Far‐Red Aggregation‐Induced Emission Hydrogel‐Reinforced Tissue Clearing for 3D Vasculature Imaging of Whole Lung and Whole Tumor
Xiao‐Ting Gong,
Jiahao Zhuang,
Kok Chan Chong
et al.
Abstract:Understanding the vascular formation and distribution in metastatic lung tumors is a significant challenge due to autofluorescence, antibody/dye diffusion in dense tumor, and fluorophore stability when exposed to solvent‐based clearing agents. Here, an approach is presented that redefines 3D vasculature imaging within metastatic tumor, peritumoral lung tissue, and normal lung. Specifically, a far‐red aggregation‐induced emission nanoparticle with surface amino groups (termed as TSCN nanoparticle, TSCNNP) is de… Show more
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