Feasibility and Accuracy of Menstrual Blood Testing for High-risk Human Papillomavirus Detection With Capture Sequencing

Abstract

This cohort study compares high-risk human papillomavirus (HPV) detection using menstrual blood testing with capture sequencing vs cervical HPV testing.

Diagnostic accuracy of menstrual blood for human papillomavirus detection in cervical cancer screening: a systematic review

“…We identified a total of five studies that met the inclusion criteria of the review [18][19][20][21][22]. The primary aim of these studies was HPV detection using menstrual blood [18][19][20][21][22]; furthermore, few studies also evaluated the prognostic significance of the test [19,21]. All the studies were conducted in Asian countries including China, Republic of Korea and India.…”

“…All the studies were conducted in Asian countries including China, Republic of Korea and India. Most of the studies were conducted in a hospital setting such as university hospitals or local clinics [19][20][21][22] except one which was at population level [18].…”

“…Of these five studies, four studies included women who had a pathological diagnosis of premalignant cervical lesions or positive with HR-HPV infection on cervical sample [19][20][21][22]; whereas one study was conducted in a previously unscreened population [18]. The number of participants ranged from 19 to 558 among these studies.…”

“…The number of participants ranged from 19 to 558 among these studies. Women were asked to provide used menstrual pads in all of the studies [18][19][20][21][22]; however, only one study specified the use of commercially available menstrual pads [22]. A study by Budukh et al [18] was done on menstrual pads as well as menstrual cloth as this is a common menstrual hygiene practice in the rural Indian population.…”

“…The study by Lee et al [20] used a sanitary napkin with filter attached. Women were asked to provide used sanitary napkins or menstrual pad/cloth in zip-lock plastic bags in all the studies [18][19][20][21][22].…”