Fatty acid binding protein regulate antimicrobial function via Toll signaling in Chinese mitten crab

Wang, Shichuang; Zhu, Yunji; Li, Xuejie; Wang, Qun; Li, Jiayao; Li, Weiwei

doi:10.1016/j.fsi.2017.01.036

Cited by 10 publications

(2 citation statements)

References 63 publications

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“…8 A). Furthermore, Wang et al showed that fatty acid binding proteins regulate antimicrobial functions via Toll signaling pathway, 42 providing further evidence for protection of the ocular surface against pathogens by the tear film. In addition, we showed that the upregulation of “antimicrobial humoral response” in the tear proteome positively correlated with both, the genus Agrobacterium and with vitamin B1 synthesis ( Figs.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome

Zysset-Burri

Schlegel

Lincke

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to explore the interplay between the ocular surface microbiome and the tear proteome in humans in order to better understand the pathogenesis of ocular surface-associated diseases. Methods Twenty eyes from 20 participants were included in the study. The ocular surface microbiome was sequenced by whole-metagenome shotgun sequencing using lid and conjunctival swabs. Furthermore, the tear proteome was identified using chromatography tandem mass spectrometry. After compositional and functional profiling of the metagenome and functional characterization of the proteome by gene ontology, association studies between the ocular microbiome and tear proteome were assessed. Results Two hundred twenty-nine taxa were identified with Actinobacteria and Proteobacteria being the most abundant phyla with significantly more Propionibacterium acnes and Staphylococcus epidermidis in lid compared to conjunctival swabs. The lid metagenomes were enriched in genes of the glycolysis lll and adenosine nucleotides de novo and L-isoleucine biosynthesis. Correlations between the phylum Firmicutes and fatty acid metabolism, between the genus Agrobacterium as well as vitamin B1 synthesis and antimicrobial activity, and between biosynthesis of heme, L-arginine, as well as L-citrulline and human vision were detected. Conclusions The ocular surface microbiome was found to be associated with the tear proteome with a role in human immune defense. This study has a potential impact on the development of treatment strategies for ocular surface-associated diseases.

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Section: Discussionmentioning

confidence: 99%

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome

Zysset-Burri

Schlegel

Lincke

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…From these findings, it can be presumed in a generalized layout that the members of FABP superfamily proteins being associated with the nematode hypodermis might act as protectants against microbial pathogenesis, whereas the glycosylated mucins or mucin-like proteins act as facilitators. The FABPs are reportedly involved in innate immunity and antimicrobial responses in other invertebrates ( Cheng et al., 2013 ; Tan et al., 2015 ; Wang et al., 2017 ). But, the mucin-like protein being a basic structural component for cuticular integrity when facilitates the pathogenesis it indicates a co-evolutionary advancement for the obligate bacterium Pasteuria that targets a basic cuticular constituent for its secured parasitic success at the stage of attachment.…”

Section: Nature Of the Cuticle Receptormentioning

confidence: 99%

Exploring the mechanisms of host-specificity of a hyperparasitic bacterium (Pasteuria spp.) with potential to control tropical root-knot nematodes (Meloidogyne spp.): insights from Caenorhabditis elegans

Davies,

Mohan,

Phani

et al. 2023

Front. Cell. Infect. Microbiol.

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Plant-parasitic nematodes are important economic pests of a range of tropical crops. Strategies for managing these pests have relied on a range of approaches, including crop rotation, the utilization of genetic resistance, cultural techniques, and since the 1950’s the use of nematicides. Although nematicides have been hugely successful in controlling nematodes, their toxicity to humans, domestic animals, beneficial organisms, and the environment has raised concerns regarding their use. Alternatives are therefore being sought. The Pasteuria group of bacteria that form endospores has generated much interest among companies wanting to develop microbial biocontrol products. A major challenge in developing these bacteria as biocontrol agents is their host-specificity; one population of the bacterium can attach to and infect one population of plant-parasitic nematode but not another of the same species. Here we will review the mechanism by which infection is initiated with the adhesion of endospores to the nematode cuticle. To understand the genetics of the molecular processes between Pasteuria endospores and the nematode cuticle, the review focuses on the nature of the bacterial adhesins and how they interact with the nematode cuticle receptors by exploiting new insights gained from studies of bacterial infections of Carnorhabditis elegans. A new Velcro-like multiple adhesin model is proposed in which the cuticle surface coat, which has an important role in endospore adhesion, is a complex extracellular matrix containing glycans originating in seam cells. The genes associated with these seam cells appear to have a dual role by retaining some characteristics of stem cells.

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The “normal” ocular microbiome and human eye health

Patel

Cavuoto

2023

Microbiome and the Eye

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Fatty acid binding protein regulate antimicrobial function via Toll signaling in Chinese mitten crab

Cited by 10 publications

References 63 publications

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome

Exploring the mechanisms of host-specificity of a hyperparasitic bacterium (Pasteuria spp.) with potential to control tropical root-knot nematodes (Meloidogyne spp.): insights from Caenorhabditis elegans

The “normal” ocular microbiome and human eye health

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