Family History: An Essential Tool for Cardiovascular Genetic Medicine

Morales, Ana; Cowan, Jason; Dagua, Jimena; Hershberger, Ray E.

doi:10.1111/j.1751-7133.2008.08201.x

Cited by 57 publications

(51 citation statements)

References 40 publications

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“…This group previously has shown the necessity for a careful, prospective, focused 3-to 4-generation history to detect FDC. 17,19 Further, these 2 studies demonstrate that clinical screening of closely related family members adds additional sensitivity to detect FDC. 16,18 Morales et al recommend that these 2 steps (3-to 4-generation family history, consideration of clinical screening for first-degree relatives) be added to all ongoing PPCM study designs.…”

Section: Articles See Pp 2169 and 2176mentioning

confidence: 99%

Birthing the Genetics of Peripartum Cardiomyopathy

Anderson

Horne

2010

Circulation

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Section: Articles See Pp 2169 and 2176mentioning

confidence: 99%

Birthing the Genetics of Peripartum Cardiomyopathy

Anderson

Horne

2010

Circulation

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“…Applications series 1 cardiovascular genetic examples have previously been discussed. 1 In many instances, a detailed family history may aid in recognizing these issues when they are present.…”

Section: In This Emerging Era Of Cardiovascular Genetic Medicine Incmentioning

confidence: 99%

Genetic Testing and Genetic Counseling in Cardiovascular Genetic Medicine: Overview and Preliminary Recommendations

Cowan

Morales

Dagua

et al. 2008

Congestive Heart Failure

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In this emerging era of cardiovascular genetic medicine, increasing responsibility will be placed on cardiovascular practitioners to be aware of the latest clinical genetic testing methods and the knowledge base needed to interpret genetic test results. Some cardiovascular specialists will develop the expertise within the field to order genetic testing and interpret results, while other practitioners will refer patients to centers of excellence in cardiovascular genetic medicine. A previous article in the Cardiovascular Genetic Medicine: Clinical Perspectives and Future Applications series1 highlighted an increasing recognition of the cardiomyopathies (hypertrophic [HCM], dilated [DCM], arrhythmogenic right ventricular dysplasia [ARVD]) and channelopathies (long QT syndrome [LQTS] and others) as genetic diseases, and focused on the importance of a targeted family history as a critical part of patient evaluation. The goal of this article, second in the series, is to provide a general framework for understanding the principles of genetic testing and genetic counseling. We review the growing number of genetic tests currently available to cardiac specialists, the selection of an appropriate test, and the numerous genetic counseling issues raised by the testing process. We also provide our preliminary recommendations for genetic testing in cardiovascular genetic medicine.

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“…[1][2][3][4][5] At least 15-20% of all cancer and coronary heart disease family histories demonstrate hereditary risk patterns. 2,[6][7][8][9][10] Early-onset disease is another important factor in determining familial risk. For many common cancers, early onset ranges from age 45 to 50 years.…”

Section: Introductionmentioning

confidence: 99%