Feasibility of intraoperative electron beam radiation therapy in the treatment of locally advanced pediatric malignancies

Nag, Subir; Retter, Edna; Martı́nez-Monge, Rafael; Bauer, Cary B.; Klopfenstein, Kathryn J.; Ruymann, Frederick B.

doi:10.1002/(sici)1096-911x(199905)32:5<382::aid-mpo13>3.0.co;2-x

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…IOHDR and IOERT have been used in pediatric patients (5)(6)(7). However, high-dose (≥15 Gy) IOERT has been associated with clinically significant toxicity in late-reacting tissues such as vessels and nerves present in the surgical bed (8).…”

Section: Introductionmentioning

confidence: 99%

Feasibility report of conservative surgery, perioperative high-dose-rate brachytherapy (PHDRB), and low-to-moderate dose external beam radiation therapy (EBRT) in pediatric sarcomas

et al. 2004

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Purpose: This study was undertaken to determine the feasibility of perioperative highdose-rate brachytherapy (PHDRB) as an accelerated boost in patients with pediatric sarcomas. Methods and materials:Five pediatric patients (ages 7-16) with soft tissue sarcomas (STS) or soft tissue recurrences of previously treated osteosarcomas were treated with surgical resection and PHDRB (16-24 Gy) for R0-R1 resections. Patients with STS and osteosarcomas received 27 Gy and 45 Gy of EBRT postoperatively.Results: After a median follow-up of 27 months (range, 12-50) all the patients remain locally controlled. Only 1 patient developed regrowth of pulmonary metastases and died of distant disease at 16 months. Conclusions:The use of PHDRB is safe in the short-term in this pediatric population. Only 1 patient suffered a partial wound dehiscence that may not be entirely related to PHDRB. Patients withrecurrent osteosarcomas canbe treatedinafashion similartotheir adultsoft tissuecounterpartsand avoid limb amputation. Younger patients with STS may achieve local control and prevent growth retardation with a combination of PHDRB and moderate doses of EBRT.

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Section: Introductionmentioning

confidence: 99%

Feasibility report of conservative surgery, perioperative high-dose-rate brachytherapy (PHDRB), and low-to-moderate dose external beam radiation therapy (EBRT) in pediatric sarcomas

et al. 2004

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Intraoperative electron beam treatment for pediatric malignancies: The Ohio State University experience

Nag¹,

Tippin²,

Smith³

et al. 2003

Med. Pediatr. Oncol.

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A boost dose of IOERT allows for reduction in the dose of EBRT, thereby limiting growth-related morbidity without compromising local control or disease-free survival. Except for Wilms tumors, which achieved 100% local control and disease-free survival, adjuvant EBRT is necessary for successful local control and survival in children with soft tissue sarcomas. Based on this study and others, intraoperative irradiation should be considered for inclusion in prospective, multi-institutional trials designed to treat localized malignancies in young children.

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Intraoperative radiation therapy

Meiriño

Orecchia

2006

Critical Reviews in Oncology/Hematology

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Feasibility of intraoperative electron beam radiation therapy in the treatment of locally advanced pediatric malignancies

Cited by 6 publications

References 7 publications

Feasibility report of conservative surgery, perioperative high-dose-rate brachytherapy (PHDRB), and low-to-moderate dose external beam radiation therapy (EBRT) in pediatric sarcomas

Feasibility report of conservative surgery, perioperative high-dose-rate brachytherapy (PHDRB), and low-to-moderate dose external beam radiation therapy (EBRT) in pediatric sarcomas

Intraoperative electron beam treatment for pediatric malignancies: The Ohio State University experience

Intraoperative radiation therapy

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