FDG PET Imaging in Sarcoidosis

Šobić-Šaranović, Dragana; Artiko, Vera; Obradović, Vladimir

doi:10.1053/j.semnuclmed.2013.06.007

Cited by 87 publications

(50 citation statements)

References 56 publications

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“…18 FDG-PET/CT has recently been recognized to be a useful tool for identifying extrathoracic lesions for the purpose of a diagnostic biopsy in cases of sarcoidosis (19). In the current case, 18 FDG-PET/CT showed an unexpected and isolated patchy 18 FDG uptake in the left lower leg without any symptoms.…”

Section: Discussionmentioning

confidence: 73%

Sarcoidosis Presenting Addison's Disease

et al. 2016

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We herein describe a second Japanese case of sarcoidosis presenting Addison's disease. A 52-year-old man was diagnosed with sarcoidosis based on clinical and laboratory findings, including bilateral hilar lymphadenopathy and elevated levels of serum angiotensin-converting enzyme and lysozyme, as well as the presence of noncaseating epithelioid granulomas. The patient also exhibited general fatigue, pigmentation, weight loss, hypotension and hyponatremia, suggestive of chronic adrenocortical insufficiency. An endocrine examination confirmed primary adrenocortical insufficiency. This case suggests the direct involvement of sarcoid granuloma in the adrenal glands.

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Section: Discussionmentioning

confidence: 73%

Sarcoidosis Presenting Addison's Disease

et al. 2016

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“…1 FDG PET has been proposed to play a role in the diagnosis and therapy monitoring of sarcoidosis including cardiac involvement. [2][3][4] However, assessing inflammatory lesions in cardiac sarcoidosis using FDG can be challenging because the FDG accumulates in normal myocardium, a phenomenon known as physiological uptake. 5,6 Methods proposed for inhibiting increased FDG uptake in myocardial physiological cells include heparin, prolonged fasting, and dietary carbohydrate restriction before the scan.…”

Section: Figurementioning

confidence: 99%

18F-FLT PET Imaging in a Patient With Sarcoidosis With Cardiac Involvement

Norikane¹,

Yamamoto²,

Maeda³

et al. 2015

Clinical Nuclear Medicine

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FDG PET has been proposed to play a role in the diagnosis and therapy monitoring of sarcoidosis including cardiac involvement. However, assessing inflammatory lesions in cardiac sarcoidosis using FDG can be challenging because the FDG accumulates in normal myocardium. We report a case of sarcoidosis with cardiac involvement that underwent 3'-deoxy-3'-F-fluorothymidine (FLT) PET. FLT PET images demonstrated increased uptake in the lymph nodes and left ventricle. After immunosuppressive therapy, a follow-up PET scan showed disappearance of FLT uptake in the lymph nodes and left ventricle.

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“…The benefit of using FDG-PET for assessing noncancerous diseases such as osteomyelitis, sarcoidosis, fever of unknown origin, and vasculitis has been well demonstrated. [5–7] Upregulation of glucose transporters in inflammatory cells along with enhanced expression of various inflammatory cytokines enhances FDG uptake in inflammatory states. [8,9] These findings suggest the feasibility of using FDG for assessing various inflammatory joint disorders.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of 18F-fluorodeoxyglucose uptake parameters to differentiate rheumatoid arthritis from other types of arthritis

Bhattarai¹,

Nakajima²,

Yamada³

et al. 2017

Medicine

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We aimed evaluate 18F-fluorodeoxyglucose uptake at major joints for differentiating patients with rheumatoid arthritis (RA) from those with non-RA arthritis using 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET).Eighteen patients with RA (13 women; age, 66.8 ± 13.2 years) and 17 patients with non-RA (6 women; age, 50.8 ± 12.5 years) were included. Twelve joints of each patient were examined: shoulder, elbow, wrist, hip, knee, and ankle on both sides. A visual scoring (VS) system was used; quantitative parameters such as maximum standardized uptake value (SUVmax), metabolic active volume (MAV), and total lesion glycolysis (TLG) were evaluated. Total score and value of each parameter were compared between the RA and non-RA groups.Total VS score (mean, 37.7 ± 9.0 vs 21.9 ± 7.2; P < .0001) and SUVmax (mean, 28.1 ± 8.5 vs 17.9 ± 5.8; P < .001) were significantly higher in the RA group than in the non-RA group. A significant between-group difference was also observed with respect to total MAV (608.3 ± 370.7 vs 176.5 ± 217.8; P < .001) and total TLG (1139.3 ± 759.1 vs 289.5 ± 395.4; P < .001). Receiver operating characteristic curve analysis revealed that total VS had the highest area under curve (.92), with sensitivity and specificity of 88.9% and 76.4%, respectively.Quantitative PET parameters could differentiate RA from non-RA. Total VS score, however, appears to be the best convenient qualitative tool for diagnosing RA.

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FDG PET Imaging in Sarcoidosis

Cited by 87 publications

References 56 publications

Sarcoidosis Presenting Addison's Disease

Sarcoidosis Presenting Addison's Disease

18F-FLT PET Imaging in a Patient With Sarcoidosis With Cardiac Involvement

Diagnostic value of 18F-fluorodeoxyglucose uptake parameters to differentiate rheumatoid arthritis from other types of arthritis

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