Fatal Accidental Hydrogen Sulfide Poisoning: A Domestic Case

Sastre, Caroline; Baillif-Couniou, Valérie; Kintz, Pascal; Cirimele, Vincent; Bartoli, Christophe; Christia-Lotter, Marie-Amandine; Piercecchi-Marti, Marie-Dominique; Léonetti, Georges; Pélissier-Alicot, Anne-Laure

doi:10.1111/1556-4029.12015

Cited by 22 publications

(17 citation statements)

References 20 publications

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“…In sewer networks, the initial driver for studying biological transformation in general, and biofilms in particular, has been the need to control the formation of hydrogen sulphide . Hydrogen sulphide is a gas and is odorous, toxic, and causes degradation of concrete surfaces within the sewer . These are all problems that cause genuine concerns and costs for sewer network operators.…”

Section: Understanding and Solving The Problem Of Hydrogen Sulphidementioning

confidence: 99%

The importance of sewer biofilms

2016

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In spite of being under ground and out of sight, sewers are important parts of the urban infrastructure for transporting used, contaminated water for safe treatment. Within sewers, during the transport of waste water, processes take place, transforming the chemical components of the waste water. These processes are largely carried out by bacteria, a significant part of which live in biofilms. These microbial processes impact the sewers by causing odor and corrosion of the sewer pipes, leading to the need costly repair and control strategies. The biofilms may also impact the environment by contributing to greenhouse gasses in the atmosphere and pollution in natural aquatic environments. However, improved understanding of the function of biofilms and the novel techniques and approaches for manipulating biofilms may provide us with strategies for controlling these problems. Moreover, such advances may allow us to design in-sewer biofilms for beneficial purposes such as in-pipe treatment of waste water, potentially leading to decreased environmental impact. © 2016 The Authors. WIREs Water published by Wiley Periodicals, Inc. How to cite this article:WIREs Water 2016Water , 3:487-494. doi: 10.1002Water /wat2.1144 INTRODUCTION S ewers are extremely important components of urban infrastructure that helps keep the urban environment safe from flooding and prevents the spread of water-borne diseases by safely transporting waste water to the waste water treatment works and through the transport of rain water from urban surfaces.1 Naturally, the focus on sewer design and construction has been on the function of the sewer networks with respect to safe transport of water to fulfill this vital role within urban infrastructure. However, over the years, the understanding of sewer function has been expanded, so that expectations of the urban drainage systems is now also to help minimize the impact of urban activities on the natural environment 2,3 and to prevent odor from waste water in the urban environment. 4 In light of increasing expectations, it is necessary now, more than ever, to design robust sewer networks to fulfil the expected design life of 50-100 years. Existing sewer networks are under increasing strain mainly due to population growth, increasing urbanization, and climate change. The increasing strain on the sewers manifests itself as operational failures leading to flooding events, increased loads on treatment facilities leading to poor quality of water discharge, and leaks linked to enhanced structural deterioration due to concrete corrosion. Early on in the history of the modern sewer networks, it was discovered that the degradation of the materials that the sewers are built from, i.e., mostly concrete, is a consequence of the environment within the sewers. 5 This has led to an increased focus on the processes taking place inside the sewers during the transport of the waste water. 6 It is now generally recognized that the chemical transformations of the waste water and the environmental conditions in the sewers...

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Section: Understanding and Solving The Problem Of Hydrogen Sulphidementioning

confidence: 99%

The importance of sewer biofilms

2016

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“…The primary mechanism underlying H 2 S toxicity is the inhibition of mitochondrial respiratory chain by HS À (a hydrogen sulfide ion). HS À binds to ferric iron (Fe 3+ ) of cytochrome oxidase C. It culminates into sulfmethemoglobinemia, lactic acidosis, and hypoxia (Sastre et al 2013). H 2 S is not completely oxidized by brain, making it most vulnerable for the toxic effects.…”

Section: Neuroinflammation and Other Factorsmentioning

confidence: 99%

Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases

Nagpure

Bian

2015

Handbook of Experimental Pharmacology

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For more than 300 years, the toxicity of hydrogen sulfide (H2S) has been known to mankind. However, this point of view is changing as an increased interest was observed in H2S biology in the last two decades. The scientific community has succeeded to unravel many important physiological and pathological effects of H2S on mammalian body systems. Thus, H2S is now referred to as a third endogenous gaseous mediator along with nitric oxide and carbon monoxide. Acting as a neuromodulator, H2S facilitates long-term potentiation and regulates intracellular calcium levels, which are important processes in learning and memory. Aberrant endogenous production and metabolism of H2S are implicated in pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). Various H2S donors have shown beneficial therapeutic effects in neurodegenerative disease models by targeting hallmark pathological events (e.g., amyloid-β production in AD and neuroinflammation in PD). The results obtained from many in vivo studies clearly show that H2S not only prevents neuronal and synaptic deterioration but also improves deficits in memory, cognition, and learning. The anti-inflammatory, antioxidant, and anti-apoptotic effects of H2S underlie its neuroprotective properties. In this chapter, we will overview the current understanding of H2S in context of neurodegenerative diseases, with special emphasis on its corrective effects on impaired learning, memory, and cognition.

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“…Although measurement of hydrogen sulfide in lung tissue after fatal hydrogen sulfide poisoning has been described [9], there is the possibility of hydrogen sulfide production postmortem by putrefaction in people dying from other causes [10].…”

Section: Introductionmentioning

confidence: 99%

Postmortem Biochemistry and Toxicology

2017

AJFSFM

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Fatal Accidental Hydrogen Sulfide Poisoning: A Domestic Case

Cited by 22 publications

References 20 publications

The importance of sewer biofilms

The importance of sewer biofilms

Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases

Postmortem Biochemistry and Toxicology

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