Farmacodermia em um cão após administração de antibióticos do grupo betalactâmico: relato de caso

Drug Reaction Caused by Clavulanate Amoxicillin in Dogs: Report of two CasesDrug Reaction Caused by Clavulanate Amoxicillin in Dogs: Report of two Cases

“…In the animals reported the diagnostic was based on clinical findings and time of lesion evolution after appeared days after the beginning of antibiotic administration, since there was not allergic tests for clavulanate-amoxycillin in clinical practice. The treatment is based on discontinuing the therapy and if necessary replacing the drug with another pharmacological class [1,4,7]. The glucocorticoid use or anti histamine may be indicated depending on the type of clinical manifestations presented.…”

“…Due to fast reestablishment of the animals after discontinuation of the drug, the histopathological exam was not necessary. Obteining an early diagnosis is necessary to avoid severe consequences or even the death of the patient [5,7]. It is important to take into account the history of the animal in order to prevent another prescription of the same drug, which may have more serious consequences.…”

“…In dogs pharmacodermia reports are scarce. In Brazil, cases of pharmacodermia have been reported in dogs after chemotherapy with carboplatin [6], cephalexin prescribed after ovariosalpingohisterectomy procedure [7] and by excessive dose of antibiotic therapy with trimethoprim and sulfamadiazine [8]. The pharmacodermia is characterized by allergic reaction with clinical alterations on the skin, mucous membranes and annexes, due to use of certain medicines [6,9].…”