Fatty acid intake and erythrocyte fatty acid profile in women with breast, ovarian and cervical cancers

Bannikoppa, Priyanka S.; Dhayanand, J.; Madhukumar, R.; Padmanabhan, Aruna; Bafna, U. D.; Vijayakumar, M.; Devi, K. Uma; Pramod, K.P.R.; Thomas, Tinku; Jayshree, R. S.; Kurpad, Anura V; Mani, Indu

doi:10.1016/j.clnesp.2017.03.001

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…One of the proposed mechanisms involves the vital role of cholesterol in cell membranes, which can influence various signaling pathways [46]. It is known that increased synthesis of fatty acids is one of the most important abnormalities in the metabolism of cancer cells and is necessary for both carcinogenesis and the survival of cancer cells [26,47,48]. To maintain cell proliferation in cancer, it is necessary to enhance lipid metabolism [27,49]; therefore, the lipid level decreases in the group of patients with malignant tumors [50].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Saliva Lipids in Breast and Prostate Cancer by IR Spectroscopy

2021

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We have developed a method for studying the lipid profile of saliva, combining preliminary extraction and IR spectroscopic detection. The case–control study involved patients with a histologically verified diagnosis of breast and prostate cancer and healthy volunteers. The comparison group included patients with non-malignant pathologies of the breast (fibroadenomas) and prostate gland (prostatic intraepithelial neoplasia). Saliva was used as a material for biochemical studies. It has been shown that the lipid profile of saliva depends on gender, and for males it also depends on the age group. In cancer pathologies, the lipid profile changes significantly and also depends on gender and age characteristics. The ratio of 1458/1396 cm−1 for both breast and prostate cancer has a potential diagnostic value. In both cases, this ratio decreases compared to healthy controls. For prostate cancer, the ratio of 2923/2957 cm−1 is also potentially informative, which grows against the background of prostate pathologies. It is noted that, in all cases, changes in the proposed ratios are more pronounced in the early stages of diseases, which increases the relevance of their study in biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Analysis of Saliva Lipids in Breast and Prostate Cancer by IR Spectroscopy

2021

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“…The omega-3 index represents the ratio of EPA + DHA to all other fatty acids incorporated in red blood cell membrane phospholipids, and substantial published research suggests that this measurement is a reliable predictor of cardiovascular event risk (14)(15)(16)(17). In light of this and evidence correlating specific disease states with distinct fatty acid profiles (18)(19)(20), the present study was designed to compare full blood count data, baseline omega-3 index values, and fatty acid profiles of erythrocytes obtained from AAA patients with those of a healthy control cohort as part of an ongoing clinical trial. In addition, the impact of physiologically appropriate n-3 PUFA supplementation on full blood count values, the omega-3 index, and erythrocyte membrane fatty acid composition was examined in a cohort of AAA patients as part of a 12 week randomized double-blind placebo-controlled clinical trial.…”

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n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial

Meital

Windsor

Jewell

et al. 2019

Journal of Lipid Research

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Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0–4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 PUFA (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12 week randomized placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid (LA), and AAA and increased Δ6-desaturase activity and biosynthesis of arachidonic acid (AA) from LA. Omega-3 PUFA supplementation (1.5 g DHA + 0.3 g EPA/day) decreased red blood cell distribution width (14.8 ± 0.4% to 13.8 ± 0.2%; P = 0.003) and levels of pro-inflammatory n-6 PUFAs (AA, 12.46 ± 0.23% to 10.14 ± 0.3%, P < 0.001; adrenic acid, 2.12 ± 0.13% to 1.23 ± 0.09%; P < 0.001). In addition, Δ-4 desaturase activity increased (DHA/docosapentaenoic acid ratio, 1.85 ± 0.14 to 3.93 ± 0.17; P < 0.001) and elongase 2/5 activity decreased (adrenic acid/AA ratio, 0.17 ± 0.01 to 0.12 ± 0.01; P < 0.01) following supplementation. The findings suggest that n-3 PUFAs improve fatty acid profiles and ameliorate factors associated with inflammation in AAA patients.

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Fatty acid intake and erythrocyte fatty acid profile in women with breast, ovarian and cervical cancers

Cited by 4 publications

References 21 publications

Analysis of Saliva Lipids in Breast and Prostate Cancer by IR Spectroscopy

Analysis of Saliva Lipids in Breast and Prostate Cancer by IR Spectroscopy

n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial

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