Fatal melanoma arising in a zosteriform speckled lentiginous nevus

Bolognia, J. L.

doi:10.1001/archderm.127.8.1240b

Cited by 8 publications

(4 citation statements)

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“…Three patients presenting melanoma arising in a speckled zosteriform lentiginous nevus developed fatal metastatic disease [10,11,14], Therefore nevus spilus can be considered as a possible rare precursor lesion of malignant melanoma [3,[11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Spitz’s Nevus Arising on a Nevus spilus

Hofmann‐Wellenhof¹,

Soyer²,

Smolle³

et al. 1994

Dermatology

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Section: Discussionmentioning

confidence: 99%

Spitz’s Nevus Arising on a Nevus spilus

Hofmann‐Wellenhof¹,

Soyer²,

Smolle³

et al. 1994

Dermatology

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“…On the other hand, malignant degeneration seems to occur less frequently when compared to macular SLN. There are only 6 reports of malignant melanoma originating from papular SLN [1, 16, 29,64,65,66]. Four of these patients were women.…”

Section: Papular Slnmentioning

confidence: 99%

“…In some cases, however, large skin segments may be involved in a checkerboard pattern [12,13,14]. Occasionally, the arrangement has erroneously been called ‘zosteriform’ [4,15,16,17], although the distribution is definitely not dermatomal. Sometimes, SLN may be part of complex birth defects such as phacomatosis pigmentovascularis [18,19,20,21,22,23,24,25], phacomatosis pigmentokeratotica [26,27,28,29,30,31,32], or SLN syndrome [33].…”

Section: Introductionmentioning

confidence: 99%

Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

Cruz

Happle²

2006

Dermatology

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Background: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. Objective: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. Methods: A review of case reports on SLN published during the years 1970–2004 was performed. Results: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a ‘jentigo’ pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. Conclusions: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level.

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“…43 Since then, several cases have been described. 44,,,,,,,,,,,,,,,,–62 Melanoma in NS usually arises in Caucasian and black patients, on the trunk (64%) or limbs (36%), and has a female to male ratio of 56:44. The mean age of patients is 49 years (median 53 years; range 17–79 years).…”

Section: Discussionmentioning

confidence: 99%