Fatigue and Depression in Disease-Free Breast Cancer Survivors: Prevalence, Correlates, and Association with Quality of Life

Kim, Soo Hyun; Son, Byung Ho; Hwang, Sook Yeon; Han, Wonshik; Yang, Jung Hyun; Lee, Seeyoun; Yun, Young Ho

doi:10.1016/j.jpainsymman.2007.08.012

Cited by 224 publications

(286 citation statements)

References 54 publications

(63 reference statements)

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“…Our findings concurred with studies whereby participant's QoL remained unchanged after undergoing physical activity intervention over a period of time (Segal et al, 2001;Kim et al, 2008). In this trial, line dancing was used as exercise-control group to control for the social-effect of group.…”

Section: Discussionsupporting

confidence: 88%

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The Kuala Lumpur Qigong Trial for Women in the Cancer Survivorship Phase-Efficacy of a Three-Arm RCT to Improve QOL

Loh¹,

Lee²,

Murray³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Qigong is highly favoured among Asian breast cancer survivors for enhancing health. This study examined the hypothesis that quality of life (QoL) in the Qigong group is better than the placebo (aerobic) or usual care group. Materials and Methods: A total of 197 participants were randomly assigned to either the 8-week Kuala Lumpur Qigong Trial or control groups in 2010-2011. Measurement taken at baseline and postintervention included QoL, distress and fatigue. Analysis of covariance (ANCOVA) and Kruskal Wallis were used to examine for differences between groups in the measurements. Results: There were 95 consenting participants in this 8week trial. The adherence rates were 63% for Qigong and 65% for the placebo group. The Qigong group showed significant marginal improvement in Quality of life scores compared to placebo (mean difference=7.3 unit; p=0.036), compared to usual care (mean difference=6.7 unit; p=0.048) on Functional Assessment Cancer Therapy-Breast measure. There were no significant changes between the placebo and usual care groups in fatigue or distress at post intervention (8-week). Conclusions: Cancer survivors who participated in the Qigong intervention showed slightly better QOL. Follow up studies are greatly needed to evaluate which subgroups may best benefit from Qigong. With a steep rise of cancer survivors, there is an urgent need to explore and engage more cultural means of physical activity to fight side effects of treatment and for cancer control in developing countries.

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Section: Discussionsupporting

confidence: 88%

“…Some studies had found that fatigue may persist even years after active treatment (Meeske et al, 2007;Kim et al, 2008). In this study, the baseline fatigue scores were relatively higher compared to studies that used the same outcome measure.…”

Section: Discussionmentioning

confidence: 57%

The Kuala Lumpur Qigong Trial for Women in the Cancer Survivorship Phase-Efficacy of a Three-Arm RCT to Improve QOL

Loh¹,

Lee²,

Murray³

2014

Asian Pacific Journal of Cancer Prevention

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“…The point prevalence of depression among this group of breast cancer survivors is much lower than reported in some previous studies [20], but at 9%, it is in line with rates in primary care settings of 5-10% [21] and rates reported in some studies of cancer outpatients [3,22]. There is some evidence that after an initial rise, the prevalence of depression decreases over time following the diagnosis of breast cancer [1].…”

Section: Discussionsupporting

confidence: 81%

Evaluation of screening instruments for depression and anxiety in breast cancer survivors

Alexander

Palmer

Stone

2009

Breast Cancer Res Treat

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Although cases of anxiety and depression postbreast cancer can be reliably identified using a structured psychiatric interview, such interviews are time consuming for both practitioner and patient and effective screening tools would increase detection rates. The purpose of this study was to evaluate the effectiveness of the Edinburgh Depression Scale (EDS) and the Hospital Anxiety and Depression Scale (HADS) in screening for depression and anxiety in a population of breast cancer survivors. For this purpose, The Structured Clinical Interview for the Diagnostic and Statistical Manual of mental disorders was administered to 200 breast cancer survivors to identify those suffering from an anxiety and/or depressive disorder. All study participants also completed the EDS and the HADS. Using the recommended cut-off score of [12 to screen for depression, the sensitivity and specificity of the EDS were found to be 72 and 90%, respectively. Lowering the cut-off score to [9 resulted in a sensitivity of 94% and a specificity of 78%. At the recommended cut-off score of [10, the HADS had a sensitivity of 50% and a specificity of 97% for depression, and a sensitivity of 71% and a specificity of 86% when screening for anxiety. A HADS total score (HADS-T) of [13 and an EDS of [9 had sensitivities of 96 and 91% and specificities of 74 and 84%, respectively, in screening for anxiety and/or depression. In conclusion, the study demonstrated that both the EDS and HADS can be used reliably as screening tests for anxiety and depression in this cohort. In both cases, a lower cut-off score than normally recommended delivers optimal screening properties.

