Fatores associados à coinfecção HIV/sífilis no início da terapia antirretroviral

Simões, Luana Andrade; Mendes, Jullye Campos; Silveira, Micheline Rosa; Costa, André Moura Gomes da; Lula, Mariana Dias; Ceccato, Maria das Graças Braga

doi:10.11606/s1518-8787.2022056003904

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…Tendo como dados mais recentes em 2021, Simões et al (16) , dos 459 indivíduos avaliados, teve uma prevalência de 19,5% de infecções por via sexual, sendo a sífilis a infecção mais frequente.…”

Section: Resultsunclassified

Consequências imunológicas e sintomatológicas decorrentes da infecção do Vírus da Imunodeficiência Humana (HIV)

Silva¹,

Santos²,

Sant’Anna³

2023

Braz. J. Hea. Rev.

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O vírus da Imunodeficiência Humana (HIV) infecta predominantemente as células TCD4+, e a destruição dessas células pode ocorrer pelo efeito citopático do vírus. Adicionalmente, existe um aumento da apoptose dessas células e, por expressarem antígenos virais no nível da membrana, as células podem também ser destruídas por citotoxicidade mediada pela célula TCD8+, fenômeno que também contribui para a redução das células CD4+. Tem como objetivo esclarecer as consequências imunológicas e sintomatológicas decorrentes da infecção pelo HIV, relacionando as características sócio-demográfico dos infectados e o mecanismo de escape do vírus. Foi realizado uma revisão de literatura a respeito sobre as principais alterações imunológicas do vírus, diagnóstico e tratamento, os aspectos sintomatológicos, sinais e sintomas, abordando sobre o perfil sócio-demográfico e as coinfecções que os indivíduos estão susceptíveis a adquirirem. Foi possível observar que através da presente revisão integrativa de literatura da produção científica de alguns autores, o vírus causa diversas alterações imunológicas sendo elas relacionadas a fatores imunológicos, ao diagnóstico e tratamento e no aspecto sintomatológicos.

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Section: Resultsunclassified

Consequências imunológicas e sintomatológicas decorrentes da infecção do Vírus da Imunodeficiência Humana (HIV)

Silva¹,

Santos²,

Sant’Anna³

2023

Braz. J. Hea. Rev.

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“…Tidak terdapat perbedaan manifestasi klinis pada penderita sehat ataupun yang terinfeksi HIV, namun koinsiden sifilis dan HIV dapat mengubah tanda dan gejala serta risiko menjadi stadium tersier. 18 Stadium awal sifilis diawali dengan sifilis primer yang ditandai dengan ulkus, lesi ulserasi berbatas tegas, relatif tidak nyeri, dan berkembang dari papula di tempat kontak kelamin sekitar 10-90 hari setelah paparan. Papula biasanya memiliki diameter 0,5-1,5 cm, setelah 1 minggu papul akan mengalami ulserasi dan menghasilkan ulkus khas sifilis primer.…”

Section: Discussionunclassified

“…Pada sifilis primer dapat juga ditemukan limfadenopati inguinalis unilateral atau bilateral. 18 Infeksi sifilis dapat meningkatkan risiko penularan infeksi HIV sebesar 3 kali lipat karena meningkatnya replikasi virus, pelepasan virus, dan viral load dalam cairan sperma pasien HIV. 19 Koinsiden sifilis pada pasien HIV dapat meningkatkan konsentrasi RNA HIV plasma dan menurunkan jumlah sel T CD4+, sehingga dapat meningkatkan risiko penularan HIV.…”

Section: Discussionunclassified

Risky Behavior of Men who have Sex with Men (MSM) Increases the Risk of HIV and Syphilis Infection

Ida Ayu Cintya Pradnyandari,

Anak Agung Candra Wahyuni,

Putu Dyah Ayu Saraswati

2024

Cermin Dunia Kedokteran

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The incidence of sexually transmitted infections in man who have sex with man (MSM) is increased among human immunodeficiency virus (HIV) patients. HIV and syphilis are two sexually transmitted diseases that frequently interact and modify the symptoms and signs of the disease. A case of a 27-year-old male with generalized multiple erythematous plaques including palms and soles since 4 days ago was reported. The patient has been diagnosed with HIV since 2017. The patient is sexually active with a male sex partner and rarely uses condoms. Diagnosis of syphilis is made based on anamnesis, physical examination, and laboratory tests. The treatment was benzathine penicillin G 2.4 million units in 3 doses. The combination of HIV and syphilis needs longer therapy and requires serological follow-up for up to 24 months.

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“…In addition to the risk of these infections in MSM, various authors have reported extensive heterogeneity in the associated factors. These may include having a higher number of sexual partners, 19 , 20 not using condoms, 19 engaging in receptive anal sex, 21 identifying as homosexual or bisexual, 19 , 22 a history of STIs, 23 alcohol consumption, 21–23 lack of a stable partner, 20 , 21 and educational level. 20 , 24 …”

Section: Introductionmentioning

confidence: 99%

Prevalence of HIV, Treponema pallidum and Their Coinfection in Men Who Have Sex with Men, Medellín-Colombia

Cardona-Arias,

Vidales-Silva,

Ocampo-Ramírez

et al. 2024

HIV

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Introduction In Colombia, HIV and gestational syphilis are notifiable events; however, they are poorly investigated infections in men who have sex with men (MSM). Objective To determine the prevalence of HIV, Treponema pallidum , and their co-infection in MSM treated at a Health Services Provider Institution (HSPI) specialized in infectious diseases from Medellín. Methods Cross-sectional study with 3454 MSM. Prevalence was determined with its 95% confidence interval; associated factors were identified using Fisher’s Exact test, Pearson’s Chi-square, and trend Chi-square. Multivariate adjustment was performed using logistic regression. Analyses were performed using SPSS 29.0. Results The prevalence of HIV was 5.7%, T. pallidum 0.7%, and co-infection 0.6%. The prevalence of HIV was higher in MSM aged between 24–40 years (7.5%), with technical or university studies (10.0%), without health insurance affiliation (12.4%), and those who have had a sexual partner with HIV (36.2%). T. pallidum was higher in MSM without health insurance affiliation (3.4%), who had sexual relations with people diagnosed with an STI (5.9%), and a sexual partner with HIV (12.1%). Co-infection was higher in MSM without health insurance affiliation (2.7%), and those who had a partner with HIV (11.2%). Conclusion Compared with the general Colombian population, MSM have a higher risk of HIV, but are similar to T. pallidum . The identification of the main associated factors in each infection demonstrates the need to prioritize subgroups of MSM that show greater vulnerability to these events. This research demonstrates the urgency of implementing health education strategies in MSM who have a sexual partner with HIV or other STIs. Large gaps were also evident in the magnitude of the three events according to the health insurance affiliation regime, which demonstrates problems of social and health injustice, especially with MSM without health insurance affiliation.

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Fatores associados à coinfecção HIV/sífilis no início da terapia antirretroviral

Cited by 8 publications

References 24 publications

Consequências imunológicas e sintomatológicas decorrentes da infecção do Vírus da Imunodeficiência Humana (HIV)

Consequências imunológicas e sintomatológicas decorrentes da infecção do Vírus da Imunodeficiência Humana (HIV)

Risky Behavior of Men who have Sex with Men (MSM) Increases the Risk of HIV and Syphilis Infection

Prevalence of HIV, Treponema pallidum and Their Coinfection in Men Who Have Sex with Men, Medellín-Colombia

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