2016
DOI: 10.18632/aging.100970
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Abstract: Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects of aging and DR. Metabolomic data uncovered a clear distinction between the serum metabolite profile… Show more

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Cited by 40 publications
(31 citation statements)
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References 55 publications
(31 reference statements)
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“…An additional study showed that a Dicer knockout in adipose tissue effectively reversed the slowed rate of aging brought about by dietary restriction in mice (Reis et al, 2016). The detrimental effects to longevity seen when Dicer, a key maturing step in the development of miRNAs, is knocked out indicates miRNAs could play a crucial role in many areas of development.…”
Section: Mirna Synthesis/actionmentioning
confidence: 99%
“…An additional study showed that a Dicer knockout in adipose tissue effectively reversed the slowed rate of aging brought about by dietary restriction in mice (Reis et al, 2016). The detrimental effects to longevity seen when Dicer, a key maturing step in the development of miRNAs, is knocked out indicates miRNAs could play a crucial role in many areas of development.…”
Section: Mirna Synthesis/actionmentioning
confidence: 99%
“…Retrospective studies also demonstrate an association between CR and health span in humans [ 3 ]. The exact mechanism underlying the benefits of CR remains unknown, but it involves changes in nutrient-sensing pathways, metabolic homeostasis, and body composition [ 1 , 4 , 5 , 6 ]. Weight loss is a normal feature of CR, and some groups claim that it is necessary for beneficial effects, including a reduction of chronic inflammation, which is an important trigger of non-communicable diseases [ 7 , 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…More recently, it has become clear that post-transcriptional regulators also play a key role in influencing adipocyte phenotype. Studies with adipose-specific dicer KO mice demonstrate that microRNAs (miRNAs) are essential in regulating adipogenesis, insulin sensitivity and non-shivering thermogenesis 8,9 . Several individual miRNAs have been shown to contribute to these phenotypic effects.…”
Section: Figmentioning
confidence: 99%