2019
DOI: 10.4155/bio-2018-0295
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Abstract: To develop a bioassay for estimation of sodium, potassium and creatinine in dried urine strips and comparing with their respective concentration in liquid urine samples. Materials & methods: Urine was collected on filter paper strips, dried at room temperature and, eluted for estimation of sodium, potassium by indirect ion selective electrode method and creatinine by Jaffé method. Result: This bioassay was validated based on the US FDA guidelines for bioanalytical method validation and was linear, sensitive, a… Show more

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Cited by 5 publications
(5 citation statements)
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“…Conversely, measurement of organic acids in spot dried urine samples using filter paper has already been well-validated as a technique for screening neonates for metabolic disorders [ 15 , 23 , 24 ] and for screening for neuroblastoma [ 25 ] with similar recoveries obtained from liquid and dried urine. Dried urine has also been used to measure other urine analytes of interest, such as sodium and potassium, with similarly high levels of stability [ 26 ]. As with others who used either filter paper or cotton swabs [ 27 ], we found that dried urine results are in agreement with liquid urine results, reduced the burden on patients, and had good stability over time [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, measurement of organic acids in spot dried urine samples using filter paper has already been well-validated as a technique for screening neonates for metabolic disorders [ 15 , 23 , 24 ] and for screening for neuroblastoma [ 25 ] with similar recoveries obtained from liquid and dried urine. Dried urine has also been used to measure other urine analytes of interest, such as sodium and potassium, with similarly high levels of stability [ 26 ]. As with others who used either filter paper or cotton swabs [ 27 ], we found that dried urine results are in agreement with liquid urine results, reduced the burden on patients, and had good stability over time [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, measurement of organic acids in spot dried urine samples using lter paper has already been well-validated as a technique for screening neonates for metabolic disorders 16,59,60 and for screening for neuroblastoma 61 with similar recoveries obtained from liquid and dried urine. Dried urine has also been used to measure other urine analytes of interest, such as sodium and potassium, with similarly high levels of stability 62 . As with others who used either lter paper or cotton swabs 63 , we found that dried urine results are in agreement with liquid urine results, reduced the burden on patients, and had good stability over time 12 .…”
Section: Discussionmentioning
confidence: 99%
“…As a result, the effective treatment period is curtailed, leading to serious lesions and a significant deterioration in quality of life [104]. However, recent research has shown that lab-on-paper platforms provide a feasible means of detecting early-stage kidney disease by evaluating the concentrations of creatinine (Cre) and albumin (Alb) [105][106][107][108][109][110][111], micro-albumin and protein [112][113][114][115][116], and uric acid [117][118][119][120][121][122][123] in urine samples.…”
Section: Creatinine Albumin Protein and Uric Acid Analysismentioning
confidence: 99%
“…An excess quantity of creatinine (Cre) in the urine is a reliable indicator of early-stage kidney disease [105]. Thus, in recent years, various lab-on-paper devices have been proposed for Cre detection in urine samples [106,107]. For instance, Sununta et al [106] demonstrated a colorimetric lab-on-paper device based on the Jaffé reaction of Cre with picric acid under alkaline conditions.…”
Section: Creatinine Albumin Protein and Uric Acid Analysismentioning
confidence: 99%
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