Far‐Field Superresolution Imaging via Spatial Frequency Modulation

Tang, Mingwei; Liu, Xiaowei; Zhong, Wen; Lin, Feihong; Meng, Chao; Liu, Xu; Ma, Yaoguang; Yang, Qing

doi:10.1002/lpor.201900011

Cited by 18 publications

(8 citation statements)

References 310 publications

(546 reference statements)

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“…The evanescent‐to‐propagating‐conversion (ETPC) efficiency determines the final imaging resolution. [ 608 ] Further improvement of the resolution can be accomplished by enhancing the ETPC efficiency. These ideas motivated the development of the mSIL superlens discussed below, which provides improved ETPC efficiency with enhanced optical super‐resolution and imaging quality.…”

Section: Microsphere Superlens and Metamaterials Solid Immersion Lensmentioning

confidence: 99%

Roadmap on Label‐Free Super‐Resolution Imaging

Astratov,

Sahel,

Eldar

et al. 2023

Laser & Photonics Reviews

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Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state‐of‐the‐art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label‐free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction‐limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super‐resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near‐field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere‐assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

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Section: Microsphere Superlens and Metamaterials Solid Immersion Lensmentioning

confidence: 99%

Roadmap on Label‐Free Super‐Resolution Imaging

Astratov,

Sahel,

Eldar

et al. 2023

Laser & Photonics Reviews

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“…The basic mechanism of the tunable SFS label-free superresolution imaging is shown in figure 1(a). In the SF domain, the finer detail represents higher SF information, only diffraction-limited information can be transmitted to the farfield, leaving a high SF component bound to the object's surface in the form of evanescent waves [27]. A conventional microscope imaging system can be seen as a low pass filter in SF's perspective.…”

Section: Imaging Principlementioning

confidence: 99%

Low loss and omnidirectional Si₃N₄ waveguide for label-free spatial frequency shift super-resolution imaging

Ye¹,

Tang²,

Liu³

et al. 2021

J. Phys. D: Appl. Phys.

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Waveguide-based spatial frequency shift (SFS) super-resolution imaging has attracted growing interest for its high integration, low cost and compatibility with integrated circuit processes. However, a missing band in the spatial frequency (SF) domain severely impedes the final distortionless super-resolution image reconstruction. Here, we present a tunable multi-wavelength SFS method that can light the sample with tunable wavelength illuminations in a sequence using multiple directions of waveguide illumination. The SFS scheme provides broad and complete spectrum information, enabling a reconstructed super-resolution image with high fidelity. An etched three-slot structure and randomly distributed polymer beads on the waveguide surface are imaged and reconstructed with a Gerchberg–Saxton (G-S) SF synthesis algorithm. To the best of our knowledge, this is the first report that shows the waveguide-based label-free super-resolution imaging capability of complex random samples. In the future, the novel SFS imaging waveguide can potentially be integrated with conventional microscopes for chip-based label-free super-resolution imaging.

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“…The near‐field information can be transformed into far‐field information using near‐field illumination techniques for detection, corresponding to the spatial frequency shift (SFS) in the frequency domain. [ 6 , 7 ] Compared with point scanning methods, [ 1 , 2 ] SFS methods can provide high‐speed, high‐resolution, wide‐field imaging. More importantly, in contrast with STED and SMLM methods, which rely on fluorescence excitation with specific characteristics, manipulation in the Fourier domain is universal and compatible with both label‐free and labeled imaging.…”

Section: Introductionmentioning

confidence: 99%

High‐Refractive‐Index Chip with Periodically Fine‐Tuning Gratings for Tunable Virtual‐Wavevector Spatial Frequency Shift Universal Super‐Resolution Imaging

Tang

Han

et al. 2022

Advanced Science

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Continued research in fields such as materials science and biomedicine requires the development of a super‐resolution imaging technique with a large field of view (FOV) and deep subwavelength resolution that is compatible with both fluorescent and nonfluorescent samples. Existing on‐chip super‐resolution methods exclusively focus on either fluorescent or nonfluorescent imaging, and, as such, there is an urgent requirement for a more general technique that is capable of both modes of imaging. In this study, to realize labeled and label‐free super‐resolution imaging on a single scalable photonic chip, a universal super‐resolution imaging method based on the tunable virtual‐wavevector spatial frequency shift (TVSFS) principle is introduced. Using this principle, imaging resolution can be improved more than threefold over the diffraction limit of a linear optical system. Here, diffractive units are fabricated on the chip's surface to provide wavevector‐variable evanescent wave illumination, enabling tunable spatial frequency shifts in the Fourier space. A large FOV and resolutions of λ/4.7 and λ/7.1 were achieved for label‐free and fluorescently labeled samples using a gallium phosphide (GaP) chip. With its large FOV, compatibility with different imaging modes, and monolithic integration, the proposed TVSFS chip may advance fields such as cell engineering, precision industry inspection, and chemical research.

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Far‐Field Superresolution Imaging via Spatial Frequency Modulation

Cited by 18 publications

References 310 publications

Roadmap on Label‐Free Super‐Resolution Imaging

Roadmap on Label‐Free Super‐Resolution Imaging

Low loss and omnidirectional Si₃N₄ waveguide for label-free spatial frequency shift super-resolution imaging

High‐Refractive‐Index Chip with Periodically Fine‐Tuning Gratings for Tunable Virtual‐Wavevector Spatial Frequency Shift Universal Super‐Resolution Imaging

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Far‐Field Superresolution Imaging via Spatial Frequency Modulation

Cited by 18 publications

References 310 publications

Roadmap on Label‐Free Super‐Resolution Imaging

Roadmap on Label‐Free Super‐Resolution Imaging

Low loss and omnidirectional Si3N4 waveguide for label-free spatial frequency shift super-resolution imaging

High‐Refractive‐Index Chip with Periodically Fine‐Tuning Gratings for Tunable Virtual‐Wavevector Spatial Frequency Shift Universal Super‐Resolution Imaging

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Low loss and omnidirectional Si₃N₄ waveguide for label-free spatial frequency shift super-resolution imaging