Family History in Primary Open-Angle Glaucoma

Study profile: the Genetics of Glaucoma Study

“…While the high rate in the media arm could be due to ascertainment bias (people were invited if they had either glaucoma or a family history of glaucoma), among patients with glaucoma, the rate of reported family history was 52% and 59% in the Services Australia and media arms, respectively. These rates are consistent with the previously reported rates of 40%–60% in several studies 14–16. In particular, direct examination of relatives of patients with POAG in a previous study showed that ~60% have affected relatives,16 suggesting that ascertainment bias may not be the main driver of a high rate of family history among patients with glaucoma in GOGS.…”

Study profile: the Genetics of Glaucoma Study

“…While the high rate in the media arm could be due to ascertainment bias (people were invited if they had either glaucoma or a family history of glaucoma), among patients with glaucoma, the rate of reported family history was 52% and 59% in the Services Australia and media arms, respectively. These rates are consistent with the previously reported rates of 40%–60% in several studies 14–16. In particular, direct examination of relatives of patients with POAG in a previous study showed that ~60% have affected relatives,16 suggesting that ascertainment bias may not be the main driver of a high rate of family history among patients with glaucoma in GOGS.…”

Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients

“…The Baltimore Eye Study 23 evaluated first-degree relatives only, which might explain the lower incidence of FHG. Other studies found a frequency of FHG similar to our study, such as 33.2% FHG for all types of glaucoma, 37.9% for POAG, and 35.5% for NTG, 24 or even higher frequencies of FHG in 50% of POAG patients and 43% of OH patients, 25 or 59.5% in POAG patients. 16 The high variability of FHG may partly be explained by the time span between diagnosis of glaucoma and the first interview regarding FHG.…”

Social, health and ocular factors associated with primary open‐angle glaucoma amongst Chinese Singaporeans

“…Older age and family history of glaucoma are well‐established risk factors for POAG, with family history conferring 4–16% increased risk of POAG development . In our study, we also found a significant association of POAG with older age and positive family history (first‐degree relatives) of glaucoma.…”

“…Older age and family history of glaucoma are wellestablished risk factors for POAG, with family history conferring 4-16% increased risk of POAG development. [6][7][8] In our study, we also found a significant association of POAG with older age and positive family history (first-degree relatives) of glaucoma. Gender was not significantly associated with POAG; however, when HTG and NTG were compared, females were more likely to be associated with NTG than with HTG (for both the 19-or 21-mmHg IOP cut-offs for NTG definition).…”

Study profile: the Genetics of Glaucoma Study

“…While the high rate in the media arm could be due to ascertainment bias (people were invited if they had either glaucoma or a family history of glaucoma), among patients with glaucoma, the rate of reported family history was 52% and 59% in the Services Australia and media arms, respectively. These rates are consistent with the previously reported rates of 40%–60% in several studies 14–16. In particular, direct examination of relatives of patients with POAG in a previous study showed that ~60% have affected relatives,16 suggesting that ascertainment bias may not be the main driver of a high rate of family history among patients with glaucoma in GOGS.…”

Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients

“…The Baltimore Eye Study 23 evaluated first-degree relatives only, which might explain the lower incidence of FHG. Other studies found a frequency of FHG similar to our study, such as 33.2% FHG for all types of glaucoma, 37.9% for POAG, and 35.5% for NTG, 24 or even higher frequencies of FHG in 50% of POAG patients and 43% of OH patients, 25 or 59.5% in POAG patients. 16 The high variability of FHG may partly be explained by the time span between diagnosis of glaucoma and the first interview regarding FHG.…”

Social, health and ocular factors associated with primary open‐angle glaucoma amongst Chinese Singaporeans

“…Older age and family history of glaucoma are well‐established risk factors for POAG, with family history conferring 4–16% increased risk of POAG development . In our study, we also found a significant association of POAG with older age and positive family history (first‐degree relatives) of glaucoma.…”

“…Older age and family history of glaucoma are wellestablished risk factors for POAG, with family history conferring 4-16% increased risk of POAG development. [6][7][8] In our study, we also found a significant association of POAG with older age and positive family history (first-degree relatives) of glaucoma. Gender was not significantly associated with POAG; however, when HTG and NTG were compared, females were more likely to be associated with NTG than with HTG (for both the 19-or 21-mmHg IOP cut-offs for NTG definition).…”

Study profile: the Genetics of Glaucoma Study

“…While the high rate in the media arm could be due to ascertainment bias (people were invited if they had either glaucoma or a family history of glaucoma), among patients with glaucoma, the rate of reported family history was 52% and 59% in the Services Australia and media arms, respectively. These rates are consistent with the previously reported rates of 40%–60% in several studies 14–16. In particular, direct examination of relatives of patients with POAG in a previous study showed that ~60% have affected relatives,16 suggesting that ascertainment bias may not be the main driver of a high rate of family history among patients with glaucoma in GOGS.…”

Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients

“…The Baltimore Eye Study 23 evaluated first-degree relatives only, which might explain the lower incidence of FHG. Other studies found a frequency of FHG similar to our study, such as 33.2% FHG for all types of glaucoma, 37.9% for POAG, and 35.5% for NTG, 24 or even higher frequencies of FHG in 50% of POAG patients and 43% of OH patients, 25 or 59.5% in POAG patients. 16 The high variability of FHG may partly be explained by the time span between diagnosis of glaucoma and the first interview regarding FHG.…”

Social, health and ocular factors associated with primary open‐angle glaucoma amongst Chinese Singaporeans

“…Older age and family history of glaucoma are well‐established risk factors for POAG, with family history conferring 4–16% increased risk of POAG development . In our study, we also found a significant association of POAG with older age and positive family history (first‐degree relatives) of glaucoma.…”

“…Older age and family history of glaucoma are wellestablished risk factors for POAG, with family history conferring 4-16% increased risk of POAG development. [6][7][8] In our study, we also found a significant association of POAG with older age and positive family history (first-degree relatives) of glaucoma. Gender was not significantly associated with POAG; however, when HTG and NTG were compared, females were more likely to be associated with NTG than with HTG (for both the 19-or 21-mmHg IOP cut-offs for NTG definition).…”