Fate of arsenic in living systems: Implications for sustainable and safe food chains

Rehman, Muneeb U.; Khan, Rehan; Khan, Andleeb; Qamar, Wajhul; Arafah, Azher; Ahmad, Anas; Ahmad, Ajaz; Akhter, Rehana; Rinklebe, Jörg; Ahmad, Parvaiz

doi:10.1016/j.jhazmat.2021.126050

Cited by 92 publications

(35 citation statements)

References 145 publications

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“…Industrial, agricultural, transportation, and other daily activities all over the world increased the levels of pollution, particularly heavy metals in soil, water, and air environments [1,2]. The presence of heavy metals due to pollution led to harmful impacts on human health and the eco-system [3].…”

Section: Introductionmentioning

confidence: 99%

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

et al. 2022

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Heavy metals intoxication causes several health problems that necessitate finding new protective and therapeutic approaches. This study aimed to evaluate the impact of Musa sp. leaves extract (MLE) on hepato-renal toxicities induced by cadmium (Cd) in male mice. The phytochemical screening, metal chelating activity (MCA), and the median lethal dose (LD50) of MLE were determined. Fifty CD-1 male mice were used and intraperitoneally (i.p.) injected with MLE (1000 to 5000 mg/kg b.wt) for MLE LD50 determination. Another 50 mice were used for evaluating the effect of MLE on Cd toxicity. Blood samples were collected for hematological, liver, and kidney functions assessments. Liver tissue homogenates were used for determination of oxidant/antioxidant parameters. Liver and kidney tissues were harvested for histopathological and molecular investigations. MLE showed potent in vitro antioxidant activities. The MCA and LD50 of the MLE were 75 µg/mL and 3000 mg/kg b.wt, respectively. MLE showed beneficial therapeutic activity against hepato-renal toxicities in Cd-intoxicated mice, evidenced by improving the hematological, biochemical, histopathological, and molecular alterations.

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Section: Introductionmentioning

confidence: 99%

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

et al. 2022

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“…Human exposure to As can take place via ingestion (oral), dermal contact, inhalation, and even parenteral routes [54]. The main causes of As ingestion by humans is to drink water contaminated with this metalloid or to eat certain contaminated foods as fishes or crops (especially As hyperaccumulator plants, as rice) that, in most cases, were irrigated with groundwater containing As [55][56][57]. It is estimated that nearly 108 countries are affected by As contamination in groundwater, with concentrations beyond the recommended maximum permitted amounts by the World Health Organization [55].…”

Section: Anthropogenic As a Global Environmental Problem With Health Risksmentioning

confidence: 99%

“…These primary producers and consumers are preyed on by other marine animals, causing As to be transformed to organoarsenic species and biomagnified through the food chain. Arsenobetaine (AB) is the predominant organoarsenic species found in most finfish and shellfish, typically accounting for more than 90% of the total As [14,57,62]. Fortunately, the most toxic inorganic As species are accumulated in greater quantity at lower trophic levels in the food chain.…”

Section: Anthropogenic As a Global Environmental Problem With Health Risksmentioning

confidence: 99%

“…Recent studies reveal that benthic habits were an important factor for As biomagnification in marine ecosystems [56]. Little is known about As bioaccumulation in organisms and biomagnification in freshwater ecosystems and the results are disperse and controversial [57]. Experimental data from As contaminated lakes showed an enhanced trophic transfer of As through the base of the aquatic food web in weakly stratified lakes.…”

Section: Anthropogenic As a Global Environmental Problem With Health Risksmentioning

confidence: 99%

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Interactions with Arsenic: Mechanisms of Toxicity and Cellular Resistance in Eukaryotic Microorganisms

Francisco

Martín‐González

Rodríguez-Martín

et al. 2021

IJERPH

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Arsenic (As) is quite an abundant metalloid, with ancient origin and ubiquitous distribution, which represents a severe environmental risk and a global problem for public health. Microbial exposure to As compounds in the environment has happened since the beginning of time. Selective pressure has induced the evolution of various genetic systems conferring useful capacities in many microorganisms to detoxify and even use arsenic, as an energy source. This review summarizes the microbial impact of the As biogeochemical cycle. Moreover, the poorly known adverse effects of this element on eukaryotic microbes, as well as the As uptake and detoxification mechanisms developed by yeast and protists, are discussed. Finally, an outlook of As microbial remediation makes evident the knowledge gaps and the necessity of new approaches to mitigate this environmental challenge.

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“…Arsenic (As), a ubiquitous potentially noxious metalloid, exists as inorganic or organic forms, with arsenate (As V ) and arsenite (As III ) as the primary inorganic forms, in the environment (Rahaman et al, 2021 ; Rehman et al, 2021 ). It is becoming a severe disquiet due to its toxicity in humans, animals, and plants and hence regarded as a priority contaminant (Li et al, 2018 ; Rahaman et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Oligochitosan fortifies antioxidative and photosynthetic metabolism and enhances secondary metabolite accumulation in arsenic-stressed peppermint

Ahmad

Dar²,

Khan³

et al. 2022

Front. Plant Sci.

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The current study was designed to investigate whether application of irradiated chitosan (ICn), a recently established plant growth promoter, can prove effective in alleviating arsenic (As) stress in peppermint, a medicinally important plant. This study investigated how foliar application of ICn alleviated As toxicity in peppermint (Mentha piperita L.). Peppermint plants were treated with ICn (80 mg L−1) alone or in combination with As (10, 20, or 40 mg kg−1 of soil, as Na2HAsO4·7H2O) 40 days after transplantation (DAT), and effects on the growth, photosynthesis, and antioxidants were assessed at 150 DAT as stress severely decreases plant growth, affects photosynthesis, and alters enzymatic (ascorbate peroxidase, superoxide dismutase) and non-enzymatic (glutathione) antioxidants. When applied at 40 mg kg−1, ICn significantly decreased the content of essential oil (EO) and total phenols in peppermint by 13.8 and 16.0%, respectively, and decreased phenylalanine ammonia lyase (PAL) and deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) activities by 12.8 and 14.6%, respectively. Application of ICn mitigated the disadvantageous effects caused by As toxicity in peppermint by enhancing activities of antioxidative enzymes and photosynthesis and increased accretion of secondary metabolism products (EOs and phenols). An enhancement of total phenols (increased by 17.3%) and EOs (36.4%) is endorsed to ICn-stimulated enhancement in the activities of PAL and DXR (65.9 and 28.9%, respectively) in comparison to the control. To conclude, this study demonstrated that foliar application of ICn (80 mgL−1) effectively promoted the growth and physiology of peppermint and eliminated As-induced toxicity to achieve high production of EO-containing crops grown in metal-contaminated soils.

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Fate of arsenic in living systems: Implications for sustainable and safe food chains

Cited by 92 publications

References 145 publications

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

Musa sp. Leaves Extract Ameliorates the Hepato-Renal Toxicities Induced by Cadmium in Mice

Interactions with Arsenic: Mechanisms of Toxicity and Cellular Resistance in Eukaryotic Microorganisms

Oligochitosan fortifies antioxidative and photosynthetic metabolism and enhances secondary metabolite accumulation in arsenic-stressed peppermint

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