Family-Based Association Studies of Lipid Gene Polymorphisms in Coronary Artery Disease

Allen, Adrian; Belton, Christine; Patterson, Chris; Horan, Paul; McGlinchey, Paul G.; Spence, Mark S.; Evans, Alun; Fogarty, Damian; McKeown, Pascal

doi:10.1016/j.amjcard.2005.02.043

Cited by 17 publications

(13 citation statements)

References 19 publications

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“…Recently Allen et al . found evidence of an association between the HL −480T allele and CAD when the family based pedigree disequilibrium test was used in a well‐defined Irish population [13]. This is in agreement with a Swedish twin study [28], showing that important genetic factors in the pathogenesis of atherosclerosis exert their strongest effect in youth or in early middle‐age.…”

Section: Discussionsupporting

confidence: 76%

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The hepatic lipase gene C‐480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study

Fan

Lehtimäki

Rontu

et al. 2007

Eur J Clin Investigation

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Background The T allele of the hepatic lipase (HL) C-480T polymorphism was previously found to be associated with lower post-heparin plasma HL activity, atherosclerosis and risk of coronary artery disease. We studied the association of HL C-480T polymorphism with the extent of atherosclerosis at vessel-wall level in an autopsy series of middle-aged men. Materials and methodsAn autopsy cohort of 700 Caucasian Finnish men aged 33 -70 years (mean 53 years), which comprised two autopsy series, collected 10 years apart during 1981-82 and 1991-92, were analysed. Areas of coronary wall covered with fatty streaks and fibrotic and complicated lesions were measured using computer-assisted planimetry and related to HL C-480T genotypes (CC, CT, and TT). ResultsThere was a significant age-by-genotype interaction on the mean percentage area of fatty streaks ( P = 0·01). The HL C-480T polymorphism was a significant explanatory factor for fatty streak area in men under 53 years of age with or without age, body mass index, hypertension, diabetes, smoking, alcohol consumption, apolipoprotein E genotype, and series number as covariates. Men carrying the TT genotype had two times larger areas of fatty streaks compared to the CC carriers (8·8% vs. 4·3%, P = 0·009). However, this association disappeared in men over 53 years. The areas of more advanced atherosclerotic lesions did not vary significantly among the genotype groups.Conclusions Our results suggest that the HL C-480T polymorphism affects the formation of early coronary atherosclerotic lesions in men in their early middle age.

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Section: Discussionsupporting

confidence: 76%

“…The findings of these studies have been inconsistent [8–12]. Recently, in a family based study of 1012 patients from 386 families, the −480T allele was found to be associated with CAD [13].…”

Section: Introductionmentioning

confidence: 99%

The hepatic lipase gene C‐480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study

Fan

Lehtimäki

Rontu

et al. 2007

Eur J Clin Investigation

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“…Also there wasn’t any negative interaction of tricuspid valve septal leaflet with the eccentric wings of the device. The authors consider the presence of aneurysm an advantage for perimembranous type defects (8, 22, 23). This reduces the risk of interaction between the device and the aortic valve, but also reduces the risk of AV block since the aneurysm sac does not contain conduction pathways.…”

Section: Discussionmentioning

confidence: 99%

Directly ventricular septal defect closure without using arteriovenous wire loop: Our adult case series using transarterial retrograde approach

Pekel

Ercan

Özpelit³

et al. 2017

Anatol J Cardiol

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Objective:The standard transcatheter ventricular septal defects (VSD) closure procedure is established with arteriovenous (AV) loop and is called as antegrade approach. The directly retrograde transarterial VSD closure without using AV loop might be better option as shortens the procedure time and decreases radiation exposure.Methods:Our series consist of twelve sequential adult cases with congenital VSDs (seven with perimembranous, four with muscular, one with postoperative residuel VSD). The mean age was 26.9 (Range 18–58), the mean height was 168.75 cm (Range 155–185cm), and the mean body mass index was 23.4 (Range 17.3–28.4). Maximum and minimum defect sizes were 10 and 5 mm and the mean defect size was 6.24 mm. The procedure was performed with left heart catheterization and advancing the delivery sheath over the stiff exchange wire then VSD occlusion from left side.Results:The defects were successfully closed with this technique in eleven patients. In sixth patient, the defect could not be cannulated by the delivery sheath, as the tip of the sheath did not reach the defect and VSD was closed with same sheath by standard transvenous approach using AV loop. We didn’t encounter any complication releated to semilunar or atrioventricular valves. Atrioventricular conduction system was not affected by the procedure in any patients. The median procedure and fluoroscopy times were 66 and 16.5 minutes respectively.Conclusion:Transarterial retrograde VSD closure without using AV loop simplifies the procedure, decreases the radiation exposure, and shortens the procedure time. The only limitation in adult patients is delivery sheath length.

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“…All patients received 100 mg aspirin once a day and heparin (100 U/kg) intravenously. The standard technique of transcatheter VSD closure was followed [9, 10]. First, the right femoral artery was punctured, and a 6–8 French sheath was inserted.…”

Section: Methodsmentioning

confidence: 99%

In-Hospital Outcomes and Long-Term Follow-Up after Percutaneous Transcatheter Closure of Postinfarction Ventricular Septal Defects

Zhang

Sun

et al. 2017

BioMed Research International

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Postinfarction ventricular septal defects (VSD) represent a devastating complication of acute myocardial infarction and are associated with high mortality. Percutaneous interventional closure of postinfarction VSD has been proposed as a potential alternative to surgery. The study aimed to evaluate the therapeutic safety and efficacy of percutaneous interventional closure of postinfarction ventricular septal defects (VSD). Each patient was assigned to one of two groups, based on whether they died during hospitalization (death group) or survived (survival group) in this retrospective study. In-hospital and follow-up data were analyzed. Placement of the VSD occluder was successful in 12 procedures (80%). The mean defect size was 14.20 ± 4.89 mm. Compared to the patients who died, those who survived had higher systolic blood pressure, diastolic blood pressure, and left ventricular ejection fraction upon admission, as well as lower pulmonary/systemic flow ratio and shorter time from acute myocardial infarction to procedure. The incidence of cardiac shock and class IV heart failure was lower in the survival group than in the death group, and these factors correlated with in-hospital and 30-day mortality. Percutaneous closure of postinfarction VSD is an effective technique, which can be performed with a high procedural success rate.

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Family-Based Association Studies of Lipid Gene Polymorphisms in Coronary Artery Disease

Cited by 17 publications

References 19 publications

The hepatic lipase gene C‐480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study

The hepatic lipase gene C‐480T polymorphism in the development of early coronary atherosclerosis: the Helsinki Sudden Death Study

Directly ventricular septal defect closure without using arteriovenous wire loop: Our adult case series using transarterial retrograde approach

In-Hospital Outcomes and Long-Term Follow-Up after Percutaneous Transcatheter Closure of Postinfarction Ventricular Septal Defects

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