Fascioliasis--A Large Outbreak

Hardman, Elaine; Jones, R. L.; Davies, Alun H.

doi:10.1136/bmj.3.5721.502

Cited by 59 publications

(17 citation statements)

References 6 publications

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“…24 Most fasciolicide treatments are either toxic, ineffective for parasites in both the mature and immature stages, or contraindicated; and efficacy still needs to be confirmed in human infection. Examples of fasciolicides include chloroquine, 25,26 emetine and dehydroemetine, 27,28 metronidazole, 29 niclofolan, 29,30 bithionol, [31][32][33] and praziquantel. 6,9,28,34-37 Triclabendazole, a fasciolicide used effectively in veterinary medicine, has been proved to be effective and safe in treating human fascioliasis.…”

Section: Resultsmentioning

confidence: 99%

Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).

Massoud

Sisi²,

Salama³

2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. We studied 7 patients who were passing Fasciola eggs in their stools and treated them with myrrh. The drug (a formulation consisting of 8 parts of resin and 3.5 parts of volatile oils, all extracted from myrrh) was given in a dose of 12 mg/kg per day for 6 consecutive days in the morning on an empty stomach. Patients were followed for 3 months. The therapy proved to be effective, with pronounced improvement of the general condition and amelioration of all symptoms and signs. A dramatic drop in the egg count was detected at the end of treatment. Eggs were no longer detectable in the feces 3 weeks after treatment and after a follow-up period of 3 months. High eosinophilic counts, elevated liver enzymes, and Fasciola antibody titers returned to nearly normal. No signs of toxicity or adverse effects were observed. We conclude that the formulation of myrrh is safe, well tolerated, and effective for treating fascioliasis.

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Section: Resultsmentioning

confidence: 99%

Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).

Massoud

Sisi²,

Salama³

2001

The American Journal of Tropical Medicine and Hygiene

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“…Adult fasciolas are able to deposit eggs in inflamed liver parenchyma (Acosta-Ferreira et al, 1979;Goodman et al, 1973;Hardman et al, 1970;Jones et al, 1977). Fasciola eggs were recovered from the aspirate of an hepatic abscess (Perry et al, 1972).…”

Section: Ectopic Mature Flukes and Upper Body Locationsmentioning

confidence: 97%

Neurological and Ocular Fascioliasis in Humans

Mas‐Coma

Agramunt

Valero

2014

Advances in Parasitology

105

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“…Before bithionol, the drug of choice was dehydroemetine or the related compound emetine, which showed a 93% cure rate in one series [34,35]. The major drawback to this drug is its toxicity, including such cardiac side effects as hypotension, prolongation of the QT interval on electrocardiography, and possible arrhythmias.…”

Section: Fasciola Hepaticamentioning

confidence: 99%

Update on hepatobiliary and pulmonary flukes

Hawn

Jong

1999

Curr Infect Dis Rep

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Hepatobiliary and pulmonary trematodes continue to cause significant morbidity and mortality worldwide. This article provides a selected update on the clinical features, diagnosis, immunology, treatment, and control of infections caused by Clonorchis sinensis, Opisthorchis species, Fasciola hepatica, and Paragonimus species. Although recent molecular studies have elucidated novel mechanisms of immune evasion in Paragonimus westermani and F. hepatica, there are no immediate prospects for a vaccine for any of these trematodes. Although treatment of paragonimiasis, clonorchiasis, and opisthorchiasis was simplified with praziquantel in the 1980s, eradication of fascioliasis remains difficult because of the limited availablity of bithionol. Several experimental drugs have been tested as possible alternatives. Despite successful pilot public health programs designed to decrease transmission of these trematodes, their prevalence remains high and underlines the importance of allocating resources to control them.

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Fascioliasis--A Large Outbreak

Cited by 59 publications

References 6 publications

Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).

Preliminary study of therapeutic efficacy of a new fasciolicidal drug derived from Commiphora molmol (myrrh).

Neurological and Ocular Fascioliasis in Humans

Update on hepatobiliary and pulmonary flukes

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