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Cited by 5 publications
(3 citation statements)
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References 7 publications
(7 reference statements)
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“…Although tyrosine kinase inhibitors are frequently used in the treatment of many types of cancer [28], the therapeutic benefits are not long lasting. Recent studies suggest that fasting conditions enhances the potency of the frequently used tyrosine kinase inhibitors such as erlotinib and lapatinib to inhibit MAPK signaling and cancer cell growth [29]. Our observations that p38 MAPK and JNK phosphorylation were downregulated after fasting in the liver support the notion that more research/clinical studies are required to explore the benefits of fasting in improving the potency of tyrosine kinase inhibitors in cancer treatment.…”
Section: Enhanced Hepatic Inflammatory Response After Fasting and Refeeding A High Cho Diet In Mkp-1-deficient Liversupporting
confidence: 76%
“…Although tyrosine kinase inhibitors are frequently used in the treatment of many types of cancer [28], the therapeutic benefits are not long lasting. Recent studies suggest that fasting conditions enhances the potency of the frequently used tyrosine kinase inhibitors such as erlotinib and lapatinib to inhibit MAPK signaling and cancer cell growth [29]. Our observations that p38 MAPK and JNK phosphorylation were downregulated after fasting in the liver support the notion that more research/clinical studies are required to explore the benefits of fasting in improving the potency of tyrosine kinase inhibitors in cancer treatment.…”
Section: Enhanced Hepatic Inflammatory Response After Fasting and Refeeding A High Cho Diet In Mkp-1-deficient Liversupporting
confidence: 76%
“…However, words of caution are appropriate regarding its application in patients with cancer. For instance, preclinical studies show severe, albeit transient, weight loss in animal models (20–40% of total bodyweight after 24–48 h of fasting [12, 19, 23, 39, 95]. In contrast, the impact of a few days of fasting on bodyweight of humans appears far more modest (~ 1 kg per day, largely water loss) [26], which is probably explained by metabolic differences between humans and mice [95].…”
Section: From Animal Models To the Clinicmentioning
confidence: 99%
“…In both the breast and prostate cancer models, metastatic burden was decreased and overall survival was increased. Multiple in vivo studies in lung, colorectal, melanoma, pancreatic and breast cancer models [77,79,80] have shown that short-term or time-restricted diet protect the normal cells from toxicities due to radiation and chemotherapy. Normal cells are thought to protect themselves against the extreme changes in their microenvironment caused by starvation by adapting, temporarily shutting down growth pathways, decreasing IGF-1, increasing AMPK and using alternative sources of energy such as ketone bodies.…”
Section: Diet Improves Sensitivity To Cancer Treatmentsmentioning
confidence: 99%