Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient

Oosterhof, Liesbeth; Christensen, Christa Lykke; Sengeløv, Henrik

doi:10.1038/bmt.2009.292

Cited by 55 publications

(52 citation statements)

References 8 publications

(6 reference statements)

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“…HCoV-NL63 was detected in a BAL sample from 1 patient who died of respiratory failure, who also had influenza A and HMPV detected simultaneously. Four cases of lower respiratory tract infections have been described including a fatal HCoV–NL63 infection in an adult HCT patient [72, 73*, 74]. Thus, HCoVs may occasionally cause lower respiratory tract disease after HCT, but the overall progression rate seems to be very low.…”

Section: Newly Discovered Respiratory Virusesmentioning

confidence: 99%

Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients

Renaud¹,

Campbell

2011

Current Opinion in Infectious Diseases

127

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Purpose of review New respiratory viruses have been discovered in recent years and new molecular diagnostic assays have been developed that improve our understanding of respiratory virus infections. This article will review the changing epidemiology of these viruses after hematopoietic stem cell and solid organ transplantation. Recent findings Respiratory viruses are frequently detected in transplant recipients. A number of viruses have been newly discovered or emerged in the last decade, including human metapneumovirus, human bocavirus, new human coronaviruses and rhinoviruses, human polyomaviruses, and a new 2009 pandemic strain of influenza A/H1N1. The potential for these viruses to cause lower respiratory tract infections after transplantation varies, and is greatest for human metapneumovirus and H1N1 influenza, but appears to be limited for the other new viruses. Acute and long term complications in hematopoietic and solid organ transplant recipients are active areas of research. Summary Respiratory viral infections are frequently associated with significant morbidity following transplantation and are therefore of great clinical and epidemiologic interest. As new viruses are discovered, and more sensitive diagnostic methods are developed, defining the full impact of emerging respiratory viruses in transplant recipients must be elucidated by well-designed clinical studies.

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Section: Newly Discovered Respiratory Virusesmentioning

confidence: 99%

Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients

Renaud¹,

Campbell

2011

Current Opinion in Infectious Diseases

127

View full text Add to dashboard Cite

show abstract

“…A number of respiratory viruses can infect hematopoietic cell transplant recipients [28] and emergent respiratory virus infection caused by human metapneumovirus [29], severe acute respiratory syndrome virus [30], and more recently by human coronavirus NL63 [31] has been documented in bone marrow transplant recipients. However, this is the first time that clinical findings, therapeutic measures, and a post-mortem examination from a transplant recipient with fatal outcome caused by the pandemic S-OIV infection is documented.…”

Section: Discussionmentioning

confidence: 99%

Fatal 2009 pandemic influenza A (H1N1) in a bone marrow transplant recipient

Abdo¹,

Alfonso²,

Díaz³

et al. 2010

J Infect Dev Ctries

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Conditions characterized by immunosuppression have been recently reported as risk factors for severe novel swine-origin influenza A (H1N1) virus (S-OIV) infection during the current 2009 pandemic. We report clinical and virological findings, antiviral therapy, and postmortem study of S-OIV in an adult bone marrow transplant recipient. The viral genome was amplified by real time reverse transcriptase polymerase chain reaction (RT-PCR) from a nasopharyngeal swab specimen. The patient developed acute respiratory distress syndrome, septic shock, and eventually succumbed with a severe pulmonary haemorrhage. To the best of our knowledge, the entire clinical/therapy management and pathological examination in a transplant recipient infected with the S-OIV has not been previously documented. The fatal ending in this bone marrow transplant recipient supports recommendations that call for education measures, S-OIV vaccination, early diagnosis and aggressive treatment in the transplant population.

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“…and often led to mild, self-limiting disease [14]. Only few cases with infection of the four HCoVs were associated with pneumonia requiring hospitalization, and even fatal outcomes [15,16]. Furthermore, infection with the four HCoVs might be also involved in digestive dysfunctions [17].…”

Section: Introductionmentioning

confidence: 99%

A Melting Curve-Based Multiplex RT-qPCR Assay for Simultaneous Detection of Four Human Coronaviruses

Wan

Zhang

et al. 2016

IJMS

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Human coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1 are common respiratory viruses associated with acute respiratory infection. They have a global distribution. Rapid and accurate diagnosis of HCoV infection is important for the management and treatment of hospitalized patients with HCoV infection. Here, we developed a melting curve-based multiplex RT-qPCR assay for simultaneous detection of the four HCoVs. In the assay, SYTO 9 was used to replace SYBR Green I as the fluorescent dye, and GC-modified primers were designed to improve the melting temperature (Tm) of the specific amplicon. The four HCoVs were clearly distinguished by characteristic melting peaks in melting curve analysis. The detection sensitivity of the assay was 3 × 102 copies for HCoV-OC43, and 3 × 101 copies for HCoV-NL63, HCoV-229E and HCoV-HKU1 per 30 μL reaction. Clinical evaluation and sequencing confirmation demonstrated that the assay was specific and reliable. The assay represents a sensitive and reliable method for diagnosis of HCoV infection in clinical samples.

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Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient

Cited by 55 publications

References 8 publications

Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients

Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients

Fatal 2009 pandemic influenza A (H1N1) in a bone marrow transplant recipient

A Melting Curve-Based Multiplex RT-qPCR Assay for Simultaneous Detection of Four Human Coronaviruses

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