volume 8, issue 6, P1201-1222 2016
DOI: 10.18632/aging.100970
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Felipe C. G., Jéssica L. O., Bruna B. Brandão, Beatriz A. Guerra, Ismael D. Silva, Andrea Frontini, Thomas Thomou, Loris Sartini, Saverio Cinti, C. Ronald Kahn, William T. Festuccia, Alicia J. Kowaltowski, Marcelo A. Mori

Abstract: Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specific Dicer knockout mice (AdicerKO) to understand the contributions of adipose tissue Dicer to the metabolic effects of aging and DR. Metabolomic data uncovered a clear distinction between the serum metabolite profile…

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