Fast setting calcium phosphate–chitosan scaffold: mechanical properties and biocompatibility

Xu, Hockin H.K.; Simon, Carl G.

doi:10.1016/j.biomaterials.2004.04.043

Cited by 255 publications

(220 citation statements)

References 52 publications

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“…Allografts have been used, but they are in limited supply and increase the risk of disease transmission. Calcium phosphates such as tricalcium phosphates and hydroxyapatites have been reported to act as osteoconductive synthetic bone substitutes; however, the clinical applications of these substances are limited by insufficient mechanical properties [3]. Bone-tissue engineering has been studied as an alternative treatment for bone regeneration, and bone marrow stromal cells (MSCs) represent a potential source of multipotent cells for autologous bone-tissue engineering [4][5][6][7].…”

mentioning

confidence: 99%

In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate

Kim

Suh

et al. 2005

Biochemical and Biophysical Research Communications

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mentioning

confidence: 99%

In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate

Kim

Suh

et al. 2005

Biochemical and Biophysical Research Communications

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“…Chitosan is biodegradable and biocompatible and is becoming more prevalent in the drug delivery arena [1,7,17,19,25,40,43]. Chitosan has been used as a material incorporated into implantable scaffolds in several studies [39,[41][42][43]. Further studies demonstrate chitosan is bacteriostatic and enhances wound healing rates [8,19,25,35,38].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Noel

Courtney

Bumgardner

et al. 2008

Clinical Orthopaedics &Amp; Related Research

103

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Local antibiotic delivery is an emerging area of study designed to provide alternative methods of treatment to clinicians for compromised wound sites where avascular zones can prevent the delivery of antibiotics to the infected tissue. Antibiotic-loaded bone cement is the gold standard for drug-eluting local delivery devices but is not ideal because it requires a removal surgery. Chitosan is a biocompatible, biodegradable polymer that has been used in several different drug delivery applications. We evaluated chitosan as a potential localized drug delivery device. We specifically determined if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting S. aureus growth. Elution of amikacin was 24.67 ± 2.35 lg/mL (85.68%) after 1 hour with a final cumulative release of 27.31 ± 2.86 lg/mL (96.23%) after 72 hours. Elution of daptomycin was 10.17 ± 3.83 lg/mL after 1 hour (31.61% release) and 28.72 ± 6.80 lg/mL after 72 hours (88.55%). The data from the elution study suggested effective release of amikacin and daptomycin. The activity studies indicated the eluants inhibited the growth of S. aureus. Incorporating antibiotics in chitosan could provide alternative methods of treating musculoskeletal infections.

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“…This concept also incorporates the problems associated with chemical degradation of materials, given that the physiological environment can be very aggressive, even to materials considered to be extremely chemically inert, leading to reduction of implant efficiency 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Fiber-enriched calcium phosphate cement implanted in the femur of rats: a histological evaluation.

Berthold

2014

Rev. da Fac. de Odontologia, UPF

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Fast setting calcium phosphate–chitosan scaffold: mechanical properties and biocompatibility

Cited by 255 publications

References 52 publications

In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate

In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Fiber-enriched calcium phosphate cement implanted in the femur of rats: a histological evaluation.

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