Fatal Infections With Echovirus Types 6 and 11 in Early Infancy

Fatal Neonatal Echovirus 6 Infection: Autopsy Case Report and Review of the Literature

“…However, massive hepatic and adrenal necrosis has been reported mostly in newborns with echovirus 11 at autopsy (16) and is not a common observation in echovirus 6 infections. To our knowledge, only one case of hepatoadrenal necrosis in an echovirus 6 infection has been reported aside from our case (5).…”

“…Two cases were associated with a maternal history of upper respiratory tract infection, and in both patients, delivery was performed by caesarian sec- tion (5,6). This history of maternal illness and caesarian section delivery is similar to the patient we studied.…”

Neonatal Echovirus Encephalitis with White Matter Necrosis

“…Infection of cells results in cell death and the release of infectious virus. It seems that viral cytotoxicity is more involved in cerebralIesions than vasculitis, occlusion or infarction (5). In conclusion, one ought to proceed with caution in considering that echovirus can cause cerebralIesions in the neonate.…”

Enteroviral hepatitis in children

“…Enteroviruses cause a spectrum of manifestations in neonates, from asymptomatic infection to severe, fulminant, sometimes fatal diseases. Among the series of newborns with enterovirus‐associated clinical illness, fatality rates of 0−42% have been reported 3−13 . Death is often associated with the presence of myocarditis or hepatitis.…”

“…Among the series of newborns with enterovirus-associated clinical illness, fatality rates of 0-42% have been reported. [3][4][5][6][7][8][9][10][11][12][13] Death is often associated with the presence of myocarditis or hepatitis. Enteroviral hepatitis, caused by echoviruses, coxsackie B viruses and coxsackie A viruses, can progress to necrosis and hepatic failure.…”