Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization

Turnbull, Travis Lee; Baumann, Andrew P.; Roeder, Ryan K.

doi:10.1016/j.jbiomech.2014.06.022

Cited by 34 publications

(27 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During continuous vigorous activity, however, microcracks will grow and even develop to the macro scale, leading to a stress fracture [9, 21, 30]. Our study supported these results.…”

Section: Discussionsupporting

confidence: 85%

Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna

Han

et al. 2017

BioMed Eng OnLine

View full text Add to dashboard Cite

BackgroundFatigue damage of the long bones is prevalent in running athletes and military recruits due to vigorous mid- and long-term physical activity. The current study attempted to know the features of bony athletic fatigue damage and to explore the mechanism of fatigue damage repair through bone targeted remodeling process.MethodsRight ulnae of the Wistar rats were fatigue loaded on an INSTRON 5865 to construct the athletic fatigue damage model, and several time points (i.e. experimental days: 0, 7, 13 and 19) were selected to simulate physiological status, preliminary, mid-term and perennial stage during continuous high-intensive training, respectively. The multi-level responses of rat ulnae under the athletic fatigue loading, including cellular protein expression, micro damage or micro-crack and macro mechanical properties, were tested and statistically analyzed.ResultsWistar rats, subjected to the athletic fatigue loading protocol, experienced a decrease of ulna fatigue mechanical properties and an active bone resorption of the loaded ulnae in the early stage, whereafter, a hyperactive bone formation and significant improvements of ulnae fatigue mechanical properties were detected. However, a deterioration of quasi-static mechanical properties in the subsequent period implied limitations of bone remodeling to maintain the bearing capacity of bone during long-term strenuous exercise.ConclusionsIn summary, after athletic fatigue loading, bone targeted remodeling is activated and proceeds to repair fatigue damage, but only to a certain extent.

show abstract

“…During continuous vigorous activity, however, microcracks will grow and even develop to the macro scale, leading to a stress fracture [9, 21, 30]. Our study supported these results.…”

Section: Discussionsupporting

confidence: 85%

Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna

Han

et al. 2017

BioMed Eng OnLine

View full text Add to dashboard Cite

show abstract

“…Considering this, B.Ar's more precise measure of viable cortex may better represent the impact of microdamage on bone fragility than Ct.Ar . This concern is particularly relevant when viewed in light of evidence showing existing pores as potential stress raisers . Furthermore, in microdamage studies, accounting for intracortical porosity may significantly influence areal density measures of microcracks.…”

Section: Data Collectionmentioning

confidence: 99%

“…Microdamage quantification occurs in different ways from classification by type and location (eg, diffuse versus linear microcracks, lamellar versus interstitial bone, etc. (28,46) ) to assessment in relation to features such as porosity or lacunar density, (47,48) and even measuring the displacement of crack openings. (49) The most common approach is simple counts and measures of linear microcracks and their areal densities.…”

Section: Histomorphometric Variablesmentioning

confidence: 99%

Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Dominguez

Agnew

2019

JBMR Plus

View full text Add to dashboard Cite

Microdamage is a component of bone quality believed to play an integral role in bone health. However, comparability between existing studies is fraught with issues due to highly variable methods of sample preparation and poorly defined quantification criteria. To address these issues, this article has two aims. First, detailed methods for preparation and analysis of linear microcracks in human ribs, specifically addressing troubleshooting issues cited in previous studies, are laid out. Second, new, partially validated criteria are proposed in an effort to reduce subjective differences in microcrack counts and measures, ensuring more comparable results between studies. Revised definitions based on current literature in conjunction with a digital atlas to reduce observer inaccuracy and bias are presented. The goal is to provide a practical methodology for bone biologists and biomechanists to collect and analyze linear microcracks for basic science research. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

show abstract

“…The ageing process makes the interstitial bone tissue stiffer [39,92], which was shown numerically to have a profound effect on the bone fracture mechanics [74,[93][94][95][96][97]. In addition, ageing leads Bone toughness mechanisms at different levels of hierarchy.…”

Section: Bone Toughening Mechanismsmentioning

confidence: 99%

Modelling of bone fracture and strength at different length scales: a review

Sabet¹,

Najafi²,

Hamed³

et al. 2016

Interface Focus.

109

View full text Add to dashboard Cite

In this paper, we review analytical and computational models of bone fracture and strength. Bone fracture is a complex phenomenon due to the composite, inhomogeneous and hierarchical structure of bone. First, we briefly summarize the hierarchical structure of bone, spanning from the nanoscale, sub-microscale, microscale, mesoscale to the macroscale, and discuss experimental observations on failure mechanisms in bone at these scales. Then, we highlight representative analytical and computational models of bone fracture and strength at different length scales and discuss the main findings in the context of experiments. We conclude by summarizing the challenges in modelling of bone fracture and strength and list open topics for scientific exploration. Modelling of bone, accounting for different scales, provides new and needed insights into the fracture and strength of bone, which, in turn, can lead to improved diagnostic tools and treatments of bone diseases such as osteoporosis.

show abstract

Fatigue microcracks that initiate fracture are located near elevated intracortical porosity but not elevated mineralization

Cited by 34 publications

References 33 publications

Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna

Effect of athletic fatigue damage and the associated bone targeted remodeling in the rat ulna

Microdamage as a Bone Quality Component: Practical Guidelines for the Two‐Dimensional Analysis of Linear Microcracks in Human Cortical Bone

Modelling of bone fracture and strength at different length scales: a review

Contact Info

Product

Resources

About