistical parametric mapping software. The CT images were modified in two ways, skull-stripping (ssCT) and intensity transformation (itCT). We normalized PET images with cvMR-, dtMR-, ssCT-, itCT-, and PET-guided methods by using specific templates for each modality and measured striatal SUVR with a VOI template. The SUVR values measured with FreeSurfer-generated VOIs (FSVOI) overlaid on original PET images were also used as a gold standard for comparison.ResultsThe SUVR values derived from all four structure-guided spatial normalization methods were highly correlated with those measured with FSVOI (P < 0.0001). Putaminal SUVR values were highly effective for discriminating PD patients from controls. However, the PET-guided method excessively overestimated striatal SUVR values in the PD patients by more than 30% in caudate and putamen, and thereby spoiled the linearity between the striatal SUVR values in all subjects and showed lower disease discrimination ability. Two CT-guided methods showed comparable capability with the MR-guided methods in separating PD patients from controls and showed better correlation between putaminal SUVR values and the parkinsonian motor severity than the PET-guided method.ConclusionCT-guided spatial normalization methods provided reliable striatal SUVR values comparable to those obtained with MR-guided methods. CT-guided methods can be useful for analyzing dopamine transporter PET images when MR images are unavailable.

show abstract

“…Moreover, objective image quantification using SPAM has been widely studied in PET data such as 18 F-FP-CIT PET for dopamine transporter imaging [18,19]. Although SPAMbased quantification provided the objective parameters, the previous methods were descriptive and did not preserve anatomical information [8,10].…”

Section: Discussionmentioning

confidence: 99%

Parametric Cerebrovascular Reserve Images Using Acetazolamide 99mTc-HMPAO SPECT: A Feasibility Study of Quantitative Assessment

Choi

Yoo

Cheon

et al. 2013

Nucl Med Mol Imaging

Self Cite

View full text Add to dashboard Cite

Purpose Basal/acetazolamide stress 99m Tc-HMPAO singlephoton emission computed tomography (SPECT) has been widely used for evaluation of hemodynamics; however, qualitative and subjective visual assessment of cerebrovascular reserve (CVR) has been performed in clinical settings. The aim of this study was to generate parametric CVR images and evaluate its feasibility of quantification. Methods Basal/acetazolamide stress 99m Tc-HMPAO SPECT data from 17 patients who underwent bypass surgery or percutaneous transluminal angioplasty were used. Spatial normalization was performed and parametric CVR images were generated using relative CVR (rCVR) of each voxel proportional to CVR of the whole brain. Binary parametric maps to show area of relatively reduced CVR were generated also using threshold of rCVR < 90 %. We calculated rCVR of internal carotid artery (ICA) using the parametric CVR images and probabilistic maps for ICA territory. Pre-and postprocedural parametric CVR images were obtained and quantitative rCVRs were compared. The rCVRs were evaluated according to visual grades for regional decreased CVR. Results Postprocedural rCVR obtained from parametric CVR images increased significantly from preprocedural rCVR. The rCVR was significantly correlated with visual grades of reduced CVR for each side of ICA territories.Conclusions We generated parametric CVR images for basal/acetazolamide stress 99m Tc-HMPAO SPECT. As a quantitative measurement, rCVR obtained from the parametric image was feasibly assessed hemodynamic abnormalities with preserved anatomical information.

show abstract

Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson’s Disease

Cited by 15 publications

References 21 publications

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Feasibility of Computed Tomography-Guided Methods for Spatial Normalization of Dopamine Transporter Positron Emission Tomography Image

Parametric Cerebrovascular Reserve Images Using Acetazolamide 99mTc-HMPAO SPECT: A Feasibility Study of Quantitative Assessment

Contact Info

Product

Resources

About

Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson’s Disease

Cited by 15 publications

References 21 publications

Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Feasibility of Computed Tomography-Guided Methods for Spatial Normalization of Dopamine Transporter Positron Emission Tomography Image

Parametric Cerebrovascular Reserve Images Using Acetazolamide 99mTc-HMPAO SPECT: A Feasibility Study of Quantitative Assessment

Contact Info

Product

Resources

About

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study