Fe/ABTS/PVP nanocomplexes with dual GSH-depleting for photothermal-reinforced catalytic bacterial killing

Ban, Chengyang; Shi, Hanzhu; Ding, Qi; Wu, Bin; Xia, Ru; Qian, Jiasheng; Cao, Ming

doi:10.1016/j.colcom.2023.100705

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…[41] Therefore, it is urgent and necessary to reduce the GSH level at the bacterial infection site. [42] Xiao et al synthesized a novel chemodynamic agent (PDA/Fe 3 O 4 ) by modifying polydopamine (PDA) with ultrasmall Fe 3 O 4 (Figure 3B). [43] This chemodynamic agent could consume the GSH overexpressed at the infection site to disrupt cellular redox homeostasis, while PDA/Fe 3 O 4 with H 2 O 2 selfsupplying capability could improve the production of •OH, which enhances the efficacy of CDT in wound disinfection.…”

Section:  Inhibition Of Gsh Overexpressionmentioning

confidence: 99%

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Zhang,

Guo,

Liu

et al. 2023

Exploration

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The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue to persist. Currently, antibiotic therapy remains the primary approach for tackling bacterial infections. However, the escalating rates of drug resistance coupled with the lag in the development of novel drugs have led to diminishing effectiveness of conventional treatments. Therefore, the development of nonantibiotic‐dependent therapeutic strategies has become imperative to impede the rise of bacterial resistance. The emergence of chemodynamic therapy (CDT) has opened up a new possibility due to the CDT can convert H2O2 into •OH via Fenton/Fenton‐like reaction for drug‐resistant bacterial treatment. However, the efficacy of CDT is limited by a variety of practical factors. To overcome this limitation, the sterilization efficiency of CDT can be enhanced by introducing the therapeutics with inherent antimicrobial capability. In addition, researchers have explored CDT‐based combined therapies to augment its antimicrobial effects and mitigate its potential toxic side effects toward normal tissues. This review examines the research progress of CDT in the antimicrobial field, explores various strategies to enhance CDT efficacy and presents the synergistic effects of CDT in combination with other modalities. And last, the current challenges faced by CDT and the future research directions are discussed.

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Section:  Inhibition Of Gsh Overexpressionmentioning

confidence: 99%

“…[ 41 ] Therefore, it is urgent and necessary to reduce the GSH level at the bacterial infection site. [ 42 ] Xiao et al. synthesized a novel chemodynamic agent (PDA/Fe 3 O 4 ) by modifying polydopamine (PDA) with ultrasmall Fe 3 O 4 (Figure 3B).…”

Section: Ways To Improve the Efficacy Of Cdtmentioning

confidence: 99%

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Zhang,

Guo,

Liu

et al. 2023

Exploration

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“…Fe 3 O 4 nanoparticles have attracted extensive attention in bone transplantation due to their excellent biocompatibility and safety [10,11]. It is known that Fe 2+ /Fe 3+ of Fe 3 O 4 can participate in the Fenton reaction, which decomposes hydrogen peroxide (H 2 O 2 ) into highly toxic hydroxyl radical (•OH), which is the most toxic reactive oxygen species (ROS) with high broad-spectrum antibacterial activity [12][13][14][15]. The specific reaction formula is as follows: (1) Fe 3+ + H 2 O 2 → Fe 2+ + OOH − + H + ; (2) Fe 2+ + H 2 O 2 → Fe 3+ + OH − + •OH.…”

Section: Introductionmentioning

confidence: 99%

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

Shuai,

Shi,

Yang

et al. 2023

Int. J. Extrem. Manuf.

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Highlights High-energy ball milling was proposed to construct oxygen vacancy defects. Scaffold with individualized shape and porous structure was fabricated by selective laser sintering. Antibacterial material was used to adsorb H2O2 to the site of bacterial infection. The accumulated H2O2 could amplify the Fenton reaction efficiency to induce more ·OH. The scaffold possessed matched mechanical properties and good biocompatibility.

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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation

Zhang,

Jin,

et al. 2024

Rare Met.

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Fe/ABTS/PVP nanocomplexes with dual GSH-depleting for photothermal-reinforced catalytic bacterial killing

Cited by 7 publications

References 31 publications

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation

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