Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression

Golestani, Reza; Mirfeizi, Leila; Zeebregts, Clark J.; Westra, Johanna; Haas, Hans J. de; Glaudemans, Andor W J M; Koole, Michel; Luurtsema, Gert; Tio, René A.; Dierckx, Rudi; Boersma, Hendrikus H.; Elsinga, Philip H.; Slart, Riemer H. J. A.

doi:10.1007/s12350-014-0061-8

Cited by 36 publications

(25 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These processes have become targets of various molecular imaging techniques, as they potentially allow non-invasive risk stratification of individual patients with carotid artery stenosis. 9,10 Recently, several studies have shown the feasibility of 18 F-sodium fluoride ( 18 F-NaF) positron emission tomography (PET) for imaging of atherosclerotic plaques. 11-13 18 F-NaF predominantly binds to areas of microcalcification within the plaque.…”

Section: Introductionmentioning

confidence: 99%

18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

Hop

Boer

Reijrink

et al. 2019

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Background 18 F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18 F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18 F-NaF uptake with calcification visualized on microcomputed tomography (microCT). Methods Carotid plaques from stroke patients undergoing surgery were incubated in 18 F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18 F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18 F-NaF PET volume of interest (VOI) was compared with CT calcification VOI. Results 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18 F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18 F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18 F-NaF PET VOI showed calcification on CT. Conclusions 18 F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18 F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development. Electronic supplementary material The online version of this article (10.1007/s12350-018-1325-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

Hop

Boer

Reijrink

et al. 2019

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

show abstract

“…The majority have been identified from oncology where angiogenesis and hypoxia can help identify areas of rapidly growing tumours. Translating these tracers to CV uses will take time and effort, but efforts are ongoing 63. The emergence of PET-MRI may provide a suitable test bed for these tracers where the combination of tissue characterisation from MRI and molecular imaging from PET promises much 64 65…”

Section: Molecularmentioning

confidence: 99%

State of the art in nuclear cardiology

Sabharwal

2016

Heart

View full text Add to dashboard Cite

“…To detect integrin α v β 3 , several probes such as 18 F-galacto-RGD [20] and 18 F-RGD-k5 [21] have been developed on the basis of arginyl-glycyl-aspartic acid (RGD)-tripeptide sequence which is implicated in cellular attachment via integrin. Laitinen et al [20] showed that areas with high 18 F-galacto-RGD uptake levels colocalized with macrophage-rich areas in atherosclerotic plaques of ApoE -/-mice.…”

Section: Pet/spect Probes For Imaging Inflammatory Cellsmentioning

confidence: 99%

Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging

Shimizu

Kuge

2016

Nucl Med Mol Imaging

View full text Add to dashboard Cite

The rupture of vulnerable atherosclerotic plaques and subsequent thrombus formation are the major causes of myocardial and cerebral infarction. Accordingly, the detection of vulnerable plaques is important for risk stratification and to provide appropriate treatment. Inflammation imaging using 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 F-FDG) has been most extensively studied for detecting vulnerable atherosclerotic plaques. It is of great importance to develop PET/SPECT probes capable of specifically visualizing the biological molecules involved in atherosclerotic plaque formation and/or progression. In this article, we review recent advances in the development of PET/SPECT probes for visualizing atherosclerotic plaques and their application to therapy monitoring, mainly focusing on experimental studies.

show abstract

Feasibility of [18F]-RGD for ex vivo imaging of atherosclerosis in detection of αvβ3 integrin expression

Abstract: This study showed the feasibility of integrin imaging by determination of αvβ3 integrin expression in human atherosclerotic plaques.

Cited by 36 publications

References 27 publications

18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

State of the art in nuclear cardiology

Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging

Contact Info

Product

Resources

About