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“…Moreover, previous studies have confirmed that breast cancer survivors with increased fatigue rated their quality of life at a lower level [12][13][14]16 . On the other hand, assessing fatigue in cancer survivors is a challenge since fatigue is also a common complaint with some level of fatigue reported by the general population 17,18 .…”

Section: Introductionmentioning

confidence: 79%

“…Many studies suggest that fatigue is a common problem experienced by female survivors of breast cancer 6,[9][10][11][12][13][14][15] . Moreover, previous studies have confirmed that breast cancer survivors with increased fatigue rated their quality of life at a lower level [12][13][14]16 .…”

Section: Introductionmentioning

confidence: 99%

Fatigue and quality of life in breast cancer survivors: a comparative study

Kluthcovsky¹,

Urbanetz²

2015

Rev. Bras. Ginecol. Obstet.

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PURPOSE: To assess fatigue and quality of life in disease-free breast cancer survivors in relation to a sample of age-matched women with no cancer history and to explore the relationship between fatigue and quality of life. METHODS: A cross-sectional study was conducted in a sample of 202 consecutive disease-free Brazilian breast cancer survivors, all of whom had completed treatment, treated at 2 large hospitals. The patients were compared to age-matched women with no cancer history attending a primary health care center. The Piper Fatigue Scale-Revised and the World Health Organization Quality of Life Instrument (WHOQOL-BREF) were used to measure the fatigue and quality of life, respectively. Socio-demographic and clinical variables were also obtained. The χ 2 test, generalized linear model, and Spearman correlation coefficient were used for statistical purposes. The adopted level of significance was 5%. RESULTS: Breast cancer survivors experienced significantly greater total and subscale fatigue scores than comparison group (all p-values<0.05). In addition, survivors reported a poorer quality of life in physical (p=0.002), psychological (p=0.03), and social relationships (p=0.03) domains than comparison group. No difference was found for the environmental domain (p=0.08) for both groups. For survivors of breast cancer and for comparison group, the total and subscale fatigue scores were related to lower quality of life (all p-values<0.01). CONCLUSION: The findings of this study highlight the importance of assessing fatigue and quality of life in breast cancer survivors. ResumoOBJETIVO: Avaliar a fadiga e a qualidade de vida de sobreviventes de câncer de mama, livres da doença, em relação a uma amostra de mulheres da mesma idade, sem histórico de câncer, e explorar a relação entre fadiga e qualidade de vida. MÉTODOS: Estudo transversal realizado com uma amostra consecutiva de 202 pacientes brasileiras, sobreviventes de câncer de mama e livres da doença, que haviam completado o tratamento em 2 grandes hospitais. As pacientes foram comparadas com mulheres da mesma idade, sem história de câncer, acompanhadas em uma Unidade Básica de Saúde. A Escala de Fadiga de Piper-Revisada e o World Health Organization Quality of Life Instrument (WHOQOL-BREF) foram usados para avaliar a fadiga e a qualidade de vida, respectivamente. Dados sociodemográficos e clínicos também foram obtidos. O teste do χ 2 , modelo linear generalizado e coeficiente de correlação de Spearman foram utilizados para fins estatísticos. Foi adotado o nível de significância de 5%. RESULTADOS: As sobreviventes de câncer de mama apresentaram significativamente maiores escores de fadiga total e das subescalas do que o grupo controle (todos os valores de p<0,05). Além disso, as sobreviventes relataram pior qualidade de vida nos domínios físico (p=0,002), psicológico (p=0,03) e relações sociais (p=0,03) do que o grupo controle. Nenhuma diferença foi encontrada para o domínio ambiental (p=0,08) entre os 2 grupos. Para as sobreviventes de câncer de mama...

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Fatigue and Depression in Disease-Free Breast Cancer Survivors: Prevalence, Correlates, and Association with Quality of Life

Cited by 224 publications

References 54 publications

The Kuala Lumpur Qigong Trial for Women in the Cancer Survivorship Phase-Efficacy of a Three-Arm RCT to Improve QOL

The Kuala Lumpur Qigong Trial for Women in the Cancer Survivorship Phase-Efficacy of a Three-Arm RCT to Improve QOL

Evaluation of screening instruments for depression and anxiety in breast cancer survivors

Fatigue and quality of life in breast cancer survivors: a comparative study

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