2011
DOI: 10.1001/jama.2011.574
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Abstract: In this population-based cohort, systolic blood pressure, but not diastolic pressure, changes over time aligned with change in sodium excretion, but this association did not translate into a higher risk of hypertension or CVD complications. Lower sodium excretion was associated with higher CVD mortality.

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Cited by 495 publications
(423 citation statements)
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“…1,2 Focusing on dietary advice for individuals, salt reduction is very difficult to achieve without knowing the daily salt intake of each patient. For the evaluation of salt intake, an estimation based on sodium (Na) content in 24-h pooled urine is reliable and has been used in many clinical trials, [3][4][5][6] but this method is difficult to perform in outpatients in daily medical practice. In contrast, the evaluation of salt intake using the Na concentration in a spot urine sample is very easy to perform.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Focusing on dietary advice for individuals, salt reduction is very difficult to achieve without knowing the daily salt intake of each patient. For the evaluation of salt intake, an estimation based on sodium (Na) content in 24-h pooled urine is reliable and has been used in many clinical trials, [3][4][5][6] but this method is difficult to perform in outpatients in daily medical practice. In contrast, the evaluation of salt intake using the Na concentration in a spot urine sample is very easy to perform.…”
Section: Introductionmentioning
confidence: 99%
“…Most studies showed a net difference in Na intake between 70 and 110 mmol/d (1·680 and 2·640 mg Na/d, respectively). Two studies reported a net difference outside the previously mentioned range (14,19) . One study did not report specific data (15) .…”
Section: Potential Sources Of Heterogeneitymentioning
confidence: 95%
“…9,10 It is likely that these individual variations in salt sensitivity differentially affect cardiovascular and renal risk and may also explain the inconsistent results from population studies investigating the relation between sodium intake and cardiovascular risk. 11 According to Guyton's pressurenatriuresis curve, the kidney regulates long-term BP by altering renal sodium excretion in response to variations in sodium intake. When renal sodium excretion capacity is limited by intrarenal or extrarenal factors, this will result in an increase in BP, which in turn, increases renal sodium excretion at the expense of a higher BP (i.e., salt sensitivity).…”
mentioning
confidence: 99